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Six-year follow-up of pancreatic beta cell function in adults with latent autoimmune diabetes.
World J Gastroenterol. 2005 May 21; 11(19):2900-5.WJ

Abstract

AIM

To investigate the characteristics of the progression of islet beta cell function in Chinese latent autoimmune diabetes in adult (LADA) patients with glutamic acid decarboxylase antibody (GAD-Ab) positivity, and to explore the prognostic factors for beta cell function.

METHODS

Forty-five LADA patients with GAD-Ab positivity screened from phenotypic type 2 diabetic (T2DM) patients and 45 T2DM patients without GAD-Ab matched as controls were followed-up every 6 mo. Sixteen patients in LADA1 and T2DM1 groups respectively have been followed-up for 6 years, while 29 patients in LADA2 and T2DM2 groups respectively for only 1.5 years. GAD-Ab was determined by radioligand assay, and C-peptides (CP) by radioimmune assay.

RESULTS

The percentage of patients whose fasting CP (FCP) decreased more than 50% compared with the baseline reached to 25.0% at 1.5(th) year in LADA1 group, and FCP level decreased (395.8+/-71.5 vs 572.8+/-72.3 pmol/L, P<0.05) at 2.5(th) year and continuously went down to the end of follow-up. No significant changes of the above parameters were found in T2DM1 group. The average decreased percentages of FCP per year in LADA and T2DM patients were 15.8% (4.0-91.0%) and 5.2% (-3.5 to 35.5%, P=0.000) respectively. The index of GAD-Ab was negatively correlated with the FCP in LADA patients (r(s)=-0.483, P=0.000). The decreased percentage of FCP per year in LADA patients were correlated with GAD-Ab index, body mass index (BMI) and age at onset (r(s)=0.408, -0.301 and -0.523 respectively, P<0.05). Moreover, GAD-Ab was the only risk factor for predicting beta cell failure in LADA patients (B=1.455, EXP (B)=4.283, P=0.023).

CONCLUSION

The decreasing rate of islet beta cell function in LADA, being highly heterogeneous, is three times that of T2DM patients. The titer of GAD-Ab is an important predictor for the progression of islet beta cell function, and age at onset and BMI could also act as the predictors.

Authors+Show Affiliations

Institute of Metabolism and Endocrinology, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15902725

Citation

Yang, Lin, et al. "Six-year Follow-up of Pancreatic Beta Cell Function in Adults With Latent Autoimmune Diabetes." World Journal of Gastroenterology, vol. 11, no. 19, 2005, pp. 2900-5.
Yang L, Zhou ZG, Huang G, et al. Six-year follow-up of pancreatic beta cell function in adults with latent autoimmune diabetes. World J Gastroenterol. 2005;11(19):2900-5.
Yang, L., Zhou, Z. G., Huang, G., Ouyang, L. L., Li, X., & Yan, X. (2005). Six-year follow-up of pancreatic beta cell function in adults with latent autoimmune diabetes. World Journal of Gastroenterology, 11(19), 2900-5.
Yang L, et al. Six-year Follow-up of Pancreatic Beta Cell Function in Adults With Latent Autoimmune Diabetes. World J Gastroenterol. 2005 May 21;11(19):2900-5. PubMed PMID: 15902725.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Six-year follow-up of pancreatic beta cell function in adults with latent autoimmune diabetes. AU - Yang,Lin, AU - Zhou,Zhi-Guang, AU - Huang,Gan, AU - Ouyang,Ling-Li, AU - Li,Xia, AU - Yan,Xiang, PY - 2005/5/20/pubmed PY - 2005/6/29/medline PY - 2005/5/20/entrez SP - 2900 EP - 5 JF - World journal of gastroenterology JO - World J Gastroenterol VL - 11 IS - 19 N2 - AIM: To investigate the characteristics of the progression of islet beta cell function in Chinese latent autoimmune diabetes in adult (LADA) patients with glutamic acid decarboxylase antibody (GAD-Ab) positivity, and to explore the prognostic factors for beta cell function. METHODS: Forty-five LADA patients with GAD-Ab positivity screened from phenotypic type 2 diabetic (T2DM) patients and 45 T2DM patients without GAD-Ab matched as controls were followed-up every 6 mo. Sixteen patients in LADA1 and T2DM1 groups respectively have been followed-up for 6 years, while 29 patients in LADA2 and T2DM2 groups respectively for only 1.5 years. GAD-Ab was determined by radioligand assay, and C-peptides (CP) by radioimmune assay. RESULTS: The percentage of patients whose fasting CP (FCP) decreased more than 50% compared with the baseline reached to 25.0% at 1.5(th) year in LADA1 group, and FCP level decreased (395.8+/-71.5 vs 572.8+/-72.3 pmol/L, P<0.05) at 2.5(th) year and continuously went down to the end of follow-up. No significant changes of the above parameters were found in T2DM1 group. The average decreased percentages of FCP per year in LADA and T2DM patients were 15.8% (4.0-91.0%) and 5.2% (-3.5 to 35.5%, P=0.000) respectively. The index of GAD-Ab was negatively correlated with the FCP in LADA patients (r(s)=-0.483, P=0.000). The decreased percentage of FCP per year in LADA patients were correlated with GAD-Ab index, body mass index (BMI) and age at onset (r(s)=0.408, -0.301 and -0.523 respectively, P<0.05). Moreover, GAD-Ab was the only risk factor for predicting beta cell failure in LADA patients (B=1.455, EXP (B)=4.283, P=0.023). CONCLUSION: The decreasing rate of islet beta cell function in LADA, being highly heterogeneous, is three times that of T2DM patients. The titer of GAD-Ab is an important predictor for the progression of islet beta cell function, and age at onset and BMI could also act as the predictors. SN - 1007-9327 UR - https://www.unboundmedicine.com/medline/citation/15902725/Six_year_follow_up_of_pancreatic_beta_cell_function_in_adults_with_latent_autoimmune_diabetes_ L2 - https://www.wjgnet.com/1007-9327/full/v11/i19/2900.htm DB - PRIME DP - Unbound Medicine ER -