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A mass vaccination campaign targeting adults and children to prevent typhoid fever in Hechi; expanding the use of Vi polysaccharide vaccine in southeast China: a cluster-randomized trial.
BMC Public Health. 2005 May 18; 5:49.BP

Abstract

BACKGROUND

One of the goals of this study was to learn the coverage, safety and logistics of a mass vaccination campaign against typhoid fever in children and adults using locally produced typhoid Vi polysaccharide (PS) and group A meningococcal PS vaccines in southern China.

METHODS

The vaccination campaign targeted 118,588 persons in Hechi, Guangxi Province, aged between 5 to 60 years, in 2003. The study area was divided into 107 geographic clusters, which were randomly allocated to receive one of the single-dose parenteral vaccines. All aspects regarding vaccination logistics, feasibility and safety were documented and systematically recorded. Results of the logistics, feasibility and safety are reported.

RESULTS

The campaign lasted 5 weeks and the overall vaccination coverage was 78%. On average, the 30 vaccine teams gave immunizations on 23 days. Vaccine rates were higher in those aged < or = 15 years (90%) than in adolescents and young adults (70%). Planned mop-up activities increased the coverage by 17%. The overall vaccine wastage was 11%. The cold chain was maintained and documented. 66 individuals reported of adverse events out of all vaccinees, where fever (21%), malaise (19%) and local redness (19%) were the major symptoms; no life-threatening event occurred. Three needle-sharp events were reported.

CONCLUSION

The mass immunization proved feasible and safe, and vaccine coverage was high. Emphasis should be placed on: injection safety measures, community involvement and incorporation of mop-up strategies into any vaccination campaign. School-based and all-age Vi mass immunizations programs are potentially important public health strategies for prevention of typhoid fever in high-risk populations in southern China.

Authors+Show Affiliations

Division of Bacterial Diseases, Guangxi Center for Disease Control, 80 Taoyuan Road, Nanning 530021, Guangxi, China. yyyjin@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15904514

Citation

Yang, Jin, et al. "A Mass Vaccination Campaign Targeting Adults and Children to Prevent Typhoid Fever in Hechi; Expanding the Use of Vi Polysaccharide Vaccine in Southeast China: a Cluster-randomized Trial." BMC Public Health, vol. 5, 2005, p. 49.
Yang J, Acosta CJ, Si GA, et al. A mass vaccination campaign targeting adults and children to prevent typhoid fever in Hechi; expanding the use of Vi polysaccharide vaccine in southeast China: a cluster-randomized trial. BMC Public Health. 2005;5:49.
Yang, J., Acosta, C. J., Si, G. A., Zeng, J., Li, C. Y., Liang, D. B., Ochiai, R. L., Page, A. L., Danovaro-Holliday, M. C., Zhang, J., Zhou, B. D., Liao, H. Z., Wang, M. L., Tan, D. M., Tang, Z. Z., Gong, J., Park, J. K., Ali, M., Ivanoff, B., ... Clemens, J. D. (2005). A mass vaccination campaign targeting adults and children to prevent typhoid fever in Hechi; expanding the use of Vi polysaccharide vaccine in southeast China: a cluster-randomized trial. BMC Public Health, 5, 49.
Yang J, et al. A Mass Vaccination Campaign Targeting Adults and Children to Prevent Typhoid Fever in Hechi; Expanding the Use of Vi Polysaccharide Vaccine in Southeast China: a Cluster-randomized Trial. BMC Public Health. 2005 May 18;5:49. PubMed PMID: 15904514.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A mass vaccination campaign targeting adults and children to prevent typhoid fever in Hechi; expanding the use of Vi polysaccharide vaccine in southeast China: a cluster-randomized trial. AU - Yang,Jin, AU - Acosta,Camilo J, AU - Si,Guo-ai, AU - Zeng,Jun, AU - Li,Cui-yun, AU - Liang,Da-bin, AU - Ochiai,R Leon, AU - Page,Anne-Laure, AU - Danovaro-Holliday,M Carolina, AU - Zhang,Jie, AU - Zhou,Bao-de, AU - Liao,He-zhuang, AU - Wang,Ming-liu, AU - Tan,Dong-mei, AU - Tang,Zhen-zhu, AU - Gong,Jian, AU - Park,Jin-kyung, AU - Ali,Mohammad, AU - Ivanoff,Bernard, AU - Liang,Gui-chen, AU - Yang,Hong-hui, AU - Pang,Tikki, AU - Xu,Zhi-yi, AU - Donner,Allan, AU - Galindo,Claudia M, AU - Dong,Bai-qing, AU - Clemens,John D, Y1 - 2005/05/18/ PY - 2004/12/28/received PY - 2005/05/18/accepted PY - 2005/5/21/pubmed PY - 2006/1/20/medline PY - 2005/5/21/entrez SP - 49 EP - 49 JF - BMC public health JO - BMC Public Health VL - 5 N2 - BACKGROUND: One of the goals of this study was to learn the coverage, safety and logistics of a mass vaccination campaign against typhoid fever in children and adults using locally produced typhoid Vi polysaccharide (PS) and group A meningococcal PS vaccines in southern China. METHODS: The vaccination campaign targeted 118,588 persons in Hechi, Guangxi Province, aged between 5 to 60 years, in 2003. The study area was divided into 107 geographic clusters, which were randomly allocated to receive one of the single-dose parenteral vaccines. All aspects regarding vaccination logistics, feasibility and safety were documented and systematically recorded. Results of the logistics, feasibility and safety are reported. RESULTS: The campaign lasted 5 weeks and the overall vaccination coverage was 78%. On average, the 30 vaccine teams gave immunizations on 23 days. Vaccine rates were higher in those aged < or = 15 years (90%) than in adolescents and young adults (70%). Planned mop-up activities increased the coverage by 17%. The overall vaccine wastage was 11%. The cold chain was maintained and documented. 66 individuals reported of adverse events out of all vaccinees, where fever (21%), malaise (19%) and local redness (19%) were the major symptoms; no life-threatening event occurred. Three needle-sharp events were reported. CONCLUSION: The mass immunization proved feasible and safe, and vaccine coverage was high. Emphasis should be placed on: injection safety measures, community involvement and incorporation of mop-up strategies into any vaccination campaign. School-based and all-age Vi mass immunizations programs are potentially important public health strategies for prevention of typhoid fever in high-risk populations in southern China. SN - 1471-2458 UR - https://www.unboundmedicine.com/medline/citation/15904514/A_mass_vaccination_campaign_targeting_adults_and_children_to_prevent_typhoid_fever_in_Hechi L2 - https://bmcpublichealth.biomedcentral.com/articles/10.1186/1471-2458-5-49 DB - PRIME DP - Unbound Medicine ER -