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The cholinergic anti-inflammatory pathway.
Brain Behav Immun. 2005 Nov; 19(6):493-9.BB

Abstract

The regulation of the innate immune response is critical for controlling inflammation and for the prevention and treatment of diseases. We recently demonstrated that the efferent vagus nerve inhibits pro-inflammatory cytokine release and protects against systemic inflammation, and termed this vagal function "the cholinergic anti-inflammatory pathway." The discovery that the innate immune response is regulated partially through this neural pathway provides a new understanding of the mechanisms that control inflammation. In this review, we outline the cholinergic anti-inflammatory pathway and summarize the current insights into the mechanisms of cholinergic modulation of inflammation. We also discuss possible clinical implications of vagus nerve stimulation and cholinergic modalities in the treatment of inflammatory diseases.

Authors+Show Affiliations

Laboratory of Biomedical Science, Institute for Medical Research North Shore-LIJ Health System, Manhasset, NY 11030, USA. vpavlov@nshs.eduNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Review

Language

eng

PubMed ID

15922555

Citation

Pavlov, Valentin A., and Kevin J. Tracey. "The Cholinergic Anti-inflammatory Pathway." Brain, Behavior, and Immunity, vol. 19, no. 6, 2005, pp. 493-9.
Pavlov VA, Tracey KJ. The cholinergic anti-inflammatory pathway. Brain Behav Immun. 2005;19(6):493-9.
Pavlov, V. A., & Tracey, K. J. (2005). The cholinergic anti-inflammatory pathway. Brain, Behavior, and Immunity, 19(6), 493-9.
Pavlov VA, Tracey KJ. The Cholinergic Anti-inflammatory Pathway. Brain Behav Immun. 2005;19(6):493-9. PubMed PMID: 15922555.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The cholinergic anti-inflammatory pathway. AU - Pavlov,Valentin A, AU - Tracey,Kevin J, PY - 2005/01/28/received PY - 2005/03/13/revised PY - 2005/03/31/accepted PY - 2005/6/1/pubmed PY - 2006/2/7/medline PY - 2005/6/1/entrez SP - 493 EP - 9 JF - Brain, behavior, and immunity JO - Brain Behav Immun VL - 19 IS - 6 N2 - The regulation of the innate immune response is critical for controlling inflammation and for the prevention and treatment of diseases. We recently demonstrated that the efferent vagus nerve inhibits pro-inflammatory cytokine release and protects against systemic inflammation, and termed this vagal function "the cholinergic anti-inflammatory pathway." The discovery that the innate immune response is regulated partially through this neural pathway provides a new understanding of the mechanisms that control inflammation. In this review, we outline the cholinergic anti-inflammatory pathway and summarize the current insights into the mechanisms of cholinergic modulation of inflammation. We also discuss possible clinical implications of vagus nerve stimulation and cholinergic modalities in the treatment of inflammatory diseases. SN - 0889-1591 UR - https://www.unboundmedicine.com/medline/citation/15922555/The_cholinergic_anti_inflammatory_pathway_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0889-1591(05)00066-8 DB - PRIME DP - Unbound Medicine ER -