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Dietary conjugated linoleic acid reduces lipid peroxidation by increasing oxidative stability in rats.
J Nutr Sci Vitaminol (Tokyo). 2005 Feb; 51(1):8-15.JN

Abstract

The antioxidative effect of conjugated linoleic acid (CLA) was examined by determining lipid peroxidation and antioxidative enzyme activities. Male Sprague-Dawley rats were fed one of the experimental diets-normal diet, vitamin E-deficient control diet, 0.5% CLA vitamin E-deficient diet, or 1.5% CLA vitamin E-deficient diet for 5 wk. Hepatic thiobarbituric acid reactive substances (TBARS) were increased in the vitamin E-deficient control group, but they were was significantly lowered in the CLA groups. Similarly, hepatic glutathione peroxidase activity was increased in the vitamin E-deficient diet and reduced by CLA supplementation. In addition, CLA caused a significant decrease in superoxide dismutase activity while having no effect on catalase activity. Analyses of the fatty acid composition revealed that dietary CLA was incorporated into hepatic microsomal membrane dose-dependently. Compared to the vitamin E-deficient control, CLA resulted in significantly higher saturated and monounsaturated fatty acids (palmitic and oleic acids) while lowering levels of oxidation-susceptible polyunsaturated fatty acids (linoleic, linolenic, and arachidonic acids) in both plasma and hepatic membrane. The concentrations of plasma cholesterol and triacylglycerol (TG) were lower in the 1.5% CLA group than in other groups. These results suggest that dietary CLA has antiatherosclerotic and antioxidant activity by increasing oxidative stability in plasma and hepatic membrane in the vitamin E-deficient rats.

Authors+Show Affiliations

Kim HK
Food Function Research Division, Korea Food Research Institute, Seongnam 463-746, Korea.
Kim SR
No affiliation info available
Ahn JY
No affiliation info available
Cho IJ
No affiliation info available
Yoon CS
No affiliation info available
Ha TY
No affiliation info available

MeSH

Alanine TransaminaseAnimalsAntioxidantsAspartate AminotransferasesCell MembraneDietDietary Fats, UnsaturatedFatty AcidsGlutathione PeroxidaseLinoleic Acids, ConjugatedLipid PeroxidationLipidsLiverMaleMicrosomes, LiverOxidation-ReductionRatsRats, Sprague-DawleySuperoxide DismutaseThiobarbituric Acid Reactive SubstancesVitamin E

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15915662

Citation

Kim, Hye-Kyeong, et al. "Dietary Conjugated Linoleic Acid Reduces Lipid Peroxidation By Increasing Oxidative Stability in Rats." Journal of Nutritional Science and Vitaminology, vol. 51, no. 1, 2005, pp. 8-15.
Kim HK, Kim SR, Ahn JY, et al. Dietary conjugated linoleic acid reduces lipid peroxidation by increasing oxidative stability in rats. J Nutr Sci Vitaminol (Tokyo). 2005;51(1):8-15.
Kim, H. K., Kim, S. R., Ahn, J. Y., Cho, I. J., Yoon, C. S., & Ha, T. Y. (2005). Dietary conjugated linoleic acid reduces lipid peroxidation by increasing oxidative stability in rats. Journal of Nutritional Science and Vitaminology, 51(1), 8-15.
Kim HK, et al. Dietary Conjugated Linoleic Acid Reduces Lipid Peroxidation By Increasing Oxidative Stability in Rats. J Nutr Sci Vitaminol (Tokyo). 2005;51(1):8-15. PubMed PMID: 15915662.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary conjugated linoleic acid reduces lipid peroxidation by increasing oxidative stability in rats. AU - Kim,Hye-Kyeong, AU - Kim,Sung-Ran, AU - Ahn,Ji-Yoon, AU - Cho,Il-Jin, AU - Yoon,Chil-Suk, AU - Ha,Tae-Youl, PY - 2005/5/27/pubmed PY - 2005/7/23/medline PY - 2005/5/27/entrez SP - 8 EP - 15 JF - Journal of nutritional science and vitaminology JO - J Nutr Sci Vitaminol (Tokyo) VL - 51 IS - 1 N2 - The antioxidative effect of conjugated linoleic acid (CLA) was examined by determining lipid peroxidation and antioxidative enzyme activities. Male Sprague-Dawley rats were fed one of the experimental diets-normal diet, vitamin E-deficient control diet, 0.5% CLA vitamin E-deficient diet, or 1.5% CLA vitamin E-deficient diet for 5 wk. Hepatic thiobarbituric acid reactive substances (TBARS) were increased in the vitamin E-deficient control group, but they were was significantly lowered in the CLA groups. Similarly, hepatic glutathione peroxidase activity was increased in the vitamin E-deficient diet and reduced by CLA supplementation. In addition, CLA caused a significant decrease in superoxide dismutase activity while having no effect on catalase activity. Analyses of the fatty acid composition revealed that dietary CLA was incorporated into hepatic microsomal membrane dose-dependently. Compared to the vitamin E-deficient control, CLA resulted in significantly higher saturated and monounsaturated fatty acids (palmitic and oleic acids) while lowering levels of oxidation-susceptible polyunsaturated fatty acids (linoleic, linolenic, and arachidonic acids) in both plasma and hepatic membrane. The concentrations of plasma cholesterol and triacylglycerol (TG) were lower in the 1.5% CLA group than in other groups. These results suggest that dietary CLA has antiatherosclerotic and antioxidant activity by increasing oxidative stability in plasma and hepatic membrane in the vitamin E-deficient rats. SN - 0301-4800 UR - https://www.unboundmedicine.com/medline/citation/15915662/Dietary_conjugated_linoleic_acid_reduces_lipid_peroxidation_by_increasing_oxidative_stability_in_rats_ L2 - https://medlineplus.gov/antioxidants.html DB - PRIME DP - Unbound Medicine ER -