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Low socioeconomic status as a risk factor for asthma, rhinitis and sensitization at 4 years in a birth cohort.
Clin Exp Allergy. 2005 May; 35(5):612-8.CE

Abstract

BACKGROUND

The relation between socioeconomic status and allergic diseases in childhood is controversial. Some studies have proposed childhood asthma to be more common in families with low socioeconomic status, while sensitization to airborne allergens seems to be more frequent in individuals with higher socioeconomic status in childhood.

OBJECTIVE

To assess the relation between socioeconomic status and asthma, rhinitis and sensitization in an unselected prospective birth cohort.

METHODS

Four thousand and eighty-nine families with children born 1994-1996 in predefined areas of Stockholm answered questionnaires on environmental factors, socioeconomic status (parental occupation), and symptoms of allergic disease at birth, 1, 2 and 4 years of age. Blood samples taken at 4 years from 2614 children were analysed for specific IgE to common airborne and food allergens. Odds ratios (OR) and 95% confidence intervals (CI) for various outcomes in relation to socioeconomic status were estimated with a multiple logistic regression model, adjusting for potential confounders such as heredity for allergic diseases, maternal smoking, short duration of breastfeeding and house construction.

RESULTS

There was a decreasing risk of asthma and rhinitis with increasing socioeconomic status. The OR for asthma was 0.33 (95% CI 0.17-0.66) and for rhinitis 0.50 (0.32-0.79) comparing the highest and the lowest socioeconomic groups, with a tendency to stronger effects in those with heredity for allergic disease. The risk of sensitization to food allergens also decreased with increasing socioeconomic status; OR 0.65 (0.41-1.02) in the highest socioeconomic group (Ptrend=0.03), which was not clearly seen for airborne allergens.

CONCLUSION

Asthma, rhinitis and sensitization is more common in lower than in higher socioeconomic groups after adjustment for traditional risk factors. This may be related to additional uncontrolled differences in life style and environmental exposures between the groups, and calls for further studies.

Authors+Show Affiliations

Department of Occupational and Environmental Health, Karolinska Hospital, Stockholm, Sweden. catarina.almqvist@kbh.ki.seNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15898983

Citation

Almqvist, C, et al. "Low Socioeconomic Status as a Risk Factor for Asthma, Rhinitis and Sensitization at 4 Years in a Birth Cohort." Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, vol. 35, no. 5, 2005, pp. 612-8.
Almqvist C, Pershagen G, Wickman M. Low socioeconomic status as a risk factor for asthma, rhinitis and sensitization at 4 years in a birth cohort. Clin Exp Allergy. 2005;35(5):612-8.
Almqvist, C., Pershagen, G., & Wickman, M. (2005). Low socioeconomic status as a risk factor for asthma, rhinitis and sensitization at 4 years in a birth cohort. Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, 35(5), 612-8.
Almqvist C, Pershagen G, Wickman M. Low Socioeconomic Status as a Risk Factor for Asthma, Rhinitis and Sensitization at 4 Years in a Birth Cohort. Clin Exp Allergy. 2005;35(5):612-8. PubMed PMID: 15898983.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low socioeconomic status as a risk factor for asthma, rhinitis and sensitization at 4 years in a birth cohort. AU - Almqvist,C, AU - Pershagen,G, AU - Wickman,M, PY - 2005/5/19/pubmed PY - 2005/9/15/medline PY - 2005/5/19/entrez SP - 612 EP - 8 JF - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology JO - Clin Exp Allergy VL - 35 IS - 5 N2 - BACKGROUND: The relation between socioeconomic status and allergic diseases in childhood is controversial. Some studies have proposed childhood asthma to be more common in families with low socioeconomic status, while sensitization to airborne allergens seems to be more frequent in individuals with higher socioeconomic status in childhood. OBJECTIVE: To assess the relation between socioeconomic status and asthma, rhinitis and sensitization in an unselected prospective birth cohort. METHODS: Four thousand and eighty-nine families with children born 1994-1996 in predefined areas of Stockholm answered questionnaires on environmental factors, socioeconomic status (parental occupation), and symptoms of allergic disease at birth, 1, 2 and 4 years of age. Blood samples taken at 4 years from 2614 children were analysed for specific IgE to common airborne and food allergens. Odds ratios (OR) and 95% confidence intervals (CI) for various outcomes in relation to socioeconomic status were estimated with a multiple logistic regression model, adjusting for potential confounders such as heredity for allergic diseases, maternal smoking, short duration of breastfeeding and house construction. RESULTS: There was a decreasing risk of asthma and rhinitis with increasing socioeconomic status. The OR for asthma was 0.33 (95% CI 0.17-0.66) and for rhinitis 0.50 (0.32-0.79) comparing the highest and the lowest socioeconomic groups, with a tendency to stronger effects in those with heredity for allergic disease. The risk of sensitization to food allergens also decreased with increasing socioeconomic status; OR 0.65 (0.41-1.02) in the highest socioeconomic group (Ptrend=0.03), which was not clearly seen for airborne allergens. CONCLUSION: Asthma, rhinitis and sensitization is more common in lower than in higher socioeconomic groups after adjustment for traditional risk factors. This may be related to additional uncontrolled differences in life style and environmental exposures between the groups, and calls for further studies. SN - 0954-7894 UR - https://www.unboundmedicine.com/medline/citation/15898983/Low_socioeconomic_status_as_a_risk_factor_for_asthma_rhinitis_and_sensitization_at_4_years_in_a_birth_cohort_ L2 - https://doi.org/10.1111/j.1365-2222.2005.02243.x DB - PRIME DP - Unbound Medicine ER -