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ACE gene is associated with Alzheimer's disease and atrophy of hippocampus and amygdala.
Neurobiol Aging 2005 Aug-Sep; 26(8):1153-9NA

Abstract

Despite biological support for a role of angiotensin converting enzyme (ACE) in Alzheimer's disease (AD), studies assessing the ACE I/D polymorphism in AD are conflicting. We re-evaluated this association in the Rotterdam Study, a population-based cohort study. The mechanism of association was further explored by adjusting for vascular factors, and by analysing atrophy, white matter lesions and infarcts on MRI in non-demented individuals. Genotypes were available for 6488 participants. During average follow-up of 6 years 250 subjects developed AD. MRI data were available for 494 non-demented participants. Homozygosity for the I-allele conferred a slightly increased risk of AD compared to carrying a D-allele (RR 1.12 (95% CI 0.99-1.25)). This increase was only significant in women, and independent of vascular factors (RR 1.39 (95% CI 1.14-1.69)). Non-demented women with the II genotype had smaller hippocampal and amygdalar volumes. Vascular pathology was not significantly associated with ACE. This suggests a modest but significant increase in risk of AD and early AD pathology in women homozygous for the ACE I-allele independent of vascular factors.

Authors+Show Affiliations

Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15917098

Citation

Sleegers, Kristel, et al. "ACE Gene Is Associated With Alzheimer's Disease and Atrophy of Hippocampus and Amygdala." Neurobiology of Aging, vol. 26, no. 8, 2005, pp. 1153-9.
Sleegers K, den Heijer T, van Dijk EJ, et al. ACE gene is associated with Alzheimer's disease and atrophy of hippocampus and amygdala. Neurobiol Aging. 2005;26(8):1153-9.
Sleegers, K., den Heijer, T., van Dijk, E. J., Hofman, A., Bertoli-Avella, A. M., Koudstaal, P. J., ... van Duijn, C. M. (2005). ACE gene is associated with Alzheimer's disease and atrophy of hippocampus and amygdala. Neurobiology of Aging, 26(8), pp. 1153-9.
Sleegers K, et al. ACE Gene Is Associated With Alzheimer's Disease and Atrophy of Hippocampus and Amygdala. Neurobiol Aging. 2005;26(8):1153-9. PubMed PMID: 15917098.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - ACE gene is associated with Alzheimer's disease and atrophy of hippocampus and amygdala. AU - Sleegers,Kristel, AU - den Heijer,Tom, AU - van Dijk,Ewoud J, AU - Hofman,Albert, AU - Bertoli-Avella,Aida M, AU - Koudstaal,Peter J, AU - Breteler,Monique M B, AU - van Duijn,Cornelia M, Y1 - 2004/11/24/ PY - 2004/06/28/received PY - 2004/09/27/revised PY - 2004/09/28/accepted PY - 2005/5/27/pubmed PY - 2005/8/19/medline PY - 2005/5/27/entrez SP - 1153 EP - 9 JF - Neurobiology of aging JO - Neurobiol. Aging VL - 26 IS - 8 N2 - Despite biological support for a role of angiotensin converting enzyme (ACE) in Alzheimer's disease (AD), studies assessing the ACE I/D polymorphism in AD are conflicting. We re-evaluated this association in the Rotterdam Study, a population-based cohort study. The mechanism of association was further explored by adjusting for vascular factors, and by analysing atrophy, white matter lesions and infarcts on MRI in non-demented individuals. Genotypes were available for 6488 participants. During average follow-up of 6 years 250 subjects developed AD. MRI data were available for 494 non-demented participants. Homozygosity for the I-allele conferred a slightly increased risk of AD compared to carrying a D-allele (RR 1.12 (95% CI 0.99-1.25)). This increase was only significant in women, and independent of vascular factors (RR 1.39 (95% CI 1.14-1.69)). Non-demented women with the II genotype had smaller hippocampal and amygdalar volumes. Vascular pathology was not significantly associated with ACE. This suggests a modest but significant increase in risk of AD and early AD pathology in women homozygous for the ACE I-allele independent of vascular factors. SN - 0197-4580 UR - https://www.unboundmedicine.com/medline/citation/15917098/ACE_gene_is_associated_with_Alzheimer's_disease_and_atrophy_of_hippocampus_and_amygdala_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0197-4580(04)00315-X DB - PRIME DP - Unbound Medicine ER -