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Involvement of the ventral tegmental area (VTA) in morphine-induced memory retention in morphine-sensitized rats.
Behav Brain Res. 2005 Aug 30; 163(1):100-6.BB

Abstract

In the present study, the effects of intra-ventral tegmental area (VTA) injections of morphine on memory retention of a one-trial passive avoidance task have been investigated in morphine-sensitized rats. Retrieval was examined 24h after training and used as memory retention. Sensitization was obtained by subcutaneous (s.c.) injections of morphine, once daily for 3 and 5 days free of the opioid before training. Post-training administration of the both systemic (2.5, 5 and 7.5mg/kg, s.c.) and intra-VTA (5 and 7.5microg/rat) of morphine, dose-dependently decreased memory retention. The response induced by post-training administration of intra-VTA morphine (7.5microg/rat) was significantly reversed in morphine-sensitized rats. The inhibition of morphine-induced amnesia in morphine-sensitized rats was decreased by once daily injections of naloxone (0.5, 1 and 2mg/kg, s.c.), SCH 23390 (0.025, 0.05 and 0.1mg/kg, s.c.) or sulpiride (25, 50 and 100mg/kg, s.c.), during the sensitization. The results suggest that VTA has an important role in morphine-induced amnesia and morphine sensitization affects this process through opioid and dopamine receptors.

Authors+Show Affiliations

Department of Pharmacology and Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, P.O. Box 13145-784, Tehran, Iran. zarinmr@ams.ac.irNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15913802

Citation

Zarrindast, Mohammad-Reza, et al. "Involvement of the Ventral Tegmental Area (VTA) in Morphine-induced Memory Retention in Morphine-sensitized Rats." Behavioural Brain Research, vol. 163, no. 1, 2005, pp. 100-6.
Zarrindast MR, Farajzadeh Z, Rostami P, et al. Involvement of the ventral tegmental area (VTA) in morphine-induced memory retention in morphine-sensitized rats. Behav Brain Res. 2005;163(1):100-6.
Zarrindast, M. R., Farajzadeh, Z., Rostami, P., Rezayof, A., & Nourjah, P. (2005). Involvement of the ventral tegmental area (VTA) in morphine-induced memory retention in morphine-sensitized rats. Behavioural Brain Research, 163(1), 100-6.
Zarrindast MR, et al. Involvement of the Ventral Tegmental Area (VTA) in Morphine-induced Memory Retention in Morphine-sensitized Rats. Behav Brain Res. 2005 Aug 30;163(1):100-6. PubMed PMID: 15913802.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Involvement of the ventral tegmental area (VTA) in morphine-induced memory retention in morphine-sensitized rats. AU - Zarrindast,Mohammad-Reza, AU - Farajzadeh,Zahra, AU - Rostami,Parvin, AU - Rezayof,Ameneh, AU - Nourjah,Parvaneh, PY - 2005/03/08/received PY - 2005/04/18/revised PY - 2005/04/18/accepted PY - 2005/5/26/pubmed PY - 2005/12/13/medline PY - 2005/5/26/entrez SP - 100 EP - 6 JF - Behavioural brain research JO - Behav Brain Res VL - 163 IS - 1 N2 - In the present study, the effects of intra-ventral tegmental area (VTA) injections of morphine on memory retention of a one-trial passive avoidance task have been investigated in morphine-sensitized rats. Retrieval was examined 24h after training and used as memory retention. Sensitization was obtained by subcutaneous (s.c.) injections of morphine, once daily for 3 and 5 days free of the opioid before training. Post-training administration of the both systemic (2.5, 5 and 7.5mg/kg, s.c.) and intra-VTA (5 and 7.5microg/rat) of morphine, dose-dependently decreased memory retention. The response induced by post-training administration of intra-VTA morphine (7.5microg/rat) was significantly reversed in morphine-sensitized rats. The inhibition of morphine-induced amnesia in morphine-sensitized rats was decreased by once daily injections of naloxone (0.5, 1 and 2mg/kg, s.c.), SCH 23390 (0.025, 0.05 and 0.1mg/kg, s.c.) or sulpiride (25, 50 and 100mg/kg, s.c.), during the sensitization. The results suggest that VTA has an important role in morphine-induced amnesia and morphine sensitization affects this process through opioid and dopamine receptors. SN - 0166-4328 UR - https://www.unboundmedicine.com/medline/citation/15913802/Involvement_of_the_ventral_tegmental_area__VTA__in_morphine_induced_memory_retention_in_morphine_sensitized_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(05)00163-4 DB - PRIME DP - Unbound Medicine ER -