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[Analysis of risk factors for the development of acute graft-versus-host disease in 151 cases of allo-hematopoietic stem cell transplantation].
Zhonghua Xue Ye Xue Za Zhi. 2005 Feb; 26(2):74-7.ZX

Abstract

OBJECTIVE

To investigate the incidence and risk factors of acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic stem cell transplantation (HSCT).

METHODS

The clinical data of 151 cases of allo-HSCT in 150 patients from Nov 2001 to Jan 2004 was analyzed.

RESULTS

aGVHD was developed in 60 cases (40.2%), including 43 cases with grade I - II and 17 with grade III - IV aGVHD, the mean time of aGVHD development was 21 days (range 1 - 85 days) after allo-HSCT, 35 out of 55 cases achieved complete response (CR) (63.6%). The early survival rate for grade I - II aGVHD was more than 90%, while that for grade III - IV aGVHD was 46%. Nineteen factors possibly correlated with the development of aGVHD were analyzed. The univariate analysis showed that recipient age, donor's sex, recipient's sex, sex and ABO blood group disparity between donor and recipient, diagnosis, the status of disease, the stage of disease, stem cell source, conditioning regimen (TBI/without TBI), CD34(+) cell number, CD3(+) cell number, early engraftment and neutropenic infection were not closely associated with the occurrence of aGVHD (P > 0.05). On the Cox regression model, 2 independent factors for grade I - IV aGVHD were identified:HLA mismatch (RR = 1.681, P < 0.05) and positive surface antigen (HBsAg) (RR = 1.907, P < 0.05). In addition, the univariate analysis showed aGVHD was strongly associated with CMV infection (P < 0.01).

CONCLUSION

aGVHD is a common complication after HSCT, HLA mismatch and HBsAg positivity are independent risk factors for aGVHD.

Authors+Show Affiliations

Institute of Hematology, People's Hospital, Peking University, Beijing 100044, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

15921621

Citation

Chen, Yao, et al. "[Analysis of Risk Factors for the Development of Acute Graft-versus-host Disease in 151 Cases of Allo-hematopoietic Stem Cell Transplantation]." Zhonghua Xue Ye Xue Za Zhi = Zhonghua Xueyexue Zazhi, vol. 26, no. 2, 2005, pp. 74-7.
Chen Y, Lu DP, Liu KY, et al. [Analysis of risk factors for the development of acute graft-versus-host disease in 151 cases of allo-hematopoietic stem cell transplantation]. Zhonghua Xue Ye Xue Za Zhi. 2005;26(2):74-7.
Chen, Y., Lu, D. P., Liu, K. Y., Dong, L. J., Ren, H. Y., Huang, X. J., Chen, H., Liu, D. H., Jiang, Q., Chen, Y. H., Xu, L. P., Zhang, Y. C., Lu, J., & Gao, Z. Y. (2005). [Analysis of risk factors for the development of acute graft-versus-host disease in 151 cases of allo-hematopoietic stem cell transplantation]. Zhonghua Xue Ye Xue Za Zhi = Zhonghua Xueyexue Zazhi, 26(2), 74-7.
Chen Y, et al. [Analysis of Risk Factors for the Development of Acute Graft-versus-host Disease in 151 Cases of Allo-hematopoietic Stem Cell Transplantation]. Zhonghua Xue Ye Xue Za Zhi. 2005;26(2):74-7. PubMed PMID: 15921621.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Analysis of risk factors for the development of acute graft-versus-host disease in 151 cases of allo-hematopoietic stem cell transplantation]. AU - Chen,Yao, AU - Lu,Dao-pei, AU - Liu,Kai-yan, AU - Dong,Lu-jia, AU - Ren,Han-yun, AU - Huang,Xiao-jun, AU - Chen,Huan, AU - Liu,Dai-hong, AU - Jiang,Qian, AU - Chen,Yu-hong, AU - Xu,Lan-ping, AU - Zhang,Yao-chen, AU - Lu,Jin, AU - Gao,Zhi-yong, PY - 2005/6/1/pubmed PY - 2009/2/10/medline PY - 2005/6/1/entrez SP - 74 EP - 7 JF - Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi JO - Zhonghua Xue Ye Xue Za Zhi VL - 26 IS - 2 N2 - OBJECTIVE: To investigate the incidence and risk factors of acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic stem cell transplantation (HSCT). METHODS: The clinical data of 151 cases of allo-HSCT in 150 patients from Nov 2001 to Jan 2004 was analyzed. RESULTS: aGVHD was developed in 60 cases (40.2%), including 43 cases with grade I - II and 17 with grade III - IV aGVHD, the mean time of aGVHD development was 21 days (range 1 - 85 days) after allo-HSCT, 35 out of 55 cases achieved complete response (CR) (63.6%). The early survival rate for grade I - II aGVHD was more than 90%, while that for grade III - IV aGVHD was 46%. Nineteen factors possibly correlated with the development of aGVHD were analyzed. The univariate analysis showed that recipient age, donor's sex, recipient's sex, sex and ABO blood group disparity between donor and recipient, diagnosis, the status of disease, the stage of disease, stem cell source, conditioning regimen (TBI/without TBI), CD34(+) cell number, CD3(+) cell number, early engraftment and neutropenic infection were not closely associated with the occurrence of aGVHD (P > 0.05). On the Cox regression model, 2 independent factors for grade I - IV aGVHD were identified:HLA mismatch (RR = 1.681, P < 0.05) and positive surface antigen (HBsAg) (RR = 1.907, P < 0.05). In addition, the univariate analysis showed aGVHD was strongly associated with CMV infection (P < 0.01). CONCLUSION: aGVHD is a common complication after HSCT, HLA mismatch and HBsAg positivity are independent risk factors for aGVHD. SN - 0253-2727 UR - https://www.unboundmedicine.com/medline/citation/15921621/[Analysis_of_risk_factors_for_the_development_of_acute_graft_versus_host_disease_in_151_cases_of_allo_hematopoietic_stem_cell_transplantation]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=0253-2727&amp;year=2005&amp;vol=26&amp;issue=2&amp;fpage=74 DB - PRIME DP - Unbound Medicine ER -