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Helicobacter pylori, pepsinogen, and gastric adenocarcinoma in Hawaii.
J Infect Dis 2005; 191(12):2075-81JI

Abstract

BACKGROUND

The objective was to investigate the association of Helicobacter pylori and serum pepsinogen (PG) levels with gastric adenocarcinoma.

METHODS

Serum obtained from 299 patients at the time of cancer diagnosis and from 336 population-based control subjects was tested for PG I, PG II, and antibodies to H. pylori and to CagA.

RESULTS

Subjects with low PG I levels or low PG I/II ratios were at increased risk for cardia and noncardia gastric cancer, whereas those with H. pylori or CagA seropositivity had an elevated risk for noncardia cancer only. Subjects seropositive for either H. pylori or CagA who had low PG I levels had the highest odds ratio (OR) (9.21 [95% confidence interval {CI}, 4.95-17.13]) for noncardia cancer, compared with subjects with neither factor. Elevated risks were also found among subjects with only 1 factor (OR, 5.40 [95% CI, 2.61-11.20] for low PG I level only; OR, 4.86 [95% CI, 5.90-8.13] for H. pylori or CagA seropositivity only). This pattern persisted when PG I/II ratio replaced PG I level and when CagA seropositivity alone replaced H. pylori immunoglobulin G or CagA seropositivity.

CONCLUSIONS

The results suggest that persons with both H. pylori or CagA seropositivity and a low PG I level or PG I/II ratio are highly susceptible to development of noncardia gastric cancer.

Authors+Show Affiliations

Cancer Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu, Hawaii 96813, USA. abe@crch.hawaii.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15897993

Citation

Nomura, Abraham M Y., et al. "Helicobacter Pylori, Pepsinogen, and Gastric Adenocarcinoma in Hawaii." The Journal of Infectious Diseases, vol. 191, no. 12, 2005, pp. 2075-81.
Nomura AM, Kolonel LN, Miki K, et al. Helicobacter pylori, pepsinogen, and gastric adenocarcinoma in Hawaii. J Infect Dis. 2005;191(12):2075-81.
Nomura, A. M., Kolonel, L. N., Miki, K., Stemmermann, G. N., Wilkens, L. R., Goodman, M. T., ... Blaser, M. J. (2005). Helicobacter pylori, pepsinogen, and gastric adenocarcinoma in Hawaii. The Journal of Infectious Diseases, 191(12), pp. 2075-81.
Nomura AM, et al. Helicobacter Pylori, Pepsinogen, and Gastric Adenocarcinoma in Hawaii. J Infect Dis. 2005 Jun 15;191(12):2075-81. PubMed PMID: 15897993.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Helicobacter pylori, pepsinogen, and gastric adenocarcinoma in Hawaii. AU - Nomura,Abraham M Y, AU - Kolonel,Laurence N, AU - Miki,Kazumasa, AU - Stemmermann,Grant N, AU - Wilkens,Lynne R, AU - Goodman,Marc T, AU - Perez-Perez,Guillermo I, AU - Blaser,Martin J, Y1 - 2005/05/11/ PY - 2004/10/27/received PY - 2005/01/21/accepted PY - 2005/5/18/pubmed PY - 2005/7/29/medline PY - 2005/5/18/entrez SP - 2075 EP - 81 JF - The Journal of infectious diseases JO - J. Infect. Dis. VL - 191 IS - 12 N2 - BACKGROUND: The objective was to investigate the association of Helicobacter pylori and serum pepsinogen (PG) levels with gastric adenocarcinoma. METHODS: Serum obtained from 299 patients at the time of cancer diagnosis and from 336 population-based control subjects was tested for PG I, PG II, and antibodies to H. pylori and to CagA. RESULTS: Subjects with low PG I levels or low PG I/II ratios were at increased risk for cardia and noncardia gastric cancer, whereas those with H. pylori or CagA seropositivity had an elevated risk for noncardia cancer only. Subjects seropositive for either H. pylori or CagA who had low PG I levels had the highest odds ratio (OR) (9.21 [95% confidence interval {CI}, 4.95-17.13]) for noncardia cancer, compared with subjects with neither factor. Elevated risks were also found among subjects with only 1 factor (OR, 5.40 [95% CI, 2.61-11.20] for low PG I level only; OR, 4.86 [95% CI, 5.90-8.13] for H. pylori or CagA seropositivity only). This pattern persisted when PG I/II ratio replaced PG I level and when CagA seropositivity alone replaced H. pylori immunoglobulin G or CagA seropositivity. CONCLUSIONS: The results suggest that persons with both H. pylori or CagA seropositivity and a low PG I level or PG I/II ratio are highly susceptible to development of noncardia gastric cancer. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/15897993/Helicobacter_pylori_pepsinogen_and_gastric_adenocarcinoma_in_Hawaii_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/430353 DB - PRIME DP - Unbound Medicine ER -