Tags

Type your tag names separated by a space and hit enter

Influence of metabolic syndrome, viral genotype and antiviral therapy on superimposed fatty liver disease in chronic hepatitis C.
Antivir Ther. 2005; 10(3):405-15.AT

Abstract

BACKGROUND/AIMS

The prevalence and clinical implications of non-alcoholic fatty liver disease in patients with chronic hepatitis C remain unknown in Taiwan.

METHODS

We addressed the relevant issues by analysing 95 naive Taiwanese patients infected with either hepatitis C virus (HCV) genotype 1 (n = 57) or 2 (n = 38), receiving interferon alone (n = 41) or in combination with ribavirin (n=54) therapy. A single pathologist scored steatosis and steatohepatitis at baseline and 24 weeks after antiviral treatment.

RESULTS

At baseline, steatosis and steatohepatitis were present in 44 (46%) and four (4%) patients, respectively. Variables associated with steatosis in logistical regression were hyperglycaemia (P = 0.01), hypertriglyceridaemia (P = 004) and body mass index > or = 27 (P = 0.009), but not HCV genotype or viral load. The grade of steatosis correlated well with the number of metabolic syndrome parameters (P = 0.018). Interferon monotherapy, advanced age and HCV genotype 1, but not steatosis, correlated with lower sustained response rate. After treatment, steatosis improved in 19 and worsened in nine, which also did not correlate with HCV genotype (P = 0.850) or sustained response to antiviral therapy (P = 0.246).

CONCLUSIONS

Hepatic steatosis in Taiwanese patients with chronic hepatitis C was associated with features of the metabolic syndrome, but did not correlate with HCV genotype, advanced fibrosis or the response to antiviral therapy.

Authors+Show Affiliations

Division of Gastroenterology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15918331

Citation

Liu, Chun-Jen, et al. "Influence of Metabolic Syndrome, Viral Genotype and Antiviral Therapy On Superimposed Fatty Liver Disease in Chronic Hepatitis C." Antiviral Therapy, vol. 10, no. 3, 2005, pp. 405-15.
Liu CJ, Jeng YM, Chen PJ, et al. Influence of metabolic syndrome, viral genotype and antiviral therapy on superimposed fatty liver disease in chronic hepatitis C. Antivir Ther. 2005;10(3):405-15.
Liu, C. J., Jeng, Y. M., Chen, P. J., Lai, M. Y., Yang, H. C., Huang, W. L., Kao, J. H., & Chen, D. S. (2005). Influence of metabolic syndrome, viral genotype and antiviral therapy on superimposed fatty liver disease in chronic hepatitis C. Antiviral Therapy, 10(3), 405-15.
Liu CJ, et al. Influence of Metabolic Syndrome, Viral Genotype and Antiviral Therapy On Superimposed Fatty Liver Disease in Chronic Hepatitis C. Antivir Ther. 2005;10(3):405-15. PubMed PMID: 15918331.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of metabolic syndrome, viral genotype and antiviral therapy on superimposed fatty liver disease in chronic hepatitis C. AU - Liu,Chun-Jen, AU - Jeng,Yung-Ming, AU - Chen,Pei-Jer, AU - Lai,Ming-Yang, AU - Yang,Hung-Chih, AU - Huang,Wen-Ling, AU - Kao,Jia-Horng, AU - Chen,Ding-Shinn, PY - 2005/5/28/pubmed PY - 2005/6/23/medline PY - 2005/5/28/entrez SP - 405 EP - 15 JF - Antiviral therapy JO - Antivir Ther VL - 10 IS - 3 N2 - BACKGROUND/AIMS: The prevalence and clinical implications of non-alcoholic fatty liver disease in patients with chronic hepatitis C remain unknown in Taiwan. METHODS: We addressed the relevant issues by analysing 95 naive Taiwanese patients infected with either hepatitis C virus (HCV) genotype 1 (n = 57) or 2 (n = 38), receiving interferon alone (n = 41) or in combination with ribavirin (n=54) therapy. A single pathologist scored steatosis and steatohepatitis at baseline and 24 weeks after antiviral treatment. RESULTS: At baseline, steatosis and steatohepatitis were present in 44 (46%) and four (4%) patients, respectively. Variables associated with steatosis in logistical regression were hyperglycaemia (P = 0.01), hypertriglyceridaemia (P = 004) and body mass index > or = 27 (P = 0.009), but not HCV genotype or viral load. The grade of steatosis correlated well with the number of metabolic syndrome parameters (P = 0.018). Interferon monotherapy, advanced age and HCV genotype 1, but not steatosis, correlated with lower sustained response rate. After treatment, steatosis improved in 19 and worsened in nine, which also did not correlate with HCV genotype (P = 0.850) or sustained response to antiviral therapy (P = 0.246). CONCLUSIONS: Hepatic steatosis in Taiwanese patients with chronic hepatitis C was associated with features of the metabolic syndrome, but did not correlate with HCV genotype, advanced fibrosis or the response to antiviral therapy. SN - 1359-6535 UR - https://www.unboundmedicine.com/medline/citation/15918331/Influence_of_metabolic_syndrome_viral_genotype_and_antiviral_therapy_on_superimposed_fatty_liver_disease_in_chronic_hepatitis_C_ L2 - http://www.diseaseinfosearch.org/result/1010 DB - PRIME DP - Unbound Medicine ER -