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Antagonism of the nitric oxide synthase inhibitor, L-NAME, of the effects of phencyclidine on latent inhibition in taste aversion conditioning.
Behav Brain Res. 2005 Jun 03; 161(1):60-8.BB

Abstract

Latent inhibition (LI) is a behavioural procedure used to evaluate the potential propsychotic and antipsychotic properties of psychoactive drugs. In the present study, a conditioned taste aversion (CTA) procedure was used to investigate the effects of the nitric oxide (NO) synthase inhibitor, N(G)-nitro-L-arginine methyl ester (L-NAME), and the psychotomimetic drugs, phencyclidine (PCP) and d-amphetamine (d-AMP) on LI. PCP (2 mg/kg) and d-AMP (0.5 mg/kg) were both found to enhance LI in this procedure. The effect of d-AMP on LI was less pronounced and this drug also caused a weak disruption of taste aversion conditioning. Pretreatment with L-NAME (10 mg/kg) blocked the LI enhancing effect of PCP on LI but not that of d-AMP. L-NAME by itself caused an attenuation of LI. L-NAME has been shown to block also other behavioural and biochemical effects of PCP in previous studies and these results and the present findings suggest that at least some of the effects PCP are dependent on NO and possibly also that some NOS inhibitors may exert antipsychotic properties.

Authors+Show Affiliations

Department of Pharmacology, The Sahlgrenska Academy at Göteborg University, Göteborg University, P.O.B. 431, SE 405-30 Göteborg, Sweden.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15904710

Citation

Klamer, Daniel, et al. "Antagonism of the Nitric Oxide Synthase Inhibitor, L-NAME, of the Effects of Phencyclidine On Latent Inhibition in Taste Aversion Conditioning." Behavioural Brain Research, vol. 161, no. 1, 2005, pp. 60-8.
Klamer D, Pålsson E, Wass C, et al. Antagonism of the nitric oxide synthase inhibitor, L-NAME, of the effects of phencyclidine on latent inhibition in taste aversion conditioning. Behav Brain Res. 2005;161(1):60-8.
Klamer, D., Pålsson, E., Wass, C., Archer, T., Engel, J. A., & Svensson, L. (2005). Antagonism of the nitric oxide synthase inhibitor, L-NAME, of the effects of phencyclidine on latent inhibition in taste aversion conditioning. Behavioural Brain Research, 161(1), 60-8.
Klamer D, et al. Antagonism of the Nitric Oxide Synthase Inhibitor, L-NAME, of the Effects of Phencyclidine On Latent Inhibition in Taste Aversion Conditioning. Behav Brain Res. 2005 Jun 3;161(1):60-8. PubMed PMID: 15904710.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antagonism of the nitric oxide synthase inhibitor, L-NAME, of the effects of phencyclidine on latent inhibition in taste aversion conditioning. AU - Klamer,Daniel, AU - Pålsson,Erik, AU - Wass,Caroline, AU - Archer,Trevor, AU - Engel,Jörgen A, AU - Svensson,Lennart, Y1 - 2005/02/16/ PY - 2004/12/29/received PY - 2005/01/12/accepted PY - 2005/5/21/pubmed PY - 2005/7/30/medline PY - 2005/5/21/entrez SP - 60 EP - 8 JF - Behavioural brain research JO - Behav Brain Res VL - 161 IS - 1 N2 - Latent inhibition (LI) is a behavioural procedure used to evaluate the potential propsychotic and antipsychotic properties of psychoactive drugs. In the present study, a conditioned taste aversion (CTA) procedure was used to investigate the effects of the nitric oxide (NO) synthase inhibitor, N(G)-nitro-L-arginine methyl ester (L-NAME), and the psychotomimetic drugs, phencyclidine (PCP) and d-amphetamine (d-AMP) on LI. PCP (2 mg/kg) and d-AMP (0.5 mg/kg) were both found to enhance LI in this procedure. The effect of d-AMP on LI was less pronounced and this drug also caused a weak disruption of taste aversion conditioning. Pretreatment with L-NAME (10 mg/kg) blocked the LI enhancing effect of PCP on LI but not that of d-AMP. L-NAME by itself caused an attenuation of LI. L-NAME has been shown to block also other behavioural and biochemical effects of PCP in previous studies and these results and the present findings suggest that at least some of the effects PCP are dependent on NO and possibly also that some NOS inhibitors may exert antipsychotic properties. SN - 0166-4328 UR - https://www.unboundmedicine.com/medline/citation/15904710/Antagonism_of_the_nitric_oxide_synthase_inhibitor_L_NAME_of_the_effects_of_phencyclidine_on_latent_inhibition_in_taste_aversion_conditioning_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(05)00035-5 DB - PRIME DP - Unbound Medicine ER -