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Estrogen receptor-alpha and -beta immunoreactive neurons in the brainstem and spinal cord of male and female mice: relationships to monoaminergic, cholinergic, and spinal projection systems.
J Comp Neurol. 2005 Jul 25; 488(2):152-79.JC

Abstract

For many populations of estrogen-sensitive neurons it remains unknown how they are associated with central nervous system circuitries that mediate estrogen-induced modulation of behavioral components. With the use of double-labeling immunohistochemistry and tracing techniques, the relationships of estrogen receptor (ER)-alpha- and ER-beta-immunoreactive (IR) neurons in the mouse brainstem and spinal cord to monoaminergic, cholinergic, and spinal projection systems are explored. Similar distributions of ER-IR neurons were present in females and males, with differences in labeling intensity of ER-alpha immunoreactivity among males and estrogen-, and oil-treated females. Barrington's nucleus, the ventrolateral medulla, and the nucleus of the solitary tract contained spinal-projecting ER-alpha-IR neurons, whereas ER-alpha-IR neurons in the periaqueductal gray, parabrachial nucleus, and catecholaminergic A1 cell group received spinal input. Numerous tyrosine hydroxylase (TH)-IR ER-alpha-IR neurons were present in the ventral periaqueductal gray, nucleus of the solitary tract, A1 cell group, and lumbosacral cord. The dorsal raphe nucleus contained ER-alpha-IR and ER-beta-IR neurons that colocalized with serotonin (5HT), and the reticulotegmental nucleus contained 5HT-IR ER-alpha-IR neurons. Fibers IR for vesicular acetylcholine transporter (VAChT), TH, and 5HT were located among ER-alpha-IR neurons in the dorsal horn and spinal autonomic regions. Robust staining for TH and VAChT, but not 5HT, was present among ER-alpha-IR neurons in the lumbosacral lateral collateral pathway. Possible modulatory actions of estrogen on each of these ER-IR populations are discussed in the context of their specific function, including micturition, sexual behavior, ejaculation, cardiovascular and respiratory control, tactile and nociceptive sensory processing, anti-nociception, endocrine regulation, and feeding.

Authors+Show Affiliations

Department of Neuroscience, Karolinska Institutet, Stockholm S-17177, Sweden. veronique.van.der.horst@neuro.ki.seNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15924341

Citation

Vanderhorst, Veronique G J M., et al. "Estrogen Receptor-alpha and -beta Immunoreactive Neurons in the Brainstem and Spinal Cord of Male and Female Mice: Relationships to Monoaminergic, Cholinergic, and Spinal Projection Systems." The Journal of Comparative Neurology, vol. 488, no. 2, 2005, pp. 152-79.
Vanderhorst VG, Gustafsson JA, Ulfhake B. Estrogen receptor-alpha and -beta immunoreactive neurons in the brainstem and spinal cord of male and female mice: relationships to monoaminergic, cholinergic, and spinal projection systems. J Comp Neurol. 2005;488(2):152-79.
Vanderhorst, V. G., Gustafsson, J. A., & Ulfhake, B. (2005). Estrogen receptor-alpha and -beta immunoreactive neurons in the brainstem and spinal cord of male and female mice: relationships to monoaminergic, cholinergic, and spinal projection systems. The Journal of Comparative Neurology, 488(2), 152-79.
Vanderhorst VG, Gustafsson JA, Ulfhake B. Estrogen Receptor-alpha and -beta Immunoreactive Neurons in the Brainstem and Spinal Cord of Male and Female Mice: Relationships to Monoaminergic, Cholinergic, and Spinal Projection Systems. J Comp Neurol. 2005 Jul 25;488(2):152-79. PubMed PMID: 15924341.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Estrogen receptor-alpha and -beta immunoreactive neurons in the brainstem and spinal cord of male and female mice: relationships to monoaminergic, cholinergic, and spinal projection systems. AU - Vanderhorst,Veronique G J M, AU - Gustafsson,Jan-Ake, AU - Ulfhake,Brun, PY - 2005/6/1/pubmed PY - 2005/9/1/medline PY - 2005/6/1/entrez SP - 152 EP - 79 JF - The Journal of comparative neurology JO - J Comp Neurol VL - 488 IS - 2 N2 - For many populations of estrogen-sensitive neurons it remains unknown how they are associated with central nervous system circuitries that mediate estrogen-induced modulation of behavioral components. With the use of double-labeling immunohistochemistry and tracing techniques, the relationships of estrogen receptor (ER)-alpha- and ER-beta-immunoreactive (IR) neurons in the mouse brainstem and spinal cord to monoaminergic, cholinergic, and spinal projection systems are explored. Similar distributions of ER-IR neurons were present in females and males, with differences in labeling intensity of ER-alpha immunoreactivity among males and estrogen-, and oil-treated females. Barrington's nucleus, the ventrolateral medulla, and the nucleus of the solitary tract contained spinal-projecting ER-alpha-IR neurons, whereas ER-alpha-IR neurons in the periaqueductal gray, parabrachial nucleus, and catecholaminergic A1 cell group received spinal input. Numerous tyrosine hydroxylase (TH)-IR ER-alpha-IR neurons were present in the ventral periaqueductal gray, nucleus of the solitary tract, A1 cell group, and lumbosacral cord. The dorsal raphe nucleus contained ER-alpha-IR and ER-beta-IR neurons that colocalized with serotonin (5HT), and the reticulotegmental nucleus contained 5HT-IR ER-alpha-IR neurons. Fibers IR for vesicular acetylcholine transporter (VAChT), TH, and 5HT were located among ER-alpha-IR neurons in the dorsal horn and spinal autonomic regions. Robust staining for TH and VAChT, but not 5HT, was present among ER-alpha-IR neurons in the lumbosacral lateral collateral pathway. Possible modulatory actions of estrogen on each of these ER-IR populations are discussed in the context of their specific function, including micturition, sexual behavior, ejaculation, cardiovascular and respiratory control, tactile and nociceptive sensory processing, anti-nociception, endocrine regulation, and feeding. SN - 0021-9967 UR - https://www.unboundmedicine.com/medline/citation/15924341/Estrogen_receptor_alpha_and__beta_immunoreactive_neurons_in_the_brainstem_and_spinal_cord_of_male_and_female_mice:_relationships_to_monoaminergic_cholinergic_and_spinal_projection_systems_ L2 - https://doi.org/10.1002/cne.20569 DB - PRIME DP - Unbound Medicine ER -