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Performance of the automated and rapid STA Liatest D-dimer on the STA-R analyzer.
Thromb Res. 2005; 116(2):165-70.TR

Abstract

OBJECTIVE

The aim of the present study was to investigate the accuracy indices of the new automated and rapid microlatex D-dimer assay, STA Liatest D-Di, on the STA-R analyzer and to compare it with established D-dimer assays.

METHODS

D-dimer testing has been performed in 103 consecutive outpatients with suspected deep venous thrombosis (DVT). Diagnosis of DVT was established by contrast venography or color-coded duplex ultrasonography. D-dimers plasma concentrations were measured with the STA Liatest D-Di on the STA-R coagulation analyzer, with a reference ELISA technique (Asserachrom), with an automated quantitative latex-based immunoassay (Tinaquant) and with the VIDAS D-dimer test.

RESULTS

In total, 103 eligible outpatients entered the current study and DVT was detected in 46 patients (44.6%). Two duplicate D-dimer measurement with the STA Liatest D-Di revealed excellent correlation (r(S)=0.996) and almost identical sensitivity (each 98%), specificity (49% and 50%), negative predictive value (NPV; each 97%), positive predictive value (PPV; 61% and 62%) and exclusion rate (27% and 28%), respectively. Comparison of the STA Liatest D-Di with the other D-dimer tests revealed highly significant correlations (r(S)=0.951-0.979), highly comparable regression and excellent agreement in clinical interpretation of the test results (kappa coefficients 0.812-0.856). Moreover, sensitivity, specificity, NPV, PPV and exclusion rate at a cut-off level of 500 ng/ml were in the same range for the STA Liatest D-Di when compared with the other D-dimer tests.

CONCLUSION

The Liatest D-Di performed on the coagulation analyzer STA-R compares favorable with the VIDAS, Tinaquant and Asserachrom D-dimer tests and is suitable for the safe exclusion of DVT in symptomatic outpatients. The test can be included in an algorithm for DVT diagnosis including other diagnostic tools.

Authors+Show Affiliations

Division of Hematology and Central Hematology Laboratory, Kantonsspital Luzern, 6000 Luzern 16, Switzerland.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15907532

Citation

Waser, Gregor, et al. "Performance of the Automated and Rapid STA Liatest D-dimer On the STA-R Analyzer." Thrombosis Research, vol. 116, no. 2, 2005, pp. 165-70.
Waser G, Kathriner S, Wuillemin WA. Performance of the automated and rapid STA Liatest D-dimer on the STA-R analyzer. Thromb Res. 2005;116(2):165-70.
Waser, G., Kathriner, S., & Wuillemin, W. A. (2005). Performance of the automated and rapid STA Liatest D-dimer on the STA-R analyzer. Thrombosis Research, 116(2), 165-70.
Waser G, Kathriner S, Wuillemin WA. Performance of the Automated and Rapid STA Liatest D-dimer On the STA-R Analyzer. Thromb Res. 2005;116(2):165-70. PubMed PMID: 15907532.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Performance of the automated and rapid STA Liatest D-dimer on the STA-R analyzer. AU - Waser,Gregor, AU - Kathriner,Silvio, AU - Wuillemin,Walter A, Y1 - 2005/01/12/ PY - 2004/08/30/received PY - 2004/11/01/revised PY - 2004/12/01/accepted PY - 2005/5/24/pubmed PY - 2005/10/8/medline PY - 2005/5/24/entrez SP - 165 EP - 70 JF - Thrombosis research JO - Thromb Res VL - 116 IS - 2 N2 - OBJECTIVE: The aim of the present study was to investigate the accuracy indices of the new automated and rapid microlatex D-dimer assay, STA Liatest D-Di, on the STA-R analyzer and to compare it with established D-dimer assays. METHODS: D-dimer testing has been performed in 103 consecutive outpatients with suspected deep venous thrombosis (DVT). Diagnosis of DVT was established by contrast venography or color-coded duplex ultrasonography. D-dimers plasma concentrations were measured with the STA Liatest D-Di on the STA-R coagulation analyzer, with a reference ELISA technique (Asserachrom), with an automated quantitative latex-based immunoassay (Tinaquant) and with the VIDAS D-dimer test. RESULTS: In total, 103 eligible outpatients entered the current study and DVT was detected in 46 patients (44.6%). Two duplicate D-dimer measurement with the STA Liatest D-Di revealed excellent correlation (r(S)=0.996) and almost identical sensitivity (each 98%), specificity (49% and 50%), negative predictive value (NPV; each 97%), positive predictive value (PPV; 61% and 62%) and exclusion rate (27% and 28%), respectively. Comparison of the STA Liatest D-Di with the other D-dimer tests revealed highly significant correlations (r(S)=0.951-0.979), highly comparable regression and excellent agreement in clinical interpretation of the test results (kappa coefficients 0.812-0.856). Moreover, sensitivity, specificity, NPV, PPV and exclusion rate at a cut-off level of 500 ng/ml were in the same range for the STA Liatest D-Di when compared with the other D-dimer tests. CONCLUSION: The Liatest D-Di performed on the coagulation analyzer STA-R compares favorable with the VIDAS, Tinaquant and Asserachrom D-dimer tests and is suitable for the safe exclusion of DVT in symptomatic outpatients. The test can be included in an algorithm for DVT diagnosis including other diagnostic tools. SN - 0049-3848 UR - https://www.unboundmedicine.com/medline/citation/15907532/Performance_of_the_automated_and_rapid_STA_Liatest_D_dimer_on_the_STA_R_analyzer_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0049-3848(04)00633-4 DB - PRIME DP - Unbound Medicine ER -