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Antidermatophyte activity of ether extract of Nigella sativa and its active principle, thymoquinone.
J Ethnopharmacol. 2005 Oct 03; 101(1-3):116-9.JE

Abstract

The antifungal activity of ether extract of Nigella sativa seed and its active principle thymoquinone was tested against eight species of dermatophytes: four species of Trichophyton rubrum and one each of Trichophyton interdigitale, Trichophyton mentagrophytes, Epidermophyton floccosum and Microsporum canis. Agar diffusion method with serial dilutions of ether extract of Nigella sativa, thymoquinone and griseofulvin was employed. The incubation was carried out at 30 degrees C for 14 days. The diameter of fungal colonies and the percentage inhibition of the fungal growth at each dilution were determined, taking those of the controls as 100%. The minimum inhibitory concentration (MIC) was considered as the minimum concentration of the drug, which inhibited 80-100% of the fungal growth. The MICs of the ether extract of Nigella sativa and thymoquinone were between 10 and 40 and 0.125 and 0.25 mg/ml, respectively, while those of griseofulvin ranged from 0.00095 to 0.0155 mg/ml. These results denote the potentiality of Nigella sativa as a source for antidermatophyte drugs and support its use in folk medicine for the treatment of fungal skin infections.

Authors+Show Affiliations

Department of Dermatology, College of Medicine, King Faisal University, P.O. Box 10011, Dammam 31442, Saudi Arabia. saljabre@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15908151

Citation

Aljabre, Salih Hamad Mohamad, et al. "Antidermatophyte Activity of Ether Extract of Nigella Sativa and Its Active Principle, Thymoquinone." Journal of Ethnopharmacology, vol. 101, no. 1-3, 2005, pp. 116-9.
Aljabre SH, Randhawa MA, Akhtar N, et al. Antidermatophyte activity of ether extract of Nigella sativa and its active principle, thymoquinone. J Ethnopharmacol. 2005;101(1-3):116-9.
Aljabre, S. H., Randhawa, M. A., Akhtar, N., Alakloby, O. M., Alqurashi, A. M., & Aldossary, A. (2005). Antidermatophyte activity of ether extract of Nigella sativa and its active principle, thymoquinone. Journal of Ethnopharmacology, 101(1-3), 116-9.
Aljabre SH, et al. Antidermatophyte Activity of Ether Extract of Nigella Sativa and Its Active Principle, Thymoquinone. J Ethnopharmacol. 2005 Oct 3;101(1-3):116-9. PubMed PMID: 15908151.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antidermatophyte activity of ether extract of Nigella sativa and its active principle, thymoquinone. AU - Aljabre,Salih Hamad Mohamad, AU - Randhawa,Mohamad Akram, AU - Akhtar,Naeem, AU - Alakloby,Omar Mohamad, AU - Alqurashi,Abdulrahman Mohamad, AU - Aldossary,Ali, PY - 2005/01/17/received PY - 2005/03/12/revised PY - 2005/04/07/accepted PY - 2005/5/24/pubmed PY - 2005/12/29/medline PY - 2005/5/24/entrez SP - 116 EP - 9 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 101 IS - 1-3 N2 - The antifungal activity of ether extract of Nigella sativa seed and its active principle thymoquinone was tested against eight species of dermatophytes: four species of Trichophyton rubrum and one each of Trichophyton interdigitale, Trichophyton mentagrophytes, Epidermophyton floccosum and Microsporum canis. Agar diffusion method with serial dilutions of ether extract of Nigella sativa, thymoquinone and griseofulvin was employed. The incubation was carried out at 30 degrees C for 14 days. The diameter of fungal colonies and the percentage inhibition of the fungal growth at each dilution were determined, taking those of the controls as 100%. The minimum inhibitory concentration (MIC) was considered as the minimum concentration of the drug, which inhibited 80-100% of the fungal growth. The MICs of the ether extract of Nigella sativa and thymoquinone were between 10 and 40 and 0.125 and 0.25 mg/ml, respectively, while those of griseofulvin ranged from 0.00095 to 0.0155 mg/ml. These results denote the potentiality of Nigella sativa as a source for antidermatophyte drugs and support its use in folk medicine for the treatment of fungal skin infections. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/15908151/Antidermatophyte_activity_of_ether_extract_of_Nigella_sativa_and_its_active_principle_thymoquinone_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(05)00253-9 DB - PRIME DP - Unbound Medicine ER -