Tags

Type your tag names separated by a space and hit enter

Cytotoxic sesquiterpene lactones from Eupatorium kiirunense, a coastal plant of Taiwan.
J Nat Prod. 2005 May; 68(5):745-50.JN

Abstract

Phytochemical investigation of Eupatorium kiirunense has resulted in the isolation of eight new sesquiterpene lactones, constituted by five germacranolides, eupakirunsins A-E (1-5), and three heliangolides, eupaheliangolide A (6), 15-acetoxyheliangin (7), and 3-epi-heliangin (8), in addition to the known heliangin (9) and 8,10-epoxy-9-acetoxythymol angelate (10). The structures of the new compounds were established through detailed analysis of their spectroscopic data. Compounds 6, 8, and 9 exhibited cytotoxicity against human oral epidermoid (KB), cervical epitheloid (Hela), and liver (hepa59T/VGH) carcinoma cells.

Authors+Show Affiliations

Shen YC
Institute of Marine Resources, National Sun Yat-sen University, 70 Lien-Hai Road, Kaohsiung, Taiwan 80424, Republic of China.
Lo KL
No affiliation info available
Kuo YH
No affiliation info available
Khalil AT
No affiliation info available

MeSH

Antineoplastic Agents, PhytogenicDrug Screening Assays, AntitumorEupatoriumHeLa CellsHumansKB CellsLactonesMolecular StructureNuclear Magnetic Resonance, BiomolecularPlant LeavesPlants, MedicinalSesquiterpenesTaiwanTumor Cells, Cultured

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15921421

Citation

Shen, Ya-Ching, et al. "Cytotoxic Sesquiterpene Lactones From Eupatorium Kiirunense, a Coastal Plant of Taiwan." Journal of Natural Products, vol. 68, no. 5, 2005, pp. 745-50.
Shen YC, Lo KL, Kuo YH, et al. Cytotoxic sesquiterpene lactones from Eupatorium kiirunense, a coastal plant of Taiwan. J Nat Prod. 2005;68(5):745-50.
Shen, Y. C., Lo, K. L., Kuo, Y. H., & Khalil, A. T. (2005). Cytotoxic sesquiterpene lactones from Eupatorium kiirunense, a coastal plant of Taiwan. Journal of Natural Products, 68(5), 745-50.
Shen YC, et al. Cytotoxic Sesquiterpene Lactones From Eupatorium Kiirunense, a Coastal Plant of Taiwan. J Nat Prod. 2005;68(5):745-50. PubMed PMID: 15921421.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytotoxic sesquiterpene lactones from Eupatorium kiirunense, a coastal plant of Taiwan. AU - Shen,Ya-Ching, AU - Lo,Kuang-Liang, AU - Kuo,Yao Haur, AU - Khalil,Ashraf Taha, PY - 2005/6/1/pubmed PY - 2005/7/8/medline PY - 2005/6/1/entrez SP - 745 EP - 50 JF - Journal of natural products JO - J Nat Prod VL - 68 IS - 5 N2 - Phytochemical investigation of Eupatorium kiirunense has resulted in the isolation of eight new sesquiterpene lactones, constituted by five germacranolides, eupakirunsins A-E (1-5), and three heliangolides, eupaheliangolide A (6), 15-acetoxyheliangin (7), and 3-epi-heliangin (8), in addition to the known heliangin (9) and 8,10-epoxy-9-acetoxythymol angelate (10). The structures of the new compounds were established through detailed analysis of their spectroscopic data. Compounds 6, 8, and 9 exhibited cytotoxicity against human oral epidermoid (KB), cervical epitheloid (Hela), and liver (hepa59T/VGH) carcinoma cells. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/15921421/Cytotoxic_sesquiterpene_lactones_from_Eupatorium_kiirunense_a_coastal_plant_of_Taiwan_ DB - PRIME DP - Unbound Medicine ER -