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Modified vaccinia virus Ankara protects macaques against respiratory challenge with monkeypox virus.
J Virol. 2005 Jun; 79(12):7845-51.JV

Abstract

The use of classical smallpox vaccines based on vaccinia virus (VV) is associated with severe complications in both naive and immune individuals. Modified vaccinia virus Ankara (MVA), a highly attenuated replication-deficient strain of VV, has been proven to be safe in humans and immunocompromised animals, and its efficacy against smallpox is currently being addressed. Here we directly compare the efficacies of MVA alone and in combination with classical VV-based vaccines in a cynomolgus macaque monkeypox model. The MVA-based smallpox vaccine protected macaques against a lethal respiratory challenge with monkeypox virus and is therefore an important candidate for the protection of humans against smallpox.

Links

Publisher Full Text
ncbi.nlm.nih.gov
journals.asm.org
PMC Free PDF

Authors+Show Affiliations

Stittelaar KJ
Department of Virology, Erasmus MC, Building Hoboken, Room Ee 17.26, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands.
van Amerongen G
No affiliation info available
Kondova I
No affiliation info available
Kuiken T
No affiliation info available
van Lavieren RF
No affiliation info available
Pistoor FH
No affiliation info available
Niesters HG
No affiliation info available
van Doornum G
No affiliation info available
van der Zeijst BA
No affiliation info available
Mateo L
No affiliation info available
Chaplin PJ
No affiliation info available
Osterhaus AD
No affiliation info available

MeSH

AnimalsAntibodies, ViralDisease Models, AnimalHumansImmunizationLungMacaca fascicularisMonkeypoxMonkeypox virusRespiratory Tract InfectionsSkinSmallpox VaccineT-LymphocytesVaccinia virus

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15919938

Citation

Stittelaar, Koert J., et al. "Modified Vaccinia Virus Ankara Protects Macaques Against Respiratory Challenge With Monkeypox Virus." Journal of Virology, vol. 79, no. 12, 2005, pp. 7845-51.
Stittelaar KJ, van Amerongen G, Kondova I, et al. Modified vaccinia virus Ankara protects macaques against respiratory challenge with monkeypox virus. J Virol. 2005;79(12):7845-51.
Stittelaar, K. J., van Amerongen, G., Kondova, I., Kuiken, T., van Lavieren, R. F., Pistoor, F. H., Niesters, H. G., van Doornum, G., van der Zeijst, B. A., Mateo, L., Chaplin, P. J., & Osterhaus, A. D. (2005). Modified vaccinia virus Ankara protects macaques against respiratory challenge with monkeypox virus. Journal of Virology, 79(12), 7845-51.
Stittelaar KJ, et al. Modified Vaccinia Virus Ankara Protects Macaques Against Respiratory Challenge With Monkeypox Virus. J Virol. 2005;79(12):7845-51. PubMed PMID: 15919938.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modified vaccinia virus Ankara protects macaques against respiratory challenge with monkeypox virus. AU - Stittelaar,Koert J, AU - van Amerongen,Geert, AU - Kondova,Ivanela, AU - Kuiken,Thijs, AU - van Lavieren,Rob F, AU - Pistoor,Frank H M, AU - Niesters,Hubert G M, AU - van Doornum,Gerard, AU - van der Zeijst,Ben A M, AU - Mateo,Luis, AU - Chaplin,Paul J, AU - Osterhaus,Albert D M E, PY - 2005/5/28/pubmed PY - 2005/6/29/medline PY - 2005/5/28/entrez SP - 7845 EP - 51 JF - Journal of virology JO - J Virol VL - 79 IS - 12 N2 - The use of classical smallpox vaccines based on vaccinia virus (VV) is associated with severe complications in both naive and immune individuals. Modified vaccinia virus Ankara (MVA), a highly attenuated replication-deficient strain of VV, has been proven to be safe in humans and immunocompromised animals, and its efficacy against smallpox is currently being addressed. Here we directly compare the efficacies of MVA alone and in combination with classical VV-based vaccines in a cynomolgus macaque monkeypox model. The MVA-based smallpox vaccine protected macaques against a lethal respiratory challenge with monkeypox virus and is therefore an important candidate for the protection of humans against smallpox. SN - 0022-538X UR - https://www.unboundmedicine.com/medline/citation/15919938/Modified_vaccinia_virus_Ankara_protects_macaques_against_respiratory_challenge_with_monkeypox_virus_ L2 - https://journals.asm.org/doi/10.1128/JVI.79.12.7845-7851.2005?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -