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Right ventricular dysfunction in chronic heart failure patients.
Eur J Heart Fail. 2005 Jun; 7(4):485-9.EJ

Abstract

AIM

To evaluate any differences in haemodynamic and echocardiographic parameters in patients with both left (LV) and right ventricular (RV) systolic dysfunction and in patients with isolated LV systolic dysfunction.

STUDY GROUP

One hundred patients with RV systolic dysfunction defined as peak velocity of tricuspid annular motion in systole (Sa)<11.5 cm/s, and 55 patients without RV systolic dysfunction Sa>11.5 cm/s. All patients had LV systolic dysfunction, LV ejection fraction (EF) below 40%, NYHA II-IV.

METHODS

LV diameters, volumes and EF were measured by echocardiography. Patients underwent tissue Doppler imaging (TDI) of tricuspid annular motion with measurement of peak systolic velocity (Sa), peak early (Ea) and peak late (Aa) diastolic velocities. Right heart catheterization was also performed.

RESULTS

Patients with RV systolic dysfunction did not differ from those without RV systolic dysfunction in terms of LV function. Patients with RV systolic dysfunction had larger RV dimension 30.6+/-5.8 vs. 33.9+/-6.7 mm, p<0.002. The patients with RV systolic dysfunction had higher values on right heart catheterization: MPAP 29.6+/-12.1 vs. 24.9+/-11.4 mm Hg, p<0.02, PCWP 20.8+/-10.0 vs. 17.3+/-9.3 mm Hg, p<0.03, PVR 189.9+/-123.3 vs. 137.7+/-94.9 dyn s cm(-5), p<0.008, CVP 7.7+/-5.6 vs. 5.1+/-3.9 mm Hg, p<0.002. The patients with RV systolic dysfunction had more pronounced diastolic dysfunction measured by TDI: Ea 9.9+/-2.3 vs. 11.4+/-2.5 cm/s, p<0.0001 and Aa 13.1+/-4.0 vs. 16.5+/-4.7 cm/s, p<0.000007.

CONCLUSION

Patients with heart failure and both left and right ventricular systolic dysfunction showed more serious findings on central haemodynamics as well as more pronounced right ventricular diastolic dysfunction than those with isolated left ventricular systolic dysfunction.

Authors+Show Affiliations

1st Cardio-angiologic Department, University Hospital, Pekarská 53, 656 91 Brno, Czech Republic. lenka.spinarova@fnusa.czNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15921784

Citation

Spinarová, Lenka, et al. "Right Ventricular Dysfunction in Chronic Heart Failure Patients." European Journal of Heart Failure, vol. 7, no. 4, 2005, pp. 485-9.
Spinarová L, Meluzín J, Toman J, et al. Right ventricular dysfunction in chronic heart failure patients. Eur J Heart Fail. 2005;7(4):485-9.
Spinarová, L., Meluzín, J., Toman, J., Hude, P., Krejcí, J., & Vítovec, J. (2005). Right ventricular dysfunction in chronic heart failure patients. European Journal of Heart Failure, 7(4), 485-9.
Spinarová L, et al. Right Ventricular Dysfunction in Chronic Heart Failure Patients. Eur J Heart Fail. 2005;7(4):485-9. PubMed PMID: 15921784.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Right ventricular dysfunction in chronic heart failure patients. AU - Spinarová,Lenka, AU - Meluzín,Jaroslav, AU - Toman,Jirí, AU - Hude,Petr, AU - Krejcí,Jan, AU - Vítovec,Jirí, PY - 2003/10/08/received PY - 2004/01/20/revised PY - 2004/07/09/accepted PY - 2005/6/1/pubmed PY - 2005/9/28/medline PY - 2005/6/1/entrez SP - 485 EP - 9 JF - European journal of heart failure JO - Eur. J. Heart Fail. VL - 7 IS - 4 N2 - AIM: To evaluate any differences in haemodynamic and echocardiographic parameters in patients with both left (LV) and right ventricular (RV) systolic dysfunction and in patients with isolated LV systolic dysfunction. STUDY GROUP: One hundred patients with RV systolic dysfunction defined as peak velocity of tricuspid annular motion in systole (Sa)<11.5 cm/s, and 55 patients without RV systolic dysfunction Sa>11.5 cm/s. All patients had LV systolic dysfunction, LV ejection fraction (EF) below 40%, NYHA II-IV. METHODS: LV diameters, volumes and EF were measured by echocardiography. Patients underwent tissue Doppler imaging (TDI) of tricuspid annular motion with measurement of peak systolic velocity (Sa), peak early (Ea) and peak late (Aa) diastolic velocities. Right heart catheterization was also performed. RESULTS: Patients with RV systolic dysfunction did not differ from those without RV systolic dysfunction in terms of LV function. Patients with RV systolic dysfunction had larger RV dimension 30.6+/-5.8 vs. 33.9+/-6.7 mm, p<0.002. The patients with RV systolic dysfunction had higher values on right heart catheterization: MPAP 29.6+/-12.1 vs. 24.9+/-11.4 mm Hg, p<0.02, PCWP 20.8+/-10.0 vs. 17.3+/-9.3 mm Hg, p<0.03, PVR 189.9+/-123.3 vs. 137.7+/-94.9 dyn s cm(-5), p<0.008, CVP 7.7+/-5.6 vs. 5.1+/-3.9 mm Hg, p<0.002. The patients with RV systolic dysfunction had more pronounced diastolic dysfunction measured by TDI: Ea 9.9+/-2.3 vs. 11.4+/-2.5 cm/s, p<0.0001 and Aa 13.1+/-4.0 vs. 16.5+/-4.7 cm/s, p<0.000007. CONCLUSION: Patients with heart failure and both left and right ventricular systolic dysfunction showed more serious findings on central haemodynamics as well as more pronounced right ventricular diastolic dysfunction than those with isolated left ventricular systolic dysfunction. SN - 1388-9842 UR - https://www.unboundmedicine.com/medline/citation/15921784/Right_ventricular_dysfunction_in_chronic_heart_failure_patients_ L2 - https://doi.org/10.1016/j.ejheart.2004.07.017 DB - PRIME DP - Unbound Medicine ER -