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[Uric acid--more deleterious than we thought?].
Tidsskr Nor Laegeforen. 2005 May 19; 125(10):1330-2.TN

Abstract

BACKGROUND

Hyperuricaemia is associated with reduced renal function and increased cardiovascular risk. It is still disputed, however, whether hyperuricaemia is an independent cardiovascular risk factor or just a marker of increased cardiovascular risk.

MATERIAL AND METHODS

A review of the literature based on Medline is presented and data from the LIFE (Losartan Intervention For Endpoint reduction in hypertension) study discussed in relation to the association between uric acid and cardiovascular events.

RESULTS

Epidemiological data have shown an independent relationship between serum uric acid and cardiovascular risk, at least in women. In LIFE, uric acid at baseline corresponded positively with cardiovascular risk in women, though not in men. Differences in serum uric acid during the study could statistically explain 29% of the reduction in cardiovascular events in the losartan group compared to atenolol.

INTERPRETATION

These findings support the hypothesis that uric acid is an independent cardiovascular risk factor. Further studies are warranted.

Links

Publisher Full Text

Authors+Show Affiliations

Høieggen A
Nyremedisinsk avdeling, Medisinsk divisjon, Ullevål universitetsykehus, 0407 Oslo. aud.hoieggen@ ulleval.no
Os I
No affiliation info available
Kjeldsen SE
No affiliation info available

MeSH

Angiotensin II Type 1 Receptor BlockersAntihypertensive AgentsCardiovascular DiseasesFemaleHumansHyperuricemiaKidneyLosartanMaleRandomized Controlled Trials as TopicRisk FactorsSex FactorsUric Acid

Pub Type(s)

English Abstract
Journal Article
Review

Language

nor

PubMed ID

15909004

Citation

Høieggen, Aud, et al. "[Uric Acid--more Deleterious Than We Thought?]." Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke, vol. 125, no. 10, 2005, pp. 1330-2.
Høieggen A, Os I, Kjeldsen SE. [Uric acid--more deleterious than we thought?]. Tidsskr Nor Laegeforen. 2005;125(10):1330-2.
Høieggen, A., Os, I., & Kjeldsen, S. E. (2005). [Uric acid--more deleterious than we thought?]. Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke, 125(10), 1330-2.
Høieggen A, Os I, Kjeldsen SE. [Uric Acid--more Deleterious Than We Thought?]. Tidsskr Nor Laegeforen. 2005 May 19;125(10):1330-2. PubMed PMID: 15909004.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Uric acid--more deleterious than we thought?]. AU - Høieggen,Aud, AU - Os,Ingrid, AU - Kjeldsen,Sverre E, PY - 2005/5/24/pubmed PY - 2005/6/9/medline PY - 2005/5/24/entrez SP - 1330 EP - 2 JF - Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke JO - Tidsskr Nor Laegeforen VL - 125 IS - 10 N2 - BACKGROUND: Hyperuricaemia is associated with reduced renal function and increased cardiovascular risk. It is still disputed, however, whether hyperuricaemia is an independent cardiovascular risk factor or just a marker of increased cardiovascular risk. MATERIAL AND METHODS: A review of the literature based on Medline is presented and data from the LIFE (Losartan Intervention For Endpoint reduction in hypertension) study discussed in relation to the association between uric acid and cardiovascular events. RESULTS: Epidemiological data have shown an independent relationship between serum uric acid and cardiovascular risk, at least in women. In LIFE, uric acid at baseline corresponded positively with cardiovascular risk in women, though not in men. Differences in serum uric acid during the study could statistically explain 29% of the reduction in cardiovascular events in the losartan group compared to atenolol. INTERPRETATION: These findings support the hypothesis that uric acid is an independent cardiovascular risk factor. Further studies are warranted. SN - 0807-7096 UR - https://www.unboundmedicine.com/medline/citation/15909004/[Uric_acid__more_deleterious_than_we_thought]_ L2 - http://tidsskriftet.no/article/1190504 DB - PRIME DP - Unbound Medicine ER -