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Evaluation of the serodia Treponema pallidum particle agglutination, the Murex Syphilis ICE and the Enzywell TP tests for serodiagnosis of syphilis.
Int J STD AIDS. 2005 Apr; 16(4):294-8.IJ

Abstract

We evaluated the Treponema pallidum haemagglutination assay (TPHA), a treponemal test, with three other treponemal tests, the Serodia T. pallidum particle agglutination assay, the Murex Syphilis ICE IgG + IgM enzyme immunoassay (EIA) and the Enzywell TP IgG + M EIA (a new rapid EIA) for use in conjunction with the rapid plasma reagin test (RPR), a non-treponemal test, for serodiagnosis of syphilis. In all, 124 serum samples were found reactive with RPR and/or TPHA after testing by the routine laboratory protocol. Twenty-three (18.5%) of them were positive only by RPR test and were evaluated as biologically false-positive, 16 were positive only by the TPHA and 84 by both the RPR and TPHA tests; one sample was non-specific (heterophile reaction) in the TPHA. Agreements of the TPHA with the Serodia TPPA, the Murex Syphilis ICE and the Enzywell TP tests were 96.7%, 100% and 99.1%, respectively. We conclude that each one of the tests, the Serodia TPPA, the Murex Syphilis ICE and the Enzywell TP, is an appropriate substitute for screening for serodiagnosis of syphilis.

Authors+Show Affiliations

Department of Microbiology and Clinical Microbiology, Istanbul Medical Faculty, University of Istanbul, 34390 Capa, Istanbul, Turkey. gulserena2001@yahoo.co.ukNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15899082

Citation

Aktas, G, et al. "Evaluation of the Serodia Treponema Pallidum Particle Agglutination, the Murex Syphilis ICE and the Enzywell TP Tests for Serodiagnosis of Syphilis." International Journal of STD & AIDS, vol. 16, no. 4, 2005, pp. 294-8.
Aktas G, Young H, Moyes A, et al. Evaluation of the serodia Treponema pallidum particle agglutination, the Murex Syphilis ICE and the Enzywell TP tests for serodiagnosis of syphilis. Int J STD AIDS. 2005;16(4):294-8.
Aktas, G., Young, H., Moyes, A., & Badur, S. (2005). Evaluation of the serodia Treponema pallidum particle agglutination, the Murex Syphilis ICE and the Enzywell TP tests for serodiagnosis of syphilis. International Journal of STD & AIDS, 16(4), 294-8.
Aktas G, et al. Evaluation of the Serodia Treponema Pallidum Particle Agglutination, the Murex Syphilis ICE and the Enzywell TP Tests for Serodiagnosis of Syphilis. Int J STD AIDS. 2005;16(4):294-8. PubMed PMID: 15899082.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of the serodia Treponema pallidum particle agglutination, the Murex Syphilis ICE and the Enzywell TP tests for serodiagnosis of syphilis. AU - Aktas,G, AU - Young,H, AU - Moyes,A, AU - Badur,S, PY - 2005/5/19/pubmed PY - 2005/7/15/medline PY - 2005/5/19/entrez SP - 294 EP - 8 JF - International journal of STD & AIDS JO - Int J STD AIDS VL - 16 IS - 4 N2 - We evaluated the Treponema pallidum haemagglutination assay (TPHA), a treponemal test, with three other treponemal tests, the Serodia T. pallidum particle agglutination assay, the Murex Syphilis ICE IgG + IgM enzyme immunoassay (EIA) and the Enzywell TP IgG + M EIA (a new rapid EIA) for use in conjunction with the rapid plasma reagin test (RPR), a non-treponemal test, for serodiagnosis of syphilis. In all, 124 serum samples were found reactive with RPR and/or TPHA after testing by the routine laboratory protocol. Twenty-three (18.5%) of them were positive only by RPR test and were evaluated as biologically false-positive, 16 were positive only by the TPHA and 84 by both the RPR and TPHA tests; one sample was non-specific (heterophile reaction) in the TPHA. Agreements of the TPHA with the Serodia TPPA, the Murex Syphilis ICE and the Enzywell TP tests were 96.7%, 100% and 99.1%, respectively. We conclude that each one of the tests, the Serodia TPPA, the Murex Syphilis ICE and the Enzywell TP, is an appropriate substitute for screening for serodiagnosis of syphilis. SN - 0956-4624 UR - https://www.unboundmedicine.com/medline/citation/15899082/Evaluation_of_the_serodia_Treponema_pallidum_particle_agglutination_the_Murex_Syphilis_ICE_and_the_Enzywell_TP_tests_for_serodiagnosis_of_syphilis_ L2 - http://journals.sagepub.com/doi/full/10.1258/0956462053654195?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -