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Synthesis, properties and controlled release behaviors of hydrogel networks using cyclodextrin as pendant groups.

Abstract

Based on inclusion character of beta-cyclodextrin (beta-CD) with drug molecule and low glass transition temperature of poly(2-hydroxyethyl acrylate) (PHEA), a series of hydrogels with different compositions were synthesized by the copolymerization of a monovinyl cyclodexrin monomer with 2-hydroxyethyl acrylate (HEA). The structure and properties of the hydrogels were characterized by FTIR, DSC, TGA and swelling measurements. It is found that swelling ratios of these beta-CD hydrogels can keep a relative stability in the range of pH from 1.4 to 7.4, and are not sensitive to change in NaCl concentration. Using drug N-acety-5-methoxytryptamine (melatonin, MEL) as a model molecule, the controlled drug release behaviors of these hydrogels were investigated. The results indicate that the diffusion and permeation of MEL from the hydrogels may be a dominant factor for its release. Owing to the formation of MEL/beta-CD retarding diffusion rate of MEL, a sustained release of MEL from hydrogel with high content of beta-CD can be obtained compared with hydrogel PHEA without beta-CD.

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  • Publisher Full Text
  • Authors

    ,

    Source

    Biomaterials 26:32 2005 Nov pg 6367-74

    MeSH

    Absorption
    Acrylates
    Cyclodextrins
    Delayed-Action Preparations
    Diffusion
    Hydrogels
    Hydrogen-Ion Concentration
    Materials Testing
    Melatonin
    Molecular Conformation

    Pub Type(s)

    Comparative Study
    Evaluation Studies
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    15913774

    Citation

    TY - JOUR T1 - Synthesis, properties and controlled release behaviors of hydrogel networks using cyclodextrin as pendant groups. AU - Liu,Yu-Yang, AU - Fan,Xiao-Dong, PY - 2005/1/30/received PY - 2005/4/4/accepted PY - 2005/5/26/pubmed PY - 2005/12/13/medline PY - 2005/5/26/entrez SP - 6367 EP - 74 JF - Biomaterials JO - Biomaterials VL - 26 IS - 32 N2 - Based on inclusion character of beta-cyclodextrin (beta-CD) with drug molecule and low glass transition temperature of poly(2-hydroxyethyl acrylate) (PHEA), a series of hydrogels with different compositions were synthesized by the copolymerization of a monovinyl cyclodexrin monomer with 2-hydroxyethyl acrylate (HEA). The structure and properties of the hydrogels were characterized by FTIR, DSC, TGA and swelling measurements. It is found that swelling ratios of these beta-CD hydrogels can keep a relative stability in the range of pH from 1.4 to 7.4, and are not sensitive to change in NaCl concentration. Using drug N-acety-5-methoxytryptamine (melatonin, MEL) as a model molecule, the controlled drug release behaviors of these hydrogels were investigated. The results indicate that the diffusion and permeation of MEL from the hydrogels may be a dominant factor for its release. Owing to the formation of MEL/beta-CD retarding diffusion rate of MEL, a sustained release of MEL from hydrogel with high content of beta-CD can be obtained compared with hydrogel PHEA without beta-CD. SN - 0142-9612 UR - https://www.unboundmedicine.com/medline/citation/15913774/Synthesis_properties_and_controlled_release_behaviors_of_hydrogel_networks_using_cyclodextrin_as_pendant_groups_ L2 - http://linkinghub.elsevier.com/retrieve/pii/S0142-9612(05)00317-0 ER -