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[Expression of bcl-2 and bax protein in uterine leiomyosarcomas and leiomyomas].
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2005 Apr; 30(2):183-6.ZN

Abstract

OBJECTIVE

To determine the expression and significance of the apoptosis regulatory protein bcl-2 and bax in uterine leiomyosarcomas and uterine leiomyomas.

METHODS

The expression of bcl-2 and bax were examined by immunohistochemical ABC staining with specific antibodies in 34 cases of uterine leiomyosarcomas (18 cases in stage I , 1 in stage II , 8 in stage III, and 7 in stage IV), 34 uterine leiomyomas and 34 normal myometrium samples.

RESULTS

Bcl-2 expression was higher in uterine leiomyomas than that in normal myometrium and in uterine leiomyosarcoma (P < 0.01); bcl-2 expression in uterine leiomyosarcoma was higher than that in normal myometrium (P < 0.05). Bax expression in normal myometrium was higher than that in leiomyomas and in uterine leiomyosarcoma (P < 0.01). There was no obvious difference in bax expression between leiomyomas and leiomyosarcoma (P > 0.05). Both the expressions of bcl-2 and bax proteins in stage I - II were higher than those of in stage III - IV (P < 0.01). The bcl-2 positive leiomyosarcoma has a favorable clinical outcome than that of bcl-2 negative.

CONCLUSION

The imbalance between the expression of bcl-2 and bax may play a certain role in the genesis of the uterine leiomyomas and leiomyosarcomas. Bcl-2 and bax may be involved in the early stage of the tumor genesis of uterine leiomyosarcoma. Bcl-2 might correlate with the prognosis of the uterine leiomyosarcoma.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Xiangya Hospital, Central South University, Changsha 410008, China. zhangz199@yahoo.comNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

15898430

Citation

Zhang, Zhi-ling, et al. "[Expression of Bcl-2 and Bax Protein in Uterine Leiomyosarcomas and Leiomyomas]." Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences, vol. 30, no. 2, 2005, pp. 183-6.
Zhang ZL, Zhang Y, Zhou JH. [Expression of bcl-2 and bax protein in uterine leiomyosarcomas and leiomyomas]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2005;30(2):183-6.
Zhang, Z. L., Zhang, Y., & Zhou, J. H. (2005). [Expression of bcl-2 and bax protein in uterine leiomyosarcomas and leiomyomas]. Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences, 30(2), 183-6.
Zhang ZL, Zhang Y, Zhou JH. [Expression of Bcl-2 and Bax Protein in Uterine Leiomyosarcomas and Leiomyomas]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2005;30(2):183-6. PubMed PMID: 15898430.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Expression of bcl-2 and bax protein in uterine leiomyosarcomas and leiomyomas]. AU - Zhang,Zhi-ling, AU - Zhang,Yi, AU - Zhou,Jian-hua, PY - 2005/5/19/pubmed PY - 2006/8/11/medline PY - 2005/5/19/entrez SP - 183 EP - 6 JF - Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences JO - Zhong Nan Da Xue Xue Bao Yi Xue Ban VL - 30 IS - 2 N2 - OBJECTIVE: To determine the expression and significance of the apoptosis regulatory protein bcl-2 and bax in uterine leiomyosarcomas and uterine leiomyomas. METHODS: The expression of bcl-2 and bax were examined by immunohistochemical ABC staining with specific antibodies in 34 cases of uterine leiomyosarcomas (18 cases in stage I , 1 in stage II , 8 in stage III, and 7 in stage IV), 34 uterine leiomyomas and 34 normal myometrium samples. RESULTS: Bcl-2 expression was higher in uterine leiomyomas than that in normal myometrium and in uterine leiomyosarcoma (P < 0.01); bcl-2 expression in uterine leiomyosarcoma was higher than that in normal myometrium (P < 0.05). Bax expression in normal myometrium was higher than that in leiomyomas and in uterine leiomyosarcoma (P < 0.01). There was no obvious difference in bax expression between leiomyomas and leiomyosarcoma (P > 0.05). Both the expressions of bcl-2 and bax proteins in stage I - II were higher than those of in stage III - IV (P < 0.01). The bcl-2 positive leiomyosarcoma has a favorable clinical outcome than that of bcl-2 negative. CONCLUSION: The imbalance between the expression of bcl-2 and bax may play a certain role in the genesis of the uterine leiomyomas and leiomyosarcomas. Bcl-2 and bax may be involved in the early stage of the tumor genesis of uterine leiomyosarcoma. Bcl-2 might correlate with the prognosis of the uterine leiomyosarcoma. SN - 1672-7347 UR - https://www.unboundmedicine.com/medline/citation/15898430/[Expression_of_bcl_2_and_bax_protein_in_uterine_leiomyosarcomas_and_leiomyomas]_ L2 - http://xbyxb.csu.edu.cn/xbwk/fileup/PDF/200504183.pdf DB - PRIME DP - Unbound Medicine ER -