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Hippocampal metabolic abnormalities in mild cognitive impairment and Alzheimer's disease.
Neurosci Lett. 2005 Aug 12-19; 384(1-2):23-8.NL

Abstract

Mild cognitive impairment (MCI) defines a group of otherwise healthy elderly subjects with a markedly elevated risk of developing Alzheimer's disease (AD). In the search for biomarkers of MCI, we assessed whether MCI shares neurochemical abnormalities with AD in areas affected early in the course of the disease. As a secondary study aim, we tested to what extent neurochemical findings reflect neuropsychological deficits. Proton spectroscopy was performed in 19 MCI patients, 18 AD patients and 22 age and gender matched controls (CON) within the parietal gray and white matter (PWM and PGM) and the hippocampus (HIP). The cognitive test battery used included measures compiled by the Consortium to Establish a Registry for Alzheimer's Disease (CERAD). The N-acetyl-aspartate to creatine ratio (NAA/Cr) was significantly reduced in the HIP of MCI and AD compared with CON (p < 0.05). Only AD patients showed parietal abnormalities, namely significantly elevated myoinositol (mI/Cr and mI/NAA) in PGM, reduced NAA/Cr and elevated mI/NAA in PWM. MCI subjects were significantly impaired in categorical verbal fluency (VF) (p < 0.001) and delayed verbal recall (DVR) (p < 0.001). VF was positively correlated with hippocampal NAA/Cr (p < 0.05) and parietal mI/NAA (p < 0.05). In summary, this study demonstrates shared neurobiological hippocampal abnormalities in MCI and AD, whereas parietal lobe neurochemical profiles and functions were normal in MCI. Thus, biological evidence is provided that MCI represents a precursor stage of AD. Moreover, multivoxel 1H MRS may enable an objective staging of the neurodegenerative process underlying the age-dependent cognitive deficits eventually leading to dementia.

Authors+Show Affiliations

Department of Psychiatry, Memory Clinic, Max-Planck-Institute of Psychiatry, Kraepelinstrasse 2-10, 80802 Munich, Germany. ackl@mpipsykl.mpg.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15905028

Citation

Ackl, Nibal, et al. "Hippocampal Metabolic Abnormalities in Mild Cognitive Impairment and Alzheimer's Disease." Neuroscience Letters, vol. 384, no. 1-2, 2005, pp. 23-8.
Ackl N, Ising M, Schreiber YA, et al. Hippocampal metabolic abnormalities in mild cognitive impairment and Alzheimer's disease. Neurosci Lett. 2005;384(1-2):23-8.
Ackl, N., Ising, M., Schreiber, Y. A., Atiya, M., Sonntag, A., & Auer, D. P. (2005). Hippocampal metabolic abnormalities in mild cognitive impairment and Alzheimer's disease. Neuroscience Letters, 384(1-2), 23-8.
Ackl N, et al. Hippocampal Metabolic Abnormalities in Mild Cognitive Impairment and Alzheimer's Disease. Neurosci Lett. 2005 Aug 12-19;384(1-2):23-8. PubMed PMID: 15905028.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hippocampal metabolic abnormalities in mild cognitive impairment and Alzheimer's disease. AU - Ackl,Nibal, AU - Ising,Marcus, AU - Schreiber,Yvonne A, AU - Atiya,Monika, AU - Sonntag,Annette, AU - Auer,Dorothee P, PY - 2004/12/30/received PY - 2005/04/09/revised PY - 2005/04/13/accepted PY - 2005/5/21/pubmed PY - 2005/8/23/medline PY - 2005/5/21/entrez SP - 23 EP - 8 JF - Neuroscience letters JO - Neurosci. Lett. VL - 384 IS - 1-2 N2 - Mild cognitive impairment (MCI) defines a group of otherwise healthy elderly subjects with a markedly elevated risk of developing Alzheimer's disease (AD). In the search for biomarkers of MCI, we assessed whether MCI shares neurochemical abnormalities with AD in areas affected early in the course of the disease. As a secondary study aim, we tested to what extent neurochemical findings reflect neuropsychological deficits. Proton spectroscopy was performed in 19 MCI patients, 18 AD patients and 22 age and gender matched controls (CON) within the parietal gray and white matter (PWM and PGM) and the hippocampus (HIP). The cognitive test battery used included measures compiled by the Consortium to Establish a Registry for Alzheimer's Disease (CERAD). The N-acetyl-aspartate to creatine ratio (NAA/Cr) was significantly reduced in the HIP of MCI and AD compared with CON (p < 0.05). Only AD patients showed parietal abnormalities, namely significantly elevated myoinositol (mI/Cr and mI/NAA) in PGM, reduced NAA/Cr and elevated mI/NAA in PWM. MCI subjects were significantly impaired in categorical verbal fluency (VF) (p < 0.001) and delayed verbal recall (DVR) (p < 0.001). VF was positively correlated with hippocampal NAA/Cr (p < 0.05) and parietal mI/NAA (p < 0.05). In summary, this study demonstrates shared neurobiological hippocampal abnormalities in MCI and AD, whereas parietal lobe neurochemical profiles and functions were normal in MCI. Thus, biological evidence is provided that MCI represents a precursor stage of AD. Moreover, multivoxel 1H MRS may enable an objective staging of the neurodegenerative process underlying the age-dependent cognitive deficits eventually leading to dementia. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/15905028/Hippocampal_metabolic_abnormalities_in_mild_cognitive_impairment_and_Alzheimer's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(05)00433-7 DB - PRIME DP - Unbound Medicine ER -