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Effects of two combined oral contraceptives containing ethinyl estradiol 20 microg combined with either drospirenone or desogestrel on lipids, hemostatic parameters and carbohydrate metabolism.
Contraception. 2005 Jun; 71(6):409-16.C

Abstract

OBJECTIVE

To compare the effect of ethinyl estradiol 20 microg/drospirenone 3 mg (EE 20 microg/DRSP 3 mg) administered according to a 24/4 regimen with ethinyl estradiol 20 microg/desogestrel 150 microg (EE 20 microg/DSG 150 microg) administered according to the conventional 21/7 regimen on lipid, carbohydrate and hemostatic parameters.

STUDY DESIGN

In this open-label study, healthy women were randomized to EE 20 microg/DRSP 3 mg or EE 20 microg/DSG 150 microg for seven cycles. Mean differences in high-density lipoprotein (HDL)- and low-density lipoprotein (LDL)-cholesterol levels at cycle 7 compared to baseline were assessed. Secondary variables included changes in other lipid, hemostatic and carbohydrate parameters.

RESULTS

Both treatments increased HDL-cholesterol, but decreased LDL-cholesterol by a comparable extent. Although slightly elevated in both groups, blood glucose and C-peptide levels measured during oral glucose tolerance tests were within normal reference ranges at cycle 7. Overall, the differences in lipid, hemostatic or carbohydrate parameters were not significant between the two treatments.

CONCLUSION

EE 20 microg/DRSP 3 mg has a good safety profile comparable with EE 20 microg/DSG 150 microg.

Authors+Show Affiliations

Dinox Medical Investigations, Groenewoudseweg 317, NL-6524 TX, Nijmegen, The Netherlands.No affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15914128

Citation

Klipping, Christine, and Joachim Marr. "Effects of Two Combined Oral Contraceptives Containing Ethinyl Estradiol 20 Microg Combined With Either Drospirenone or Desogestrel On Lipids, Hemostatic Parameters and Carbohydrate Metabolism." Contraception, vol. 71, no. 6, 2005, pp. 409-16.
Klipping C, Marr J. Effects of two combined oral contraceptives containing ethinyl estradiol 20 microg combined with either drospirenone or desogestrel on lipids, hemostatic parameters and carbohydrate metabolism. Contraception. 2005;71(6):409-16.
Klipping, C., & Marr, J. (2005). Effects of two combined oral contraceptives containing ethinyl estradiol 20 microg combined with either drospirenone or desogestrel on lipids, hemostatic parameters and carbohydrate metabolism. Contraception, 71(6), 409-16.
Klipping C, Marr J. Effects of Two Combined Oral Contraceptives Containing Ethinyl Estradiol 20 Microg Combined With Either Drospirenone or Desogestrel On Lipids, Hemostatic Parameters and Carbohydrate Metabolism. Contraception. 2005;71(6):409-16. PubMed PMID: 15914128.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of two combined oral contraceptives containing ethinyl estradiol 20 microg combined with either drospirenone or desogestrel on lipids, hemostatic parameters and carbohydrate metabolism. AU - Klipping,Christine, AU - Marr,Joachim, PY - 2004/09/24/received PY - 2004/11/10/revised PY - 2004/12/07/accepted PY - 2005/5/26/pubmed PY - 2006/1/13/medline PY - 2005/5/26/entrez SP - 409 EP - 16 JF - Contraception JO - Contraception VL - 71 IS - 6 N2 - OBJECTIVE: To compare the effect of ethinyl estradiol 20 microg/drospirenone 3 mg (EE 20 microg/DRSP 3 mg) administered according to a 24/4 regimen with ethinyl estradiol 20 microg/desogestrel 150 microg (EE 20 microg/DSG 150 microg) administered according to the conventional 21/7 regimen on lipid, carbohydrate and hemostatic parameters. STUDY DESIGN: In this open-label study, healthy women were randomized to EE 20 microg/DRSP 3 mg or EE 20 microg/DSG 150 microg for seven cycles. Mean differences in high-density lipoprotein (HDL)- and low-density lipoprotein (LDL)-cholesterol levels at cycle 7 compared to baseline were assessed. Secondary variables included changes in other lipid, hemostatic and carbohydrate parameters. RESULTS: Both treatments increased HDL-cholesterol, but decreased LDL-cholesterol by a comparable extent. Although slightly elevated in both groups, blood glucose and C-peptide levels measured during oral glucose tolerance tests were within normal reference ranges at cycle 7. Overall, the differences in lipid, hemostatic or carbohydrate parameters were not significant between the two treatments. CONCLUSION: EE 20 microg/DRSP 3 mg has a good safety profile comparable with EE 20 microg/DSG 150 microg. SN - 0010-7824 UR - https://www.unboundmedicine.com/medline/citation/15914128/Effects_of_two_combined_oral_contraceptives_containing_ethinyl_estradiol_20_microg_combined_with_either_drospirenone_or_desogestrel_on_lipids_hemostatic_parameters_and_carbohydrate_metabolism_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0010-7824(05)00019-3 DB - PRIME DP - Unbound Medicine ER -