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Genetic variants of myeloperoxidase and catechol-O-methyltransferase and breast cancer risk.
Eur J Cancer Prev 2005; 14(3):257-61EJ

Abstract

This nested case-control study evaluated the role of polymorphisms in the myeloperoxidase (MPO) and catechol-O-methyltransferase (COMT) genes that modulate oxidative stress in breast cancer risk in a Chinese population. Our results demonstrate that the MPO A/A genotype was associated with a reduced risk of breast cancer (odds ratio (OR) 0.64; 95% confidence interval (CI) 0.11-3.76), whereas there was no overall association of COMT genotype with breast cancer. Of note, an elevated breast cancer risk associated with the increasing numbers of high-risk genotypes of MPO and COMT genes was observed in women with a longer duration between menarche and first full-term pregnancy.

Authors+Show Affiliations

School of Public Health, National Defense Medical Center, No. 161, Section 6 Min-Chuan East Road, Taipei 114, Taiwan, Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15901995

Citation

Lin, S-C, et al. "Genetic Variants of Myeloperoxidase and catechol-O-methyltransferase and Breast Cancer Risk." European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP), vol. 14, no. 3, 2005, pp. 257-61.
Lin SC, Chou YC, Wu MH, et al. Genetic variants of myeloperoxidase and catechol-O-methyltransferase and breast cancer risk. Eur J Cancer Prev. 2005;14(3):257-61.
Lin, S. C., Chou, Y. C., Wu, M. H., Wu, C. C., Lin, W. Y., Yu, C. P., ... Sun, C. A. (2005). Genetic variants of myeloperoxidase and catechol-O-methyltransferase and breast cancer risk. European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP), 14(3), pp. 257-61.
Lin SC, et al. Genetic Variants of Myeloperoxidase and catechol-O-methyltransferase and Breast Cancer Risk. Eur J Cancer Prev. 2005;14(3):257-61. PubMed PMID: 15901995.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic variants of myeloperoxidase and catechol-O-methyltransferase and breast cancer risk. AU - Lin,S-C, AU - Chou,Y-C, AU - Wu,M-H, AU - Wu,C-C, AU - Lin,W-Y, AU - Yu,C-P, AU - Yu,J-C, AU - You,S-L, AU - Chen,C-J, AU - Sun,C-A, PY - 2005/5/20/pubmed PY - 2005/10/20/medline PY - 2005/5/20/entrez SP - 257 EP - 61 JF - European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) JO - Eur. J. Cancer Prev. VL - 14 IS - 3 N2 - This nested case-control study evaluated the role of polymorphisms in the myeloperoxidase (MPO) and catechol-O-methyltransferase (COMT) genes that modulate oxidative stress in breast cancer risk in a Chinese population. Our results demonstrate that the MPO A/A genotype was associated with a reduced risk of breast cancer (odds ratio (OR) 0.64; 95% confidence interval (CI) 0.11-3.76), whereas there was no overall association of COMT genotype with breast cancer. Of note, an elevated breast cancer risk associated with the increasing numbers of high-risk genotypes of MPO and COMT genes was observed in women with a longer duration between menarche and first full-term pregnancy. SN - 0959-8278 UR - https://www.unboundmedicine.com/medline/citation/15901995/Genetic_variants_of_myeloperoxidase_and_catechol_O_methyltransferase_and_breast_cancer_risk_ L2 - http://dx.doi.org/10.1097/00008469-200506000-00010 DB - PRIME DP - Unbound Medicine ER -