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Synthesis of (1,4)-naphthoquinono-[3,2-c]-1H-pyrazoles and their (1,4)-naphthohydroquinone derivatives as antifungal, antibacterial, and anticancer agents.
Bioorg Med Chem Lett. 2005 Jul 01; 15(13):3288-91.BM

Abstract

A series of (1,4)-naphthoquinono [3,2-c]-1H-pyrazoles and their (1,4)-naphthohydroquinone derivatives 2-7 were synthesized and evaluated for antifungal, antibacterial, and anticancer activities. The structure-activity relationship of these compounds was studied and the results show that the compound 2b exhibited in vitro antifungal activity against Candida albicans and Cryptococcus neoformans, and also possessed antibacterial profile against Klebsiella pneumoniae and Escherichia coli whereas 1c showed anticancer activity against Walker 256 Carcinosarcoma in rats.

Authors+Show Affiliations

Department of Chemistry, Lucknow University, Lucknow 226007, India. vishnutandon@yahoo.co.inNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15913995

Citation

Tandon, Vishnu K., et al. "Synthesis of (1,4)-naphthoquinono-[3,2-c]-1H-pyrazoles and Their (1,4)-naphthohydroquinone Derivatives as Antifungal, Antibacterial, and Anticancer Agents." Bioorganic & Medicinal Chemistry Letters, vol. 15, no. 13, 2005, pp. 3288-91.
Tandon VK, Yadav DB, Chaturvedi AK, et al. Synthesis of (1,4)-naphthoquinono-[3,2-c]-1H-pyrazoles and their (1,4)-naphthohydroquinone derivatives as antifungal, antibacterial, and anticancer agents. Bioorg Med Chem Lett. 2005;15(13):3288-91.
Tandon, V. K., Yadav, D. B., Chaturvedi, A. K., & Shukla, P. K. (2005). Synthesis of (1,4)-naphthoquinono-[3,2-c]-1H-pyrazoles and their (1,4)-naphthohydroquinone derivatives as antifungal, antibacterial, and anticancer agents. Bioorganic & Medicinal Chemistry Letters, 15(13), 3288-91.
Tandon VK, et al. Synthesis of (1,4)-naphthoquinono-[3,2-c]-1H-pyrazoles and Their (1,4)-naphthohydroquinone Derivatives as Antifungal, Antibacterial, and Anticancer Agents. Bioorg Med Chem Lett. 2005 Jul 1;15(13):3288-91. PubMed PMID: 15913995.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synthesis of (1,4)-naphthoquinono-[3,2-c]-1H-pyrazoles and their (1,4)-naphthohydroquinone derivatives as antifungal, antibacterial, and anticancer agents. AU - Tandon,Vishnu K, AU - Yadav,Dharmendra B, AU - Chaturvedi,Ashok K, AU - Shukla,Praveen K, PY - 2005/03/01/received PY - 2005/04/21/accepted PY - 2005/5/26/pubmed PY - 2005/10/12/medline PY - 2005/5/26/entrez SP - 3288 EP - 91 JF - Bioorganic & medicinal chemistry letters JO - Bioorg. Med. Chem. Lett. VL - 15 IS - 13 N2 - A series of (1,4)-naphthoquinono [3,2-c]-1H-pyrazoles and their (1,4)-naphthohydroquinone derivatives 2-7 were synthesized and evaluated for antifungal, antibacterial, and anticancer activities. The structure-activity relationship of these compounds was studied and the results show that the compound 2b exhibited in vitro antifungal activity against Candida albicans and Cryptococcus neoformans, and also possessed antibacterial profile against Klebsiella pneumoniae and Escherichia coli whereas 1c showed anticancer activity against Walker 256 Carcinosarcoma in rats. SN - 0960-894X UR - https://www.unboundmedicine.com/medline/citation/15913995/Synthesis_of__14__naphthoquinono_[32_c]_1H_pyrazoles_and_their__14__naphthohydroquinone_derivatives_as_antifungal_antibacterial_and_anticancer_agents_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0960-894X(05)00542-1 DB - PRIME DP - Unbound Medicine ER -