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Towards understanding the catalytic core structure of the spliceosome.
Biochem Soc Trans. 2005 Jun; 33(Pt 3):447-9.BS

Abstract

The spliceosome catalyses the splicing of nuclear pre-mRNA (precursor mRNA) in eukaryotes. Pre-mRNA splicing is essential to remove internal non-coding regions of pre-mRNA (introns) and to join the remaining segments (exons) into mRNA before translation. The spliceosome is a complex assembly of five RNAs (U1, U2, U4, U5 and U6) and many dozens of associated proteins. Although a high-resolution structure of the spliceosome is not yet available, inroads have been made towards understanding its structure and function. There is growing evidence suggesting that U2 and U6 RNAs, of the five, may contribute to the catalysis of pre-mRNA splicing. In this review, recent progress towards understanding the structure and function of U2 and U6 RNAs is summarized.

Authors+Show Affiliations

Departments of Biochemistry and Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA. butcher@nmrfam.wisc.eduNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15916538

Citation

Butcher, S E., and D A. Brow. "Towards Understanding the Catalytic Core Structure of the Spliceosome." Biochemical Society Transactions, vol. 33, no. Pt 3, 2005, pp. 447-9.
Butcher SE, Brow DA. Towards understanding the catalytic core structure of the spliceosome. Biochem Soc Trans. 2005;33(Pt 3):447-9.
Butcher, S. E., & Brow, D. A. (2005). Towards understanding the catalytic core structure of the spliceosome. Biochemical Society Transactions, 33(Pt 3), 447-9.
Butcher SE, Brow DA. Towards Understanding the Catalytic Core Structure of the Spliceosome. Biochem Soc Trans. 2005;33(Pt 3):447-9. PubMed PMID: 15916538.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Towards understanding the catalytic core structure of the spliceosome. AU - Butcher,S E, AU - Brow,D A, PY - 2005/5/27/pubmed PY - 2005/8/17/medline PY - 2005/5/27/entrez SP - 447 EP - 9 JF - Biochemical Society transactions JO - Biochem Soc Trans VL - 33 IS - Pt 3 N2 - The spliceosome catalyses the splicing of nuclear pre-mRNA (precursor mRNA) in eukaryotes. Pre-mRNA splicing is essential to remove internal non-coding regions of pre-mRNA (introns) and to join the remaining segments (exons) into mRNA before translation. The spliceosome is a complex assembly of five RNAs (U1, U2, U4, U5 and U6) and many dozens of associated proteins. Although a high-resolution structure of the spliceosome is not yet available, inroads have been made towards understanding its structure and function. There is growing evidence suggesting that U2 and U6 RNAs, of the five, may contribute to the catalysis of pre-mRNA splicing. In this review, recent progress towards understanding the structure and function of U2 and U6 RNAs is summarized. SN - 0300-5127 UR - https://www.unboundmedicine.com/medline/citation/15916538/Towards_understanding_the_catalytic_core_structure_of_the_spliceosome_ L2 - https://portlandpress.com/biochemsoctrans/article-lookup/doi/10.1042/BST0330447 DB - PRIME DP - Unbound Medicine ER -