Tags

Type your tag names separated by a space and hit enter

Direct comparison of dietary portfolio vs statin on C-reactive protein.

Abstract

BACKGROUND

3-Hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) markedly reduce serum cholesterol and have anti-inflammatory effects. The effect of cholesterol-lowering diets on inflammatory biomarkers is less well known.

OBJECTIVE

To compare the efficacy of a dietary combination (portfolio) of cholesterol-lowering foods vs a statin in reducing C-reactive protein (CRP) as a biomarker of inflammation linked to increased cardiovascular disease risk.

METHODS

In all, 34 hyperlipidemic subjects completed three 1-month treatments as outpatients in random order: a very low-saturated fat diet (control); the same diet with 20 mg lovastatin (statin); and a diet high in plant sterols (1.0 g/1000 kcal), soy protein (21.4 g/1000 kcal), viscous fibers (9.8 g/1000 kcal), and almonds (14 g/1000 kcal) (portfolio). Fasting blood samples were obtained at weeks 0, 2, and 4.

RESULTS

Using the complete data, no treatment reduced serum CRP. However, when subjects with CRP levels above the 75th percentile for previously reported studies (> 3.5 mg/l) were excluded, CRP was reduced similarly on both statin, -16.3 +/- 6.7% (n = 23, P = 0.013) and dietary portfolio, -23.8 +/- 6.9% (n = 25, P = 0.001) but not the control, 15.3 +/- 13.6% (n = 28, P = 0.907). The percentage CRP change from baseline on the portfolio treatment (n = 25) was greater than the control (n = 28, P = 0.004) but similar to statin treatment (n = 23, P = 0.349). Both statin and portfolio treatments were similar in reducing CRP and numerically more effective than control but only the change in portfolio was significant after the Bonferroni adjustment.

CONCLUSIONS

A combination of cholesterol-lowering foods reduced C-reactive protein to a similar extent as the starting dose of a first-generation statin.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Clinical Nutrition and Risk Factor Modification Center, St Michael's Hospital, Toronto, Ontario, Canada.

    , , , , , , , , , , , ,

    Source

    MeSH

    Adult
    Aged
    Biomarkers
    C-Reactive Protein
    Cardiovascular Diseases
    Cholesterol
    Diet, Fat-Restricted
    Female
    Humans
    Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Hyperlipidemias
    Inflammation
    Male
    Middle Aged
    Risk Factors

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    15900306

    Citation

    Jenkins, D J A., et al. "Direct Comparison of Dietary Portfolio Vs Statin On C-reactive Protein." European Journal of Clinical Nutrition, vol. 59, no. 7, 2005, pp. 851-60.
    Jenkins DJ, Kendall CW, Marchie A, et al. Direct comparison of dietary portfolio vs statin on C-reactive protein. Eur J Clin Nutr. 2005;59(7):851-60.
    Jenkins, D. J., Kendall, C. W., Marchie, A., Faulkner, D. A., Josse, A. R., Wong, J. M., ... Connelly, P. W. (2005). Direct comparison of dietary portfolio vs statin on C-reactive protein. European Journal of Clinical Nutrition, 59(7), pp. 851-60.
    Jenkins DJ, et al. Direct Comparison of Dietary Portfolio Vs Statin On C-reactive Protein. Eur J Clin Nutr. 2005;59(7):851-60. PubMed PMID: 15900306.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Direct comparison of dietary portfolio vs statin on C-reactive protein. AU - Jenkins,D J A, AU - Kendall,C W C, AU - Marchie,A, AU - Faulkner,D A, AU - Josse,A R, AU - Wong,J M W, AU - de Souza,R, AU - Emam,A, AU - Parker,T L, AU - Li,T J, AU - Josse,R G, AU - Leiter,L A, AU - Singer,W, AU - Connelly,P W, PY - 2005/5/19/pubmed PY - 2005/10/14/medline PY - 2005/5/19/entrez SP - 851 EP - 60 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 59 IS - 7 N2 - BACKGROUND: 3-Hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) markedly reduce serum cholesterol and have anti-inflammatory effects. The effect of cholesterol-lowering diets on inflammatory biomarkers is less well known. OBJECTIVE: To compare the efficacy of a dietary combination (portfolio) of cholesterol-lowering foods vs a statin in reducing C-reactive protein (CRP) as a biomarker of inflammation linked to increased cardiovascular disease risk. METHODS: In all, 34 hyperlipidemic subjects completed three 1-month treatments as outpatients in random order: a very low-saturated fat diet (control); the same diet with 20 mg lovastatin (statin); and a diet high in plant sterols (1.0 g/1000 kcal), soy protein (21.4 g/1000 kcal), viscous fibers (9.8 g/1000 kcal), and almonds (14 g/1000 kcal) (portfolio). Fasting blood samples were obtained at weeks 0, 2, and 4. RESULTS: Using the complete data, no treatment reduced serum CRP. However, when subjects with CRP levels above the 75th percentile for previously reported studies (> 3.5 mg/l) were excluded, CRP was reduced similarly on both statin, -16.3 +/- 6.7% (n = 23, P = 0.013) and dietary portfolio, -23.8 +/- 6.9% (n = 25, P = 0.001) but not the control, 15.3 +/- 13.6% (n = 28, P = 0.907). The percentage CRP change from baseline on the portfolio treatment (n = 25) was greater than the control (n = 28, P = 0.004) but similar to statin treatment (n = 23, P = 0.349). Both statin and portfolio treatments were similar in reducing CRP and numerically more effective than control but only the change in portfolio was significant after the Bonferroni adjustment. CONCLUSIONS: A combination of cholesterol-lowering foods reduced C-reactive protein to a similar extent as the starting dose of a first-generation statin. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/15900306/Direct_comparison_of_dietary_portfolio_vs_statin_on_C_reactive_protein_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1602152 DB - PRIME DP - Unbound Medicine ER -