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Dietary conjugated linoleic acid reduces lipid peroxidation by increasing oxidative stability in rats.
J Nutr Sci Vitaminol (Tokyo). 2005 Feb; 51(1):8-15.JN

Abstract

The antioxidative effect of conjugated linoleic acid (CLA) was examined by determining lipid peroxidation and antioxidative enzyme activities. Male Sprague-Dawley rats were fed one of the experimental diets-normal diet, vitamin E-deficient control diet, 0.5% CLA vitamin E-deficient diet, or 1.5% CLA vitamin E-deficient diet for 5 wk. Hepatic thiobarbituric acid reactive substances (TBARS) were increased in the vitamin E-deficient control group, but they were was significantly lowered in the CLA groups. Similarly, hepatic glutathione peroxidase activity was increased in the vitamin E-deficient diet and reduced by CLA supplementation. In addition, CLA caused a significant decrease in superoxide dismutase activity while having no effect on catalase activity. Analyses of the fatty acid composition revealed that dietary CLA was incorporated into hepatic microsomal membrane dose-dependently. Compared to the vitamin E-deficient control, CLA resulted in significantly higher saturated and monounsaturated fatty acids (palmitic and oleic acids) while lowering levels of oxidation-susceptible polyunsaturated fatty acids (linoleic, linolenic, and arachidonic acids) in both plasma and hepatic membrane. The concentrations of plasma cholesterol and triacylglycerol (TG) were lower in the 1.5% CLA group than in other groups. These results suggest that dietary CLA has antiatherosclerotic and antioxidant activity by increasing oxidative stability in plasma and hepatic membrane in the vitamin E-deficient rats.

Authors+Show Affiliations

Food Function Research Division, Korea Food Research Institute, Seongnam 463-746, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15915662

Citation

Kim, Hye-Kyeong, et al. "Dietary Conjugated Linoleic Acid Reduces Lipid Peroxidation By Increasing Oxidative Stability in Rats." Journal of Nutritional Science and Vitaminology, vol. 51, no. 1, 2005, pp. 8-15.
Kim HK, Kim SR, Ahn JY, et al. Dietary conjugated linoleic acid reduces lipid peroxidation by increasing oxidative stability in rats. J Nutr Sci Vitaminol (Tokyo). 2005;51(1):8-15.
Kim, H. K., Kim, S. R., Ahn, J. Y., Cho, I. J., Yoon, C. S., & Ha, T. Y. (2005). Dietary conjugated linoleic acid reduces lipid peroxidation by increasing oxidative stability in rats. Journal of Nutritional Science and Vitaminology, 51(1), 8-15.
Kim HK, et al. Dietary Conjugated Linoleic Acid Reduces Lipid Peroxidation By Increasing Oxidative Stability in Rats. J Nutr Sci Vitaminol (Tokyo). 2005;51(1):8-15. PubMed PMID: 15915662.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary conjugated linoleic acid reduces lipid peroxidation by increasing oxidative stability in rats. AU - Kim,Hye-Kyeong, AU - Kim,Sung-Ran, AU - Ahn,Ji-Yoon, AU - Cho,Il-Jin, AU - Yoon,Chil-Suk, AU - Ha,Tae-Youl, PY - 2005/5/27/pubmed PY - 2005/7/23/medline PY - 2005/5/27/entrez SP - 8 EP - 15 JF - Journal of nutritional science and vitaminology JO - J Nutr Sci Vitaminol (Tokyo) VL - 51 IS - 1 N2 - The antioxidative effect of conjugated linoleic acid (CLA) was examined by determining lipid peroxidation and antioxidative enzyme activities. Male Sprague-Dawley rats were fed one of the experimental diets-normal diet, vitamin E-deficient control diet, 0.5% CLA vitamin E-deficient diet, or 1.5% CLA vitamin E-deficient diet for 5 wk. Hepatic thiobarbituric acid reactive substances (TBARS) were increased in the vitamin E-deficient control group, but they were was significantly lowered in the CLA groups. Similarly, hepatic glutathione peroxidase activity was increased in the vitamin E-deficient diet and reduced by CLA supplementation. In addition, CLA caused a significant decrease in superoxide dismutase activity while having no effect on catalase activity. Analyses of the fatty acid composition revealed that dietary CLA was incorporated into hepatic microsomal membrane dose-dependently. Compared to the vitamin E-deficient control, CLA resulted in significantly higher saturated and monounsaturated fatty acids (palmitic and oleic acids) while lowering levels of oxidation-susceptible polyunsaturated fatty acids (linoleic, linolenic, and arachidonic acids) in both plasma and hepatic membrane. The concentrations of plasma cholesterol and triacylglycerol (TG) were lower in the 1.5% CLA group than in other groups. These results suggest that dietary CLA has antiatherosclerotic and antioxidant activity by increasing oxidative stability in plasma and hepatic membrane in the vitamin E-deficient rats. SN - 0301-4800 UR - https://www.unboundmedicine.com/medline/citation/15915662/Dietary_conjugated_linoleic_acid_reduces_lipid_peroxidation_by_increasing_oxidative_stability_in_rats_ L2 - https://medlineplus.gov/antioxidants.html DB - PRIME DP - Unbound Medicine ER -