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A prospective study of soluble tumor necrosis factor-alpha receptor II (sTNF-RII) and risk of coronary heart disease among women with type 2 diabetes.
Diabetes Care 2005; 28(6):1376-82DC

Abstract

OBJECTIVE

Tumor necrosis factor-alpha (TNF-alpha), a cytokine secreted by adipose tissue and other cells, might play a role in insulin resistance.

RESEARCH DESIGN AND METHODS

Of 32,826 women from the Nurses' Health Study who provided blood at baseline, we followed 929 women with type 2 diabetes. During 10 years of follow-up, we documented 124 incident cases of coronary heart disease (CHD).

RESULTS

After adjustment for age, smoking, BMI, and other cardiovascular risk factors, the relative risks (RRs) comparing extreme quartiles of soluble TNF-alpha receptor II (sTNF-RII) were 2.48 (95% CI 1.08-5.69; P = 0.034) for myocardial infarction (MI) and 2.02 (1.17-3.48; P = 0.003) for total CHD. The probability of developing CHD over 10 years was higher among diabetic subjects with substantially higher levels of both sTNF-RII (>75th percentile) and HbA(1c) (>7%), compared with diabetic subjects with lower levels (25% vs. 7%, P < 0.0001). Diabetic subjects with only higher sTNF-RII or HbA(1c) had similar (16-17%) risk. In a multivariate model, diabetic subjects with higher levels of both sTNF-RII and HbA(1c) had an RR of 3.66 (1.85-7.22) for MI and 3.03 (1.82-5.05) for total CHD, compared with those with lower levels of both biomarkers.

CONCLUSIONS

Increased levels of sTNF-RII were strongly associated with risk of CHD among diabetic women, independent of hyperglycemia.

Authors+Show Affiliations

Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA. ishai@hsph.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15920055

Citation

Shai, Iris, et al. "A Prospective Study of Soluble Tumor Necrosis Factor-alpha Receptor II (sTNF-RII) and Risk of Coronary Heart Disease Among Women With Type 2 Diabetes." Diabetes Care, vol. 28, no. 6, 2005, pp. 1376-82.
Shai I, Schulze MB, Manson JE, et al. A prospective study of soluble tumor necrosis factor-alpha receptor II (sTNF-RII) and risk of coronary heart disease among women with type 2 diabetes. Diabetes Care. 2005;28(6):1376-82.
Shai, I., Schulze, M. B., Manson, J. E., Rexrode, K. M., Stampfer, M. J., Mantzoros, C., & Hu, F. B. (2005). A prospective study of soluble tumor necrosis factor-alpha receptor II (sTNF-RII) and risk of coronary heart disease among women with type 2 diabetes. Diabetes Care, 28(6), pp. 1376-82.
Shai I, et al. A Prospective Study of Soluble Tumor Necrosis Factor-alpha Receptor II (sTNF-RII) and Risk of Coronary Heart Disease Among Women With Type 2 Diabetes. Diabetes Care. 2005;28(6):1376-82. PubMed PMID: 15920055.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A prospective study of soluble tumor necrosis factor-alpha receptor II (sTNF-RII) and risk of coronary heart disease among women with type 2 diabetes. AU - Shai,Iris, AU - Schulze,Matthias B, AU - Manson,Joann E, AU - Rexrode,Kathryn M, AU - Stampfer,Meir J, AU - Mantzoros,Christos, AU - Hu,Frank B, PY - 2005/5/28/pubmed PY - 2005/9/21/medline PY - 2005/5/28/entrez SP - 1376 EP - 82 JF - Diabetes care JO - Diabetes Care VL - 28 IS - 6 N2 - OBJECTIVE: Tumor necrosis factor-alpha (TNF-alpha), a cytokine secreted by adipose tissue and other cells, might play a role in insulin resistance. RESEARCH DESIGN AND METHODS: Of 32,826 women from the Nurses' Health Study who provided blood at baseline, we followed 929 women with type 2 diabetes. During 10 years of follow-up, we documented 124 incident cases of coronary heart disease (CHD). RESULTS: After adjustment for age, smoking, BMI, and other cardiovascular risk factors, the relative risks (RRs) comparing extreme quartiles of soluble TNF-alpha receptor II (sTNF-RII) were 2.48 (95% CI 1.08-5.69; P = 0.034) for myocardial infarction (MI) and 2.02 (1.17-3.48; P = 0.003) for total CHD. The probability of developing CHD over 10 years was higher among diabetic subjects with substantially higher levels of both sTNF-RII (>75th percentile) and HbA(1c) (>7%), compared with diabetic subjects with lower levels (25% vs. 7%, P < 0.0001). Diabetic subjects with only higher sTNF-RII or HbA(1c) had similar (16-17%) risk. In a multivariate model, diabetic subjects with higher levels of both sTNF-RII and HbA(1c) had an RR of 3.66 (1.85-7.22) for MI and 3.03 (1.82-5.05) for total CHD, compared with those with lower levels of both biomarkers. CONCLUSIONS: Increased levels of sTNF-RII were strongly associated with risk of CHD among diabetic women, independent of hyperglycemia. SN - 0149-5992 UR - https://www.unboundmedicine.com/medline/citation/15920055/A_prospective_study_of_soluble_tumor_necrosis_factor_alpha_receptor_II__sTNF_RII__and_risk_of_coronary_heart_disease_among_women_with_type_2_diabetes_ L2 - http://care.diabetesjournals.org/cgi/pmidlookup?view=long&amp;pmid=15920055 DB - PRIME DP - Unbound Medicine ER -