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[Serotype distribution of enteroviruses isolated from paediatric cases prediagnosed as aseptic meningitis between 2001-2004 period].
Mikrobiyol Bul. 2005 Jan; 39(1):43-51.MB

Abstract

Enteroviruses have major clinical and public health importance and are one of the leading causes of aseptic meningitis. There are many diseases with similar clinical symptoms and cerebrospinal fluid (CSF) findings of aseptic meningitis, thus virus isolation and identification is crucial for definitive diagnosis. Virological diagnosis is nonetheless important to distinguish between induced meningitis and other treatable causes of disease with a similar clinical picture. A total of 249 samples obtained from 246 cases (age range: 0-15 years), prediagnosed as aseptic meningitis, were sent to Virology Laboratory of Refik Saydam Hygiene Center. The patients were followed at Department of Pediatric Infectious Diseases in the Social Security Hospital, Ankara, Turkey, between 2001 and 2004. Stool (n: 180), CSF (n: 54) and throat swab (n: 15) samples have been inoculated to RD (rhabdomyosarcoma), Hep-2 (human epithelioma) and L20B (transgenic mice) cell lines, and followed up for the presence of cytopathic effects. A total of 95 enterovirus strains were isolated from 85 (34.6%) cases, and serotyped by using RIVM (National Institute of Public and the Environment, Nederlands) antisera with microneutralization method. As a result, the most frequently isolated types were found as echovirus type 30 (n: 24) and coxsackievirus type B (n: 19), which were most frequently isolated between July to October. This is the first report from Turkey for aseptic meningitis cases due to echovirus type 25 (n:3), 18 (n:2), 14 (n:1), 13 (n:4), 11 (n:6), 9 (n:1), 6 (n:9), 5 (n:1), 4 (n:1) and coxsackievirus type A9 (n:1).

Authors+Show Affiliations

Ozkaya E
Refik Saydam Hifzissihha Merkezi Başkanligi, Viroloji, Hücre Kültürü ve Enterovirus Laboratuvari, Ankara.
Uysal G
No affiliation info available
Atak T
No affiliation info available
Alkan M
No affiliation info available

MeSH

AdolescentCell LineCell Line, TumorCerebrospinal FluidChildChild, PreschoolCytopathogenic Effect, ViralEnterovirusEnterovirus B, HumanEnterovirus InfectionsFecesHumansInfantInfant, NewbornMeningitis, AsepticMeningitis, ViralPharynxSerotypingTurkey

Pub Type(s)

English Abstract
Journal Article

Language

tur

PubMed ID

15900836

Citation

Ozkaya, Etem, et al. "[Serotype Distribution of Enteroviruses Isolated From Paediatric Cases Prediagnosed as Aseptic Meningitis Between 2001-2004 Period]." Mikrobiyoloji Bulteni, vol. 39, no. 1, 2005, pp. 43-51.
Ozkaya E, Uysal G, Atak T, et al. [Serotype distribution of enteroviruses isolated from paediatric cases prediagnosed as aseptic meningitis between 2001-2004 period]. Mikrobiyol Bul. 2005;39(1):43-51.
Ozkaya, E., Uysal, G., Atak, T., & Alkan, M. (2005). [Serotype distribution of enteroviruses isolated from paediatric cases prediagnosed as aseptic meningitis between 2001-2004 period]. Mikrobiyoloji Bulteni, 39(1), 43-51.
Ozkaya E, et al. [Serotype Distribution of Enteroviruses Isolated From Paediatric Cases Prediagnosed as Aseptic Meningitis Between 2001-2004 Period]. Mikrobiyol Bul. 2005;39(1):43-51. PubMed PMID: 15900836.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Serotype distribution of enteroviruses isolated from paediatric cases prediagnosed as aseptic meningitis between 2001-2004 period]. AU - Ozkaya,Etem, AU - Uysal,Gülnar, AU - Atak,Tunca, AU - Alkan,Mehmet, PY - 2005/5/20/pubmed PY - 2006/5/31/medline PY - 2005/5/20/entrez SP - 43 EP - 51 JF - Mikrobiyoloji bulteni JO - Mikrobiyol Bul VL - 39 IS - 1 N2 - Enteroviruses have major clinical and public health importance and are one of the leading causes of aseptic meningitis. There are many diseases with similar clinical symptoms and cerebrospinal fluid (CSF) findings of aseptic meningitis, thus virus isolation and identification is crucial for definitive diagnosis. Virological diagnosis is nonetheless important to distinguish between induced meningitis and other treatable causes of disease with a similar clinical picture. A total of 249 samples obtained from 246 cases (age range: 0-15 years), prediagnosed as aseptic meningitis, were sent to Virology Laboratory of Refik Saydam Hygiene Center. The patients were followed at Department of Pediatric Infectious Diseases in the Social Security Hospital, Ankara, Turkey, between 2001 and 2004. Stool (n: 180), CSF (n: 54) and throat swab (n: 15) samples have been inoculated to RD (rhabdomyosarcoma), Hep-2 (human epithelioma) and L20B (transgenic mice) cell lines, and followed up for the presence of cytopathic effects. A total of 95 enterovirus strains were isolated from 85 (34.6%) cases, and serotyped by using RIVM (National Institute of Public and the Environment, Nederlands) antisera with microneutralization method. As a result, the most frequently isolated types were found as echovirus type 30 (n: 24) and coxsackievirus type B (n: 19), which were most frequently isolated between July to October. This is the first report from Turkey for aseptic meningitis cases due to echovirus type 25 (n:3), 18 (n:2), 14 (n:1), 13 (n:4), 11 (n:6), 9 (n:1), 6 (n:9), 5 (n:1), 4 (n:1) and coxsackievirus type A9 (n:1). SN - 0374-9096 UR - https://www.unboundmedicine.com/medline/citation/15900836/[Serotype_distribution_of_enteroviruses_isolated_from_paediatric_cases_prediagnosed_as_aseptic_meningitis_between_2001_2004_period]_ DB - PRIME DP - Unbound Medicine ER -