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Effects of 3,4-methylenedioxymethamphetamine and related amphetamines on autonomic and behavioral thermoregulation.
Pharmacol Biochem Behav 2005; 81(3):485-96PB

Abstract

3,4-Methylenedioxymethamphetamine (MDMA, 'ecstasy') and related amphetamines such as para-methoxyamphetamine (PMA) disrupt normal thermoregulation in humans and rats. Behavior, an important component of thermoregulation in mammals, has not been investigated with respect to these drugs. This is surprising as harm minimization depends on appropriate thermoregulatory behavior by drug users. The effects of MDMA (10 mg/kg), PMA (10 mg/kg) and d-amphetamine (2 mg/kg) were therefore studied in Sprague-Dawley rats, with telemetry implants measuring core body temperature (T(C)), locomotor activity and heart rate. Rats were administered an amphetamine or saline and confined to an ambient temperature of 21, 30 or 15 degrees C for 30 min, before being able to choose their preferred temperature (T(P)) on a thermally graded runway (11-41 degrees C). Confinement at 21 degrees C had little effect on T(C) in any group. At 30 degrees C MDMA and PMA increased T(C) compared to saline (p<0.001). MDMA treated animals behaviorally overcompensated for this effect (p<0.01). Locomotor activity after MDMA treatment was significantly elevated compared with saline (p<0.01). In contrast, at 15 degrees C MDMA administration resulted in a lower T(C) than saline (p<0.001). MDMA and PMA disrupt autonomic components of thermoregulation, while behavioral components are disrupted to a lesser extent. These results highlight differences in thermoregulatory responses to individual drugs, which were only evident when behavior was measured, and this may be important in assessing their risk.

Authors+Show Affiliations

Department of Clinical and Experimental Pharmacology, University of Adelaide, Adelaide, South Australia, 5005, Australia.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15904952

Citation

Jaehne, Emily J., et al. "Effects of 3,4-methylenedioxymethamphetamine and Related Amphetamines On Autonomic and Behavioral Thermoregulation." Pharmacology, Biochemistry, and Behavior, vol. 81, no. 3, 2005, pp. 485-96.
Jaehne EJ, Salem A, Irvine RJ. Effects of 3,4-methylenedioxymethamphetamine and related amphetamines on autonomic and behavioral thermoregulation. Pharmacol Biochem Behav. 2005;81(3):485-96.
Jaehne, E. J., Salem, A., & Irvine, R. J. (2005). Effects of 3,4-methylenedioxymethamphetamine and related amphetamines on autonomic and behavioral thermoregulation. Pharmacology, Biochemistry, and Behavior, 81(3), pp. 485-96.
Jaehne EJ, Salem A, Irvine RJ. Effects of 3,4-methylenedioxymethamphetamine and Related Amphetamines On Autonomic and Behavioral Thermoregulation. Pharmacol Biochem Behav. 2005;81(3):485-96. PubMed PMID: 15904952.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of 3,4-methylenedioxymethamphetamine and related amphetamines on autonomic and behavioral thermoregulation. AU - Jaehne,Emily J, AU - Salem,Abdallah, AU - Irvine,Rodney J, PY - 2004/12/02/received PY - 2005/04/18/revised PY - 2005/04/19/accepted PY - 2005/5/21/pubmed PY - 2005/9/27/medline PY - 2005/5/21/entrez SP - 485 EP - 96 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol. Biochem. Behav. VL - 81 IS - 3 N2 - 3,4-Methylenedioxymethamphetamine (MDMA, 'ecstasy') and related amphetamines such as para-methoxyamphetamine (PMA) disrupt normal thermoregulation in humans and rats. Behavior, an important component of thermoregulation in mammals, has not been investigated with respect to these drugs. This is surprising as harm minimization depends on appropriate thermoregulatory behavior by drug users. The effects of MDMA (10 mg/kg), PMA (10 mg/kg) and d-amphetamine (2 mg/kg) were therefore studied in Sprague-Dawley rats, with telemetry implants measuring core body temperature (T(C)), locomotor activity and heart rate. Rats were administered an amphetamine or saline and confined to an ambient temperature of 21, 30 or 15 degrees C for 30 min, before being able to choose their preferred temperature (T(P)) on a thermally graded runway (11-41 degrees C). Confinement at 21 degrees C had little effect on T(C) in any group. At 30 degrees C MDMA and PMA increased T(C) compared to saline (p<0.001). MDMA treated animals behaviorally overcompensated for this effect (p<0.01). Locomotor activity after MDMA treatment was significantly elevated compared with saline (p<0.01). In contrast, at 15 degrees C MDMA administration resulted in a lower T(C) than saline (p<0.001). MDMA and PMA disrupt autonomic components of thermoregulation, while behavioral components are disrupted to a lesser extent. These results highlight differences in thermoregulatory responses to individual drugs, which were only evident when behavior was measured, and this may be important in assessing their risk. SN - 0091-3057 UR - https://www.unboundmedicine.com/medline/citation/15904952/Effects_of_34_methylenedioxymethamphetamine_and_related_amphetamines_on_autonomic_and_behavioral_thermoregulation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-3057(05)00121-8 DB - PRIME DP - Unbound Medicine ER -