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Pseudoguanolide sesquiterpene lactones from Vernoniopsis caudata and their in vitro antiplasmodial activities.
J Nat Prod. 2005 May; 68(5):800-3.JN

Abstract

Two new helenanolide sesquiterpene lactones, 1 and 2, as well as one known related structure, 11alpha,13-dihydrohelenalin-[2-(1-hydroxyethyl)acrylate] (3), together with 4'-beta-d-O-glucopyranosyl-luteolin and ethyl 2,5-dihydroxycinnamate were isolated from an ethyl acetate extract of leaves of Vernoniopsis caudatawith potent antiplasmodial activity (IC50 1.6 microg/mL) in a preliminary biological screen. The structures of the new compounds were determined by spectroscopic techniques. The three sesquiterpene lactones 1-3 displayed strong in vitro antiplasmodial activity, with IC50 values of 1, 0.19, and 0.41 microM, respectively. However, these compounds also exhibited considerable cytotoxicity on KB cells (IC50 < 1 microM in each case).

Authors+Show Affiliations

Ramanandraibe V
Laboratoire de Pharmacognosie Appliquée aux Maladies Infectieuses, Institut Malgache de Recherches Appliquées, BP 3833, 101 Antananarivo, Madagascar.
Martin MT
No affiliation info available
Rakotondramanana DL
No affiliation info available
Mambu L
No affiliation info available
Ramanitrahasimbola D
No affiliation info available
Labaïed M
No affiliation info available
Grellier P
No affiliation info available
Rasoanaivo P
No affiliation info available
Frappier F
No affiliation info available

MeSH

AntimalarialsAntineoplastic Agents, PhytogenicAsteraceaeDrug Screening Assays, AntitumorHumansInhibitory Concentration 50KB CellsLactonesMadagascarPlant LeavesPlants, MedicinalSesquiterpenesSesquiterpenes, GuaianeTumor Cells, Cultured

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15921436

Citation

Ramanandraibe, Voahangy, et al. "Pseudoguanolide Sesquiterpene Lactones From Vernoniopsis Caudata and Their in Vitro Antiplasmodial Activities." Journal of Natural Products, vol. 68, no. 5, 2005, pp. 800-3.
Ramanandraibe V, Martin MT, Rakotondramanana DL, et al. Pseudoguanolide sesquiterpene lactones from Vernoniopsis caudata and their in vitro antiplasmodial activities. J Nat Prod. 2005;68(5):800-3.
Ramanandraibe, V., Martin, M. T., Rakotondramanana, D. L., Mambu, L., Ramanitrahasimbola, D., Labaïed, M., Grellier, P., Rasoanaivo, P., & Frappier, F. (2005). Pseudoguanolide sesquiterpene lactones from Vernoniopsis caudata and their in vitro antiplasmodial activities. Journal of Natural Products, 68(5), 800-3.
Ramanandraibe V, et al. Pseudoguanolide Sesquiterpene Lactones From Vernoniopsis Caudata and Their in Vitro Antiplasmodial Activities. J Nat Prod. 2005;68(5):800-3. PubMed PMID: 15921436.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pseudoguanolide sesquiterpene lactones from Vernoniopsis caudata and their in vitro antiplasmodial activities. AU - Ramanandraibe,Voahangy, AU - Martin,Marie-Thérèse, AU - Rakotondramanana,Dina L, AU - Mambu,Lengo, AU - Ramanitrahasimbola,David, AU - Labaïed,Medhi, AU - Grellier,Philippe, AU - Rasoanaivo,Philippe, AU - Frappier,François, PY - 2005/6/1/pubmed PY - 2005/7/8/medline PY - 2005/6/1/entrez SP - 800 EP - 3 JF - Journal of natural products JO - J Nat Prod VL - 68 IS - 5 N2 - Two new helenanolide sesquiterpene lactones, 1 and 2, as well as one known related structure, 11alpha,13-dihydrohelenalin-[2-(1-hydroxyethyl)acrylate] (3), together with 4'-beta-d-O-glucopyranosyl-luteolin and ethyl 2,5-dihydroxycinnamate were isolated from an ethyl acetate extract of leaves of Vernoniopsis caudatawith potent antiplasmodial activity (IC50 1.6 microg/mL) in a preliminary biological screen. The structures of the new compounds were determined by spectroscopic techniques. The three sesquiterpene lactones 1-3 displayed strong in vitro antiplasmodial activity, with IC50 values of 1, 0.19, and 0.41 microM, respectively. However, these compounds also exhibited considerable cytotoxicity on KB cells (IC50 < 1 microM in each case). SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/15921436/Pseudoguanolide_sesquiterpene_lactones_from_Vernoniopsis_caudata_and_their_in_vitro_antiplasmodial_activities_ DB - PRIME DP - Unbound Medicine ER -