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Metabolic syndrome and the risk for chronic kidney disease among nondiabetic adults.
J Am Soc Nephrol. 2005 Jul; 16(7):2134-40.JA

Abstract

The metabolic syndrome is a risk factor for the development of diabetes and cardiovascular disease; however, no prospective studies have examined the metabolic syndrome as a risk factor for chronic kidney disease (CKD). A total of 10,096 nondiabetic participants who were in the Atherosclerosis Risk in Communities study and had normal baseline kidney function composed the study cohort. The metabolic syndrome was defined according to recent guidelines from the National Cholesterol Education Program. Incident CKD was defined as an estimated GFR (eGFR) <60 ml/min per 1.73 m2 at study year 9 among those with an eGFR > or =60 ml/min per 1.73 m2 at baseline. After 9 yr of follow-up, 691 (7%) participants developed CKD. The multivariable adjusted odds ratio (OR) of developing CKD in participants with the metabolic syndrome was 1.43 (95% confidence interval [CI], 1.18 to 1.73). Compared with participants with no traits of the metabolic syndrome, those with one, two, three, four, or five traits of the metabolic syndrome had OR of CKD of 1.13 (95% CI, 0.89 to 1.45), 1.53 (95% CI, 1.18 to 1.98), 1.75 (95% CI, 1.32 to 2.33), 1.84 (95% CI, 1.27 to 2.67), and 2.45 (95% CI, 1.32 to 4.54), respectively. After adjusting for the subsequent development of diabetes and hypertension during the 9 yr of follow-up, the OR of incident CKD among participants with the metabolic syndrome was 1.24 (95% CI, 1.01 to 1.51). The metabolic syndrome is independently associated with an increased risk for incident CKD in nondiabetic adults.

Authors+Show Affiliations

University of California San Francisco, Department of Nephrology, Laurel Heights, 3333 California Street, Suite 430, San Francisco, CA 94118-1211, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15901764

Citation

Kurella, Manjula, et al. "Metabolic Syndrome and the Risk for Chronic Kidney Disease Among Nondiabetic Adults." Journal of the American Society of Nephrology : JASN, vol. 16, no. 7, 2005, pp. 2134-40.
Kurella M, Lo JC, Chertow GM. Metabolic syndrome and the risk for chronic kidney disease among nondiabetic adults. J Am Soc Nephrol. 2005;16(7):2134-40.
Kurella, M., Lo, J. C., & Chertow, G. M. (2005). Metabolic syndrome and the risk for chronic kidney disease among nondiabetic adults. Journal of the American Society of Nephrology : JASN, 16(7), 2134-40.
Kurella M, Lo JC, Chertow GM. Metabolic Syndrome and the Risk for Chronic Kidney Disease Among Nondiabetic Adults. J Am Soc Nephrol. 2005;16(7):2134-40. PubMed PMID: 15901764.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metabolic syndrome and the risk for chronic kidney disease among nondiabetic adults. AU - Kurella,Manjula, AU - Lo,Joan C, AU - Chertow,Glenn M, Y1 - 2005/05/18/ PY - 2005/5/20/pubmed PY - 2005/11/16/medline PY - 2005/5/20/entrez SP - 2134 EP - 40 JF - Journal of the American Society of Nephrology : JASN JO - J Am Soc Nephrol VL - 16 IS - 7 N2 - The metabolic syndrome is a risk factor for the development of diabetes and cardiovascular disease; however, no prospective studies have examined the metabolic syndrome as a risk factor for chronic kidney disease (CKD). A total of 10,096 nondiabetic participants who were in the Atherosclerosis Risk in Communities study and had normal baseline kidney function composed the study cohort. The metabolic syndrome was defined according to recent guidelines from the National Cholesterol Education Program. Incident CKD was defined as an estimated GFR (eGFR) <60 ml/min per 1.73 m2 at study year 9 among those with an eGFR > or =60 ml/min per 1.73 m2 at baseline. After 9 yr of follow-up, 691 (7%) participants developed CKD. The multivariable adjusted odds ratio (OR) of developing CKD in participants with the metabolic syndrome was 1.43 (95% confidence interval [CI], 1.18 to 1.73). Compared with participants with no traits of the metabolic syndrome, those with one, two, three, four, or five traits of the metabolic syndrome had OR of CKD of 1.13 (95% CI, 0.89 to 1.45), 1.53 (95% CI, 1.18 to 1.98), 1.75 (95% CI, 1.32 to 2.33), 1.84 (95% CI, 1.27 to 2.67), and 2.45 (95% CI, 1.32 to 4.54), respectively. After adjusting for the subsequent development of diabetes and hypertension during the 9 yr of follow-up, the OR of incident CKD among participants with the metabolic syndrome was 1.24 (95% CI, 1.01 to 1.51). The metabolic syndrome is independently associated with an increased risk for incident CKD in nondiabetic adults. SN - 1046-6673 UR - https://www.unboundmedicine.com/medline/citation/15901764/Metabolic_syndrome_and_the_risk_for_chronic_kidney_disease_among_nondiabetic_adults_ L2 - https://jasn.asnjournals.org/cgi/pmidlookup?view=long&amp;pmid=15901764 DB - PRIME DP - Unbound Medicine ER -