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Antigenic cross-reactivity between severe acute respiratory syndrome-associated coronavirus and human coronaviruses 229E and OC43.
J Infect Dis. 2005 Jun 15; 191(12):2033-7.JI

Abstract

Cross-reactivity between antibodies to different human coronaviruses (HCoVs) has not been systematically studied. By use of Western blot analysis, indirect immunofluorescence assay (IFA), and enzyme-linked immunosorbent assay (ELISA), antigenic cross-reactivity between severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) and 2 HCoVs (229E and OC43) was demonstrated in immunized animals and human serum. In 5 of 11 and 10 of 11 patients with SARS, paired serum samples showed a > or =4-fold increase in antibody titers against HCoV-229E and HCoV-OC43, respectively, by IFA. Overall, serum samples from convalescent patients who had SARS had a 1-way cross-reactivity with the 2 known HCoVs. Antigens of SARS-CoV and HCoV-OC43 were more cross-reactive than were those of SARS-CoV and HCoV-229E.

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Authors+Show Affiliations

Che XY
Center of Laboratory, Zhujiang Hospital, Southern Medical University, Guangzhou, People's Republic of China. linche@pub.guangzhou.gd.cn
Qiu LW
No affiliation info available
Liao ZY
No affiliation info available
Wang YD
No affiliation info available
Wen K
No affiliation info available
Pan YX
No affiliation info available
Hao W
No affiliation info available
Mei YB
No affiliation info available
Cheng VC
No affiliation info available
Yuen KY
No affiliation info available

MeSH

AdultAnimalsAntibodies, ViralAntigens, ViralCoronavirus 229E, HumanCoronavirus OC43, HumanCross ReactionsFemaleHumansImmunoglobulin GImmunoglobulin MMaleSevere acute respiratory syndrome-related coronavirus

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15897988

Citation

Che, Xiao-Yan, et al. "Antigenic Cross-reactivity Between Severe Acute Respiratory Syndrome-associated Coronavirus and Human Coronaviruses 229E and OC43." The Journal of Infectious Diseases, vol. 191, no. 12, 2005, pp. 2033-7.
Che XY, Qiu LW, Liao ZY, et al. Antigenic cross-reactivity between severe acute respiratory syndrome-associated coronavirus and human coronaviruses 229E and OC43. J Infect Dis. 2005;191(12):2033-7.
Che, X. Y., Qiu, L. W., Liao, Z. Y., Wang, Y. D., Wen, K., Pan, Y. X., Hao, W., Mei, Y. B., Cheng, V. C., & Yuen, K. Y. (2005). Antigenic cross-reactivity between severe acute respiratory syndrome-associated coronavirus and human coronaviruses 229E and OC43. The Journal of Infectious Diseases, 191(12), 2033-7.
Che XY, et al. Antigenic Cross-reactivity Between Severe Acute Respiratory Syndrome-associated Coronavirus and Human Coronaviruses 229E and OC43. J Infect Dis. 2005 Jun 15;191(12):2033-7. PubMed PMID: 15897988.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antigenic cross-reactivity between severe acute respiratory syndrome-associated coronavirus and human coronaviruses 229E and OC43. AU - Che,Xiao-Yan, AU - Qiu,Li-Wen, AU - Liao,Zhi-Yong, AU - Wang,Ya-di, AU - Wen,Kun, AU - Pan,Yu-Xian, AU - Hao,Wei, AU - Mei,Ya-Bo, AU - Cheng,Vincent C C, AU - Yuen,Kwok-Yung, Y1 - 2005/05/06/ PY - 2004/11/06/received PY - 2005/01/19/accepted PY - 2005/5/18/pubmed PY - 2005/7/29/medline PY - 2005/5/18/entrez SP - 2033 EP - 7 JF - The Journal of infectious diseases JO - J Infect Dis VL - 191 IS - 12 N2 - Cross-reactivity between antibodies to different human coronaviruses (HCoVs) has not been systematically studied. By use of Western blot analysis, indirect immunofluorescence assay (IFA), and enzyme-linked immunosorbent assay (ELISA), antigenic cross-reactivity between severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) and 2 HCoVs (229E and OC43) was demonstrated in immunized animals and human serum. In 5 of 11 and 10 of 11 patients with SARS, paired serum samples showed a > or =4-fold increase in antibody titers against HCoV-229E and HCoV-OC43, respectively, by IFA. Overall, serum samples from convalescent patients who had SARS had a 1-way cross-reactivity with the 2 known HCoVs. Antigens of SARS-CoV and HCoV-OC43 were more cross-reactive than were those of SARS-CoV and HCoV-229E. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/15897988/Antigenic_cross_reactivity_between_severe_acute_respiratory_syndrome_associated_coronavirus_and_human_coronaviruses_229E_and_OC43_ DB - PRIME DP - Unbound Medicine ER -
Grapherence [↓110 ↑14]

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