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Cucurbitane-type triterpenoids from the fruit of Momordica charantia.
J Nat Prod. 2005 May; 68(5):807-9.JN

Abstract

The structures of three new cucurbitane-type triterpenoids isolated from the methanol extract of the fruit of Japanese Momordica charantia were established as (19R,23E)-5beta,19-epoxy-19-methoxycucurbita-6,23,25-trien-3beta-ol (1), (23E)-3beta-hydroxy-7beta-methoxycucurbita-5,23,25-trien-19-al (2), and (23E)-3beta-hydroxy-7beta,25-dimethoxycucurbita-5,23-dien-19-al (3) on the basis of spectroscopic methods. These compounds were accompanied by the known (19R,23E)-5beta,19-epoxy-19,25-dimethoxycucurbita-6,23-dien-3beta-ol (4) and (19R,23E)-5beta,19-epoxy-19-methoxycucurbita-6,23-diene-3beta,25-diol (5). This is the first report of the isolation of tetracyclic triterpenoids possessing a delta23,25-conjugated diene system, viz., 1 and 2, from a natural source.

Authors+Show Affiliations

Kimura Y
College of Science and Technology, Nihon University, 1-8 Kanda Surugadai, Chiyoda-ku, Tokyo 101-8308, Japan.
Akihisa T
No affiliation info available
Yuasa N
No affiliation info available
Ukiya M
No affiliation info available
Suzuki T
No affiliation info available
Toriyama M
No affiliation info available
Motohashi S
No affiliation info available
Tokuda H
No affiliation info available

MeSH

FruitJapanMolecular StructureMomordica charantiaPlants, MedicinalStereoisomerismTriterpenes

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15921438

Citation

Kimura, Yumiko, et al. "Cucurbitane-type Triterpenoids From the Fruit of Momordica Charantia." Journal of Natural Products, vol. 68, no. 5, 2005, pp. 807-9.
Kimura Y, Akihisa T, Yuasa N, et al. Cucurbitane-type triterpenoids from the fruit of Momordica charantia. J Nat Prod. 2005;68(5):807-9.
Kimura, Y., Akihisa, T., Yuasa, N., Ukiya, M., Suzuki, T., Toriyama, M., Motohashi, S., & Tokuda, H. (2005). Cucurbitane-type triterpenoids from the fruit of Momordica charantia. Journal of Natural Products, 68(5), 807-9.
Kimura Y, et al. Cucurbitane-type Triterpenoids From the Fruit of Momordica Charantia. J Nat Prod. 2005;68(5):807-9. PubMed PMID: 15921438.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cucurbitane-type triterpenoids from the fruit of Momordica charantia. AU - Kimura,Yumiko, AU - Akihisa,Toshihiro, AU - Yuasa,Noriko, AU - Ukiya,Motohiko, AU - Suzuki,Takashi, AU - Toriyama,Masaharu, AU - Motohashi,Shigeyasu, AU - Tokuda,Harukuni, PY - 2005/6/1/pubmed PY - 2005/7/8/medline PY - 2005/6/1/entrez SP - 807 EP - 9 JF - Journal of natural products JO - J Nat Prod VL - 68 IS - 5 N2 - The structures of three new cucurbitane-type triterpenoids isolated from the methanol extract of the fruit of Japanese Momordica charantia were established as (19R,23E)-5beta,19-epoxy-19-methoxycucurbita-6,23,25-trien-3beta-ol (1), (23E)-3beta-hydroxy-7beta-methoxycucurbita-5,23,25-trien-19-al (2), and (23E)-3beta-hydroxy-7beta,25-dimethoxycucurbita-5,23-dien-19-al (3) on the basis of spectroscopic methods. These compounds were accompanied by the known (19R,23E)-5beta,19-epoxy-19,25-dimethoxycucurbita-6,23-dien-3beta-ol (4) and (19R,23E)-5beta,19-epoxy-19-methoxycucurbita-6,23-diene-3beta,25-diol (5). This is the first report of the isolation of tetracyclic triterpenoids possessing a delta23,25-conjugated diene system, viz., 1 and 2, from a natural source. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/15921438/Cucurbitane_type_triterpenoids_from_the_fruit_of_Momordica_charantia_ DB - PRIME DP - Unbound Medicine ER -