Tags

Type your tag names separated by a space and hit enter

High-dose corticosteroid therapy for bronchiolitis obliterans after bone marrow transplantation in children.
Bone Marrow Transplant 2005; 36(2):135-8BM

Abstract

Bronchiolitis obliterans (BO) is a rare but serious complication of paediatric allogenic bone marrow transplantation (BMT). Currently, there is no clear evidence that therapeutic interventions have a positive impact on the course of the disease. We here report our experience with high-dose pulse methylprednisolone therapy in children after BMT. Nine patients fulfilling clinical and radiologic signs of BO were included in this analysis. The total amount of treatment cycles with pulse methylprednisolone therapy ranged from 1 to 6 cycles (median four cycles). Oxygen saturation increased significantly with normalization of oxygen saturation at the end of therapy in all individuals. Normal oxygen saturation was maintained in all but one patient during follow-up (mean follow-up period 42 {plus/minus} 20 months, range 19-67 months). Forced expiratory volume in 1 s (FEV1) was within the normal range prior BMT and significantly diminished at the time of BO diagnosis. Treatment led to stabilization of lung function, with a significant improvement of FEV1 after 2 months. In all, 7/9 patients remained in clinically stable condition without further deterioration of lung function during follow-up. These data would suggest that anti-inflammatory therapy may be a valuable treatment option in paediatric patients with bronchiolitis obliterans after BMT.

Authors+Show Affiliations

Department of Paediatrics, Children's Hospital, University of Essen, Essen, Germany. f.ratjen@uni-essen.deNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15908967

Citation

Ratjen, F, et al. "High-dose Corticosteroid Therapy for Bronchiolitis Obliterans After Bone Marrow Transplantation in Children." Bone Marrow Transplantation, vol. 36, no. 2, 2005, pp. 135-8.
Ratjen F, Rjabko O, Kremens B. High-dose corticosteroid therapy for bronchiolitis obliterans after bone marrow transplantation in children. Bone Marrow Transplant. 2005;36(2):135-8.
Ratjen, F., Rjabko, O., & Kremens, B. (2005). High-dose corticosteroid therapy for bronchiolitis obliterans after bone marrow transplantation in children. Bone Marrow Transplantation, 36(2), pp. 135-8.
Ratjen F, Rjabko O, Kremens B. High-dose Corticosteroid Therapy for Bronchiolitis Obliterans After Bone Marrow Transplantation in Children. Bone Marrow Transplant. 2005;36(2):135-8. PubMed PMID: 15908967.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High-dose corticosteroid therapy for bronchiolitis obliterans after bone marrow transplantation in children. AU - Ratjen,F, AU - Rjabko,O, AU - Kremens,B, PY - 2005/5/24/pubmed PY - 2005/9/24/medline PY - 2005/5/24/entrez SP - 135 EP - 8 JF - Bone marrow transplantation JO - Bone Marrow Transplant. VL - 36 IS - 2 N2 - Bronchiolitis obliterans (BO) is a rare but serious complication of paediatric allogenic bone marrow transplantation (BMT). Currently, there is no clear evidence that therapeutic interventions have a positive impact on the course of the disease. We here report our experience with high-dose pulse methylprednisolone therapy in children after BMT. Nine patients fulfilling clinical and radiologic signs of BO were included in this analysis. The total amount of treatment cycles with pulse methylprednisolone therapy ranged from 1 to 6 cycles (median four cycles). Oxygen saturation increased significantly with normalization of oxygen saturation at the end of therapy in all individuals. Normal oxygen saturation was maintained in all but one patient during follow-up (mean follow-up period 42 {plus/minus} 20 months, range 19-67 months). Forced expiratory volume in 1 s (FEV1) was within the normal range prior BMT and significantly diminished at the time of BO diagnosis. Treatment led to stabilization of lung function, with a significant improvement of FEV1 after 2 months. In all, 7/9 patients remained in clinically stable condition without further deterioration of lung function during follow-up. These data would suggest that anti-inflammatory therapy may be a valuable treatment option in paediatric patients with bronchiolitis obliterans after BMT. SN - 0268-3369 UR - https://www.unboundmedicine.com/medline/citation/15908967/High_dose_corticosteroid_therapy_for_bronchiolitis_obliterans_after_bone_marrow_transplantation_in_children_ L2 - http://dx.doi.org/10.1038/sj.bmt.1705026 DB - PRIME DP - Unbound Medicine ER -