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Cotranscriptional mRNP assembly: from the DNA to the nuclear pore.
Curr Opin Cell Biol. 2005 Jun; 17(3):242-50.CO

Abstract

Transcription is coupled with the concomitant assembly of RNA-binding proteins to the nascent mRNA to generate a stable and export-competent mRNP particle. RNA-binding factors recruited at active transcription sites specify the processing, nuclear export, subcellular localization, translation and stability of the mRNA. The assembly of the mRNP particle starts with the association of the cap-binding protein complex followed by the splicing-dependent assembly of the exon-junction complex in intron-containing genes and by the binding of RNA-export adaptor proteins. New findings suggest that mRNP assembly is a genetically controlled process that plays a key role in gene expression and other cellular processes, including the maintenance of genome integrity.

Authors+Show Affiliations

Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Avd. Reina Mercedes 6, 41012 Sevilla, Spain. aguilo@us.es

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

15901492

Citation

Aguilera, Andrés. "Cotranscriptional mRNP Assembly: From the DNA to the Nuclear Pore." Current Opinion in Cell Biology, vol. 17, no. 3, 2005, pp. 242-50.
Aguilera A. Cotranscriptional mRNP assembly: from the DNA to the nuclear pore. Curr Opin Cell Biol. 2005;17(3):242-50.
Aguilera, A. (2005). Cotranscriptional mRNP assembly: from the DNA to the nuclear pore. Current Opinion in Cell Biology, 17(3), 242-50.
Aguilera A. Cotranscriptional mRNP Assembly: From the DNA to the Nuclear Pore. Curr Opin Cell Biol. 2005;17(3):242-50. PubMed PMID: 15901492.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cotranscriptional mRNP assembly: from the DNA to the nuclear pore. A1 - Aguilera,Andrés, PY - 2005/5/20/pubmed PY - 2005/9/13/medline PY - 2005/5/20/entrez SP - 242 EP - 50 JF - Current opinion in cell biology JO - Curr Opin Cell Biol VL - 17 IS - 3 N2 - Transcription is coupled with the concomitant assembly of RNA-binding proteins to the nascent mRNA to generate a stable and export-competent mRNP particle. RNA-binding factors recruited at active transcription sites specify the processing, nuclear export, subcellular localization, translation and stability of the mRNA. The assembly of the mRNP particle starts with the association of the cap-binding protein complex followed by the splicing-dependent assembly of the exon-junction complex in intron-containing genes and by the binding of RNA-export adaptor proteins. New findings suggest that mRNP assembly is a genetically controlled process that plays a key role in gene expression and other cellular processes, including the maintenance of genome integrity. SN - 0955-0674 UR - https://www.unboundmedicine.com/medline/citation/15901492/Cotranscriptional_mRNP_assembly:_from_the_DNA_to_the_nuclear_pore_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0955-0674(05)00041-4 DB - PRIME DP - Unbound Medicine ER -