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Birth after intracytoplasmic sperm injection of ejaculated spermatozoa from a man with mosaic Klinefelter's syndrome.
Asian J Androl. 2005 Jun; 7(2):217-20.AJ

Abstract

AIM

To report a birth after intracytoplasmic sperm injection (ICSI) of ejaculated spermatozoa from a man with mosaic Klinefelter's syndrome detected by fluorescence in situ hybridization (FISH) analysis.

METHODS

A 35-year-old man with a normal appearance consulted our hospital because of sterility over a 5-year period. Chromosome analysis showed low-incidence mosaic Klinefelter's syndrome. Using FISH, 96 % hyperploidy of the lymphocytes was found. We examined the sex chromosome of the ejaculated spermatozoa. Using FISH, we examined 200 ejaculated spermatozoa and no hyperploidy was found.

RESULTS

The 33-year-old female partner of the male patient underwent an uncomplicated controlled ovarian hyperstimulation sequence using a combined recombinant-follicle stimulating hormone (rec-FSH) + human menopausal gonadotrophin (hMG) protocol, following late luteal phase pituitary down regulation. This culminated in the retrieval of seven oocytes, six of which were fertilized with ICSI. One ICSI attempt led to clinical pregnancy with a healthy baby girl.

CONCLUSION

We report a male patient with low-incidence mosaic Klinefelter's syndrome whose ejaculated spermatozoa were identified as being haploid by FISH before ICSI, leading to the successful pregnancy of his wife and the birth of a healthy baby girl.

Authors+Show Affiliations

Department of Urology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Sugitani 2630, Toyama 930-0194, Japan. akashitakuya@mail.goo.ne.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

15897980

Citation

Akashi, Takuya, et al. "Birth After Intracytoplasmic Sperm Injection of Ejaculated Spermatozoa From a Man With Mosaic Klinefelter's Syndrome." Asian Journal of Andrology, vol. 7, no. 2, 2005, pp. 217-20.
Akashi T, Fuse H, Kojima Y, et al. Birth after intracytoplasmic sperm injection of ejaculated spermatozoa from a man with mosaic Klinefelter's syndrome. Asian J Androl. 2005;7(2):217-20.
Akashi, T., Fuse, H., Kojima, Y., Hayashi, M., & Honda, S. (2005). Birth after intracytoplasmic sperm injection of ejaculated spermatozoa from a man with mosaic Klinefelter's syndrome. Asian Journal of Andrology, 7(2), 217-20.
Akashi T, et al. Birth After Intracytoplasmic Sperm Injection of Ejaculated Spermatozoa From a Man With Mosaic Klinefelter's Syndrome. Asian J Androl. 2005;7(2):217-20. PubMed PMID: 15897980.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Birth after intracytoplasmic sperm injection of ejaculated spermatozoa from a man with mosaic Klinefelter's syndrome. AU - Akashi,Takuya, AU - Fuse,Hideki, AU - Kojima,Yasuo, AU - Hayashi,Mikiko, AU - Honda,Sachiko, PY - 2005/5/18/pubmed PY - 2005/12/13/medline PY - 2005/5/18/entrez SP - 217 EP - 20 JF - Asian journal of andrology JO - Asian J. Androl. VL - 7 IS - 2 N2 - AIM: To report a birth after intracytoplasmic sperm injection (ICSI) of ejaculated spermatozoa from a man with mosaic Klinefelter's syndrome detected by fluorescence in situ hybridization (FISH) analysis. METHODS: A 35-year-old man with a normal appearance consulted our hospital because of sterility over a 5-year period. Chromosome analysis showed low-incidence mosaic Klinefelter's syndrome. Using FISH, 96 % hyperploidy of the lymphocytes was found. We examined the sex chromosome of the ejaculated spermatozoa. Using FISH, we examined 200 ejaculated spermatozoa and no hyperploidy was found. RESULTS: The 33-year-old female partner of the male patient underwent an uncomplicated controlled ovarian hyperstimulation sequence using a combined recombinant-follicle stimulating hormone (rec-FSH) + human menopausal gonadotrophin (hMG) protocol, following late luteal phase pituitary down regulation. This culminated in the retrieval of seven oocytes, six of which were fertilized with ICSI. One ICSI attempt led to clinical pregnancy with a healthy baby girl. CONCLUSION: We report a male patient with low-incidence mosaic Klinefelter's syndrome whose ejaculated spermatozoa were identified as being haploid by FISH before ICSI, leading to the successful pregnancy of his wife and the birth of a healthy baby girl. SN - 1008-682X UR - https://www.unboundmedicine.com/medline/citation/15897980/Birth_after_intracytoplasmic_sperm_injection_of_ejaculated_spermatozoa_from_a_man_with_mosaic_Klinefelter's_syndrome_ L2 - http://www.asiaandro.com/Abstract.asp?doi=10.1111/j.1745-7262.2005.00023.x DB - PRIME DP - Unbound Medicine ER -