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Comparison of posterior capsule opacification rates between hydrophilic and hydrophobic single-piece acrylic intraocular lenses.
J Cataract Refract Surg. 2005 Apr; 31(4):718-24.JC

Abstract

PURPOSE

To determine the effect of intraocular lens (IOL) material on the development of posterior capsule opacification (PCO) at 1 year.

SETTING

Department of Ophthalmology, St. Thomas' Hospital, London, United Kingdom.

METHODS

One hundred six eyes of 53 patients with bilateral cataract and no other ocular comorbidity were prospectively randomized to receive a hydrophobic acrylic or hydrophilic acrylic single-piece IOL in the first eye to have surgery. The alternate IOL was implanted in the fellow eye 4 to 6 weeks later. All surgery was performed by a single surgeon. Postoperative follow-up was 1 day, 1 and 6 months, and 1 year. At each visit, the best corrected high- and low-contrast visual acuities were assessed and a high-intensity digital retroillumination photograph was taken. Posterior capsule opacification was assessed from the digital images by a single operator using a dedicated software program and calculated as the percentage area of opacified capsule.

RESULTS

One year postoperatively, the median percentage area of PCO was 50.3% in the hydrophilic IOL group and 4.9% in the hydrophobic IOL group (P<.001). The difference in PCO was not accounted for by loss of contact between the capsulorhexis and IOL surface. Further analysis showed that lens epithelial cells tended to invade the posterior capsule at the haptic-optic junction. This was more marked in the hydrophilic IOL group.

CONCLUSIONS

The rate of PCO was significantly higher with the hydrophilic IOL. However, the results cannot be attributed to the IOL material alone as they show the importance of both IOL material and design.

Authors+Show Affiliations

Heatley CJ
Department of Ophthalmology, St. Thomas' Hospital, London, United Kingdom.
Spalton DJ
No affiliation info available
Kumar A
No affiliation info available
Jose R
No affiliation info available
Boyce J
No affiliation info available
Bender LE
No affiliation info available

MeSH

Acrylic ResinsBiocompatible MaterialsCataractHumansHydrophobic and Hydrophilic InteractionsLens Capsule, CrystallineLens Implantation, IntraocularLenses, IntraocularPhacoemulsificationPostoperative ComplicationsProspective StudiesProsthesis DesignVisual Acuity

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15899448

Clinical Trial Links

Posterior Capsule Opacification (PCO) With Single Piece Hydrophobic Versus Hydrophillic Intraocular Lens (IOL)

Citation

Heatley, Catherine J., et al. "Comparison of Posterior Capsule Opacification Rates Between Hydrophilic and Hydrophobic Single-piece Acrylic Intraocular Lenses." Journal of Cataract and Refractive Surgery, vol. 31, no. 4, 2005, pp. 718-24.
Heatley CJ, Spalton DJ, Kumar A, et al. Comparison of posterior capsule opacification rates between hydrophilic and hydrophobic single-piece acrylic intraocular lenses. J Cataract Refract Surg. 2005;31(4):718-24.
Heatley, C. J., Spalton, D. J., Kumar, A., Jose, R., Boyce, J., & Bender, L. E. (2005). Comparison of posterior capsule opacification rates between hydrophilic and hydrophobic single-piece acrylic intraocular lenses. Journal of Cataract and Refractive Surgery, 31(4), 718-24.
Heatley CJ, et al. Comparison of Posterior Capsule Opacification Rates Between Hydrophilic and Hydrophobic Single-piece Acrylic Intraocular Lenses. J Cataract Refract Surg. 2005;31(4):718-24. PubMed PMID: 15899448.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of posterior capsule opacification rates between hydrophilic and hydrophobic single-piece acrylic intraocular lenses. AU - Heatley,Catherine J, AU - Spalton,David J, AU - Kumar,Anupma, AU - Jose,Romina, AU - Boyce,James, AU - Bender,Lloyd E, PY - 2004/08/26/accepted PY - 2005/5/19/pubmed PY - 2005/6/17/medline PY - 2005/5/19/entrez SP - 718 EP - 24 JF - Journal of cataract and refractive surgery JO - J Cataract Refract Surg VL - 31 IS - 4 N2 - PURPOSE: To determine the effect of intraocular lens (IOL) material on the development of posterior capsule opacification (PCO) at 1 year. SETTING: Department of Ophthalmology, St. Thomas' Hospital, London, United Kingdom. METHODS: One hundred six eyes of 53 patients with bilateral cataract and no other ocular comorbidity were prospectively randomized to receive a hydrophobic acrylic or hydrophilic acrylic single-piece IOL in the first eye to have surgery. The alternate IOL was implanted in the fellow eye 4 to 6 weeks later. All surgery was performed by a single surgeon. Postoperative follow-up was 1 day, 1 and 6 months, and 1 year. At each visit, the best corrected high- and low-contrast visual acuities were assessed and a high-intensity digital retroillumination photograph was taken. Posterior capsule opacification was assessed from the digital images by a single operator using a dedicated software program and calculated as the percentage area of opacified capsule. RESULTS: One year postoperatively, the median percentage area of PCO was 50.3% in the hydrophilic IOL group and 4.9% in the hydrophobic IOL group (P<.001). The difference in PCO was not accounted for by loss of contact between the capsulorhexis and IOL surface. Further analysis showed that lens epithelial cells tended to invade the posterior capsule at the haptic-optic junction. This was more marked in the hydrophilic IOL group. CONCLUSIONS: The rate of PCO was significantly higher with the hydrophilic IOL. However, the results cannot be attributed to the IOL material alone as they show the importance of both IOL material and design. SN - 0886-3350 UR - https://www.unboundmedicine.com/medline/citation/15899448/Comparison_of_posterior_capsule_opacification_rates_between_hydrophilic_and_hydrophobic_single_piece_acrylic_intraocular_lenses_ DB - PRIME DP - Unbound Medicine ER -