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Antidiabetic effect of Scoparia dulcis: effect on lipid peroxidation in streptozotocin diabetes.
Gen Physiol Biophys. 2005 Mar; 24(1):13-26.GP

Abstract

Oxidative damage has been suggested to be a contributory factor in the development and complications of diabetes. The antioxidant effect of an aqueous extract of Scoparia dulcis, an indigenous plant used in Ayurvedic medicine in India was studied in rats with streptozotocin-induced diabetes. Oral administration of Scoparia dulcis plant extract (SPEt) (200 mg/kg body weight) for 3 weeks resulted in a significant reduction in blood glucose and an increase in plasma insulin. The aqueous extract also resulted in decreased free radical formation in tissues (liver and kidney) studied. The decrease in thiobarbituric acid reactive substances (TBARS) and hydroperoxides (HPX) and increase in the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH) and glutathione-S-transferase (GST) clearly show the antioxidant properties of SPEt in addition to its antidiabetic effect. The effect of SPEt at 200 mg/kg body weight was better than glibenclamide, a reference drug.

Authors+Show Affiliations

Department of Biochemistry, Faculty of Science, Annamalai University, Annamalai Nagar 608 002, Tamil Nadu, India. paribala@sancharnet.inNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15900084

Citation

Pari, L, and M Latha. "Antidiabetic Effect of Scoparia Dulcis: Effect On Lipid Peroxidation in Streptozotocin Diabetes." General Physiology and Biophysics, vol. 24, no. 1, 2005, pp. 13-26.
Pari L, Latha M. Antidiabetic effect of Scoparia dulcis: effect on lipid peroxidation in streptozotocin diabetes. Gen Physiol Biophys. 2005;24(1):13-26.
Pari, L., & Latha, M. (2005). Antidiabetic effect of Scoparia dulcis: effect on lipid peroxidation in streptozotocin diabetes. General Physiology and Biophysics, 24(1), 13-26.
Pari L, Latha M. Antidiabetic Effect of Scoparia Dulcis: Effect On Lipid Peroxidation in Streptozotocin Diabetes. Gen Physiol Biophys. 2005;24(1):13-26. PubMed PMID: 15900084.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antidiabetic effect of Scoparia dulcis: effect on lipid peroxidation in streptozotocin diabetes. AU - Pari,L, AU - Latha,M, PY - 2005/5/19/pubmed PY - 2005/8/12/medline PY - 2005/5/19/entrez SP - 13 EP - 26 JF - General physiology and biophysics JO - Gen Physiol Biophys VL - 24 IS - 1 N2 - Oxidative damage has been suggested to be a contributory factor in the development and complications of diabetes. The antioxidant effect of an aqueous extract of Scoparia dulcis, an indigenous plant used in Ayurvedic medicine in India was studied in rats with streptozotocin-induced diabetes. Oral administration of Scoparia dulcis plant extract (SPEt) (200 mg/kg body weight) for 3 weeks resulted in a significant reduction in blood glucose and an increase in plasma insulin. The aqueous extract also resulted in decreased free radical formation in tissues (liver and kidney) studied. The decrease in thiobarbituric acid reactive substances (TBARS) and hydroperoxides (HPX) and increase in the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH) and glutathione-S-transferase (GST) clearly show the antioxidant properties of SPEt in addition to its antidiabetic effect. The effect of SPEt at 200 mg/kg body weight was better than glibenclamide, a reference drug. SN - 0231-5882 UR - https://www.unboundmedicine.com/medline/citation/15900084/Antidiabetic_effect_of_Scoparia_dulcis:_effect_on_lipid_peroxidation_in_streptozotocin_diabetes_ L2 - http://www.gpb.sav.sk/2005_01_13.pdf DB - PRIME DP - Unbound Medicine ER -