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Formation of export-competent mRNP: escaping nuclear destruction.
Curr Opin Cell Biol. 2005 Jun; 17(3):287-93.CO

Abstract

In eukaryotic cells, primary transcripts are processed and bound by proteins before export to the cytoplasm. Nuclear production of export-competent messenger ribonucleoprotein particles (mRNPs) is a complicated process, and mRNP biogenic events that function sub-optimally are rapidly attacked by surveillance leading to degradation of the mRNA. Export of nuclear mRNAs is therefore constantly challenged by the opposing force of mRNA retention and decay. This balance ensures that only 'perfect' transcripts persist, and that non-functional and potentially deleterious transcripts are removed early in their biogenesis. Thus, eukaryotic systems of mRNP quality control can be viewed as simple Darwinian principles operating at the molecular level.

Authors+Show Affiliations

Department of Molecular Biology, Arhus University, CF Møllers Alle, bldg. 130, 8000 Arhus C, Denmark.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

15901499

Citation

Saguez, Cyril, et al. "Formation of Export-competent mRNP: Escaping Nuclear Destruction." Current Opinion in Cell Biology, vol. 17, no. 3, 2005, pp. 287-93.
Saguez C, Olesen JR, Jensen TH. Formation of export-competent mRNP: escaping nuclear destruction. Curr Opin Cell Biol. 2005;17(3):287-93.
Saguez, C., Olesen, J. R., & Jensen, T. H. (2005). Formation of export-competent mRNP: escaping nuclear destruction. Current Opinion in Cell Biology, 17(3), 287-93.
Saguez C, Olesen JR, Jensen TH. Formation of Export-competent mRNP: Escaping Nuclear Destruction. Curr Opin Cell Biol. 2005;17(3):287-93. PubMed PMID: 15901499.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Formation of export-competent mRNP: escaping nuclear destruction. AU - Saguez,Cyril, AU - Olesen,Jens Raabjerg, AU - Jensen,Torben Heick, PY - 2005/5/20/pubmed PY - 2005/9/13/medline PY - 2005/5/20/entrez SP - 287 EP - 93 JF - Current opinion in cell biology JO - Curr Opin Cell Biol VL - 17 IS - 3 N2 - In eukaryotic cells, primary transcripts are processed and bound by proteins before export to the cytoplasm. Nuclear production of export-competent messenger ribonucleoprotein particles (mRNPs) is a complicated process, and mRNP biogenic events that function sub-optimally are rapidly attacked by surveillance leading to degradation of the mRNA. Export of nuclear mRNAs is therefore constantly challenged by the opposing force of mRNA retention and decay. This balance ensures that only 'perfect' transcripts persist, and that non-functional and potentially deleterious transcripts are removed early in their biogenesis. Thus, eukaryotic systems of mRNP quality control can be viewed as simple Darwinian principles operating at the molecular level. SN - 0955-0674 UR - https://www.unboundmedicine.com/medline/citation/15901499/Formation_of_export_competent_mRNP:_escaping_nuclear_destruction_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0955-0674(05)00051-7 DB - PRIME DP - Unbound Medicine ER -