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Acute fatty liver of pregnancy in 3 tertiary care centers.
Am J Obstet Gynecol. 2005 May; 192(5):1416-9.AJ

Abstract

OBJECTIVE

The purpose of this study was to determine the demographics, clinical presentation, and maternal and neonatal outcomes in patients who were diagnosed with acute fatty liver of pregnancy over a 10-year period.

STUDY DESIGN

This was a multicenter retrospective study of women with the diagnosis of acute fatty liver of pregnancy. Records were reviewed for symptoms, laboratory findings, clinical course, and maternal and perinatal outcomes.

RESULTS

Sixteen cases of acute fatty liver of pregnancy were identified. Three of the 16 cases had multiple gestations (18%). Eleven of the 16 cases were diagnosed in the antepartum period, and 5 cases were diagnosed within 4 days after delivery. Nausea and vomiting were the most common symptoms (75%). There were 2 maternal deaths (12.5%) and 3 fetal deaths (15%).

CONCLUSION

We recommend that patients with persistent nausea, vomiting, or epigastric pain in the third trimester receive evaluation of liver enzymes, renal function, and a complete blood count to rule out the diagnosis of acute fatty liver of pregnancy.

Authors+Show Affiliations

Fesenmeier MF
Department of Obstetrics and Gynecology, University of Cincinnati, Ohio 45267-0526, USA.
Coppage KH
No affiliation info available
Lambers DS
No affiliation info available
Barton JR
No affiliation info available
Sibai BM
No affiliation info available

MeSH

Acute DiseaseAdolescentAdultFatty LiverFemaleFetal MortalityGestational AgeHumansIncidencePostpartum PeriodPregnancyPregnancy ComplicationsPregnancy OutcomePregnancy, MultipleRetrospective Studies

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

15902124

Citation

Fesenmeier, Michael F., et al. "Acute Fatty Liver of Pregnancy in 3 Tertiary Care Centers." American Journal of Obstetrics and Gynecology, vol. 192, no. 5, 2005, pp. 1416-9.
Fesenmeier MF, Coppage KH, Lambers DS, et al. Acute fatty liver of pregnancy in 3 tertiary care centers. Am J Obstet Gynecol. 2005;192(5):1416-9.
Fesenmeier, M. F., Coppage, K. H., Lambers, D. S., Barton, J. R., & Sibai, B. M. (2005). Acute fatty liver of pregnancy in 3 tertiary care centers. American Journal of Obstetrics and Gynecology, 192(5), 1416-9.
Fesenmeier MF, et al. Acute Fatty Liver of Pregnancy in 3 Tertiary Care Centers. Am J Obstet Gynecol. 2005;192(5):1416-9. PubMed PMID: 15902124.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute fatty liver of pregnancy in 3 tertiary care centers. AU - Fesenmeier,Michael F, AU - Coppage,Kristin H, AU - Lambers,Donna S, AU - Barton,John R, AU - Sibai,Baha M, PY - 2005/5/20/pubmed PY - 2005/6/25/medline PY - 2005/5/20/entrez SP - 1416 EP - 9 JF - American journal of obstetrics and gynecology JO - Am J Obstet Gynecol VL - 192 IS - 5 N2 - OBJECTIVE: The purpose of this study was to determine the demographics, clinical presentation, and maternal and neonatal outcomes in patients who were diagnosed with acute fatty liver of pregnancy over a 10-year period. STUDY DESIGN: This was a multicenter retrospective study of women with the diagnosis of acute fatty liver of pregnancy. Records were reviewed for symptoms, laboratory findings, clinical course, and maternal and perinatal outcomes. RESULTS: Sixteen cases of acute fatty liver of pregnancy were identified. Three of the 16 cases had multiple gestations (18%). Eleven of the 16 cases were diagnosed in the antepartum period, and 5 cases were diagnosed within 4 days after delivery. Nausea and vomiting were the most common symptoms (75%). There were 2 maternal deaths (12.5%) and 3 fetal deaths (15%). CONCLUSION: We recommend that patients with persistent nausea, vomiting, or epigastric pain in the third trimester receive evaluation of liver enzymes, renal function, and a complete blood count to rule out the diagnosis of acute fatty liver of pregnancy. SN - 0002-9378 UR - https://www.unboundmedicine.com/medline/citation/15902124/Acute_fatty_liver_of_pregnancy_in_3_tertiary_care_centers_ DB - PRIME DP - Unbound Medicine ER -