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Quality control of messenger ribonucleoprotein particles in the nucleus and at the pore.
Curr Opin Cell Biol. 2005 Jun; 17(3):294-301.CO

Abstract

The spatial separation of nuclear transcription and cytoplasmic translation in eukaryotic cells implies that mRNAs have to travel. On their journey, proteins involved in the various steps of transcript formation, processing and transport dynamically interact with mRNAs to form diverse messenger ribonucleoprotein complexes (mRNPs). Increasing evidence indicates that the protein complexes involved in distinct phases of manufacturing a bona fide mRNA in the nucleus are tightly coupled. Moreover, the recent demonstration that active genes migrate into preassembled, shared nuclear sub-compartments suggests that mRNAs are churned out in large 'transcription factories' with distinct but interconnected divisions. Nuclear factors have now been identified that specifically control the quality of mRNAs without affecting mRNP biogenesis or export.

Authors+Show Affiliations

Unité de Biologie Cellulaire du Noyau, Institut Pasteur, 28 rue du Dr Roux, 75015 Paris, France.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

15901500

Citation

Sommer, Peter, and Ulf Nehrbass. "Quality Control of Messenger Ribonucleoprotein Particles in the Nucleus and at the Pore." Current Opinion in Cell Biology, vol. 17, no. 3, 2005, pp. 294-301.
Sommer P, Nehrbass U. Quality control of messenger ribonucleoprotein particles in the nucleus and at the pore. Curr Opin Cell Biol. 2005;17(3):294-301.
Sommer, P., & Nehrbass, U. (2005). Quality control of messenger ribonucleoprotein particles in the nucleus and at the pore. Current Opinion in Cell Biology, 17(3), 294-301.
Sommer P, Nehrbass U. Quality Control of Messenger Ribonucleoprotein Particles in the Nucleus and at the Pore. Curr Opin Cell Biol. 2005;17(3):294-301. PubMed PMID: 15901500.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quality control of messenger ribonucleoprotein particles in the nucleus and at the pore. AU - Sommer,Peter, AU - Nehrbass,Ulf, PY - 2005/5/20/pubmed PY - 2005/9/13/medline PY - 2005/5/20/entrez SP - 294 EP - 301 JF - Current opinion in cell biology JO - Curr Opin Cell Biol VL - 17 IS - 3 N2 - The spatial separation of nuclear transcription and cytoplasmic translation in eukaryotic cells implies that mRNAs have to travel. On their journey, proteins involved in the various steps of transcript formation, processing and transport dynamically interact with mRNAs to form diverse messenger ribonucleoprotein complexes (mRNPs). Increasing evidence indicates that the protein complexes involved in distinct phases of manufacturing a bona fide mRNA in the nucleus are tightly coupled. Moreover, the recent demonstration that active genes migrate into preassembled, shared nuclear sub-compartments suggests that mRNAs are churned out in large 'transcription factories' with distinct but interconnected divisions. Nuclear factors have now been identified that specifically control the quality of mRNAs without affecting mRNP biogenesis or export. SN - 0955-0674 UR - https://www.unboundmedicine.com/medline/citation/15901500/Quality_control_of_messenger_ribonucleoprotein_particles_in_the_nucleus_and_at_the_pore_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0955-0674(05)00049-9 DB - PRIME DP - Unbound Medicine ER -