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Effects of chronic obesity and weight loss on plasma ghrelin and leptin concentrations in dogs.
Res Vet Sci. 2005 Oct; 79(2):169-75.RV

Abstract

The objective of this study was to evaluate, in dogs, the effects of obesity and weight loss on plasma total ghrelin and leptin concentrations. Twenty-four Beagle dogs, 12 control lean and 12 obese dogs of both genders and aged between 1 and 9 years, were used for the experiments. Mean body weight was 12.7+/-0.7 kg for the lean group and 21.9+/-0.8 kg for the obese group. The trial was divided into three phases. During phase 1, all 24 Beagle dogs were fed a maintenance diet. During phase 2, the obese dogs were submitted to a weight loss protocol with a high protein-low energy diet. The weight loss protocol ended once dogs reached optimal body weight. During phase 3, the dogs that were submitted to the weight loss protocol were maintained at their optimal body weight for 6 months. Plasma total ghrelin, leptin, insulin and glucose concentrations were measured to evaluate the effects of obesity and weight loss on these parameters in dogs. Body weight, body condition score, thoracic and pelvic perimeters, and ingested food amounts were also recorded during the study. Obese dogs demonstrated a significant decrease in plasma ghrelin and a significant increase in plasma leptin and insulin concentrations when compared with control dogs. During weight loss, significant increases in plasma total ghrelin and glucose and significant decreases in plasma leptin and insulin were observed. The increase in plasma ghrelin concentrations seemed to be transient. Body weight and the morphometric parameters correlated positively with leptin concentrations and negatively with total ghrelin concentrations. These results suggest that ghrelin and leptin could play a role in dogs in the adaptation to a positive or negative energy balance, as observed in humans.

Authors+Show Affiliations

Affinity-Petcare, 08174, Barcelona, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15924935

Citation

Jeusette, Isabelle C., et al. "Effects of Chronic Obesity and Weight Loss On Plasma Ghrelin and Leptin Concentrations in Dogs." Research in Veterinary Science, vol. 79, no. 2, 2005, pp. 169-75.
Jeusette IC, Detilleux J, Shibata H, et al. Effects of chronic obesity and weight loss on plasma ghrelin and leptin concentrations in dogs. Res Vet Sci. 2005;79(2):169-75.
Jeusette, I. C., Detilleux, J., Shibata, H., Saito, M., Honjoh, T., Delobel, A., Istasse, L., & Diez, M. (2005). Effects of chronic obesity and weight loss on plasma ghrelin and leptin concentrations in dogs. Research in Veterinary Science, 79(2), 169-75.
Jeusette IC, et al. Effects of Chronic Obesity and Weight Loss On Plasma Ghrelin and Leptin Concentrations in Dogs. Res Vet Sci. 2005;79(2):169-75. PubMed PMID: 15924935.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of chronic obesity and weight loss on plasma ghrelin and leptin concentrations in dogs. AU - Jeusette,Isabelle C, AU - Detilleux,Johanne, AU - Shibata,Haruki, AU - Saito,Masayuki, AU - Honjoh,Tsutomu, AU - Delobel,Agathe, AU - Istasse,Louis, AU - Diez,Marianne, Y1 - 2005/02/12/ PY - 2003/10/26/received PY - 2004/11/05/accepted PY - 2005/6/1/pubmed PY - 2005/8/27/medline PY - 2005/6/1/entrez SP - 169 EP - 75 JF - Research in veterinary science JO - Res. Vet. Sci. VL - 79 IS - 2 N2 - The objective of this study was to evaluate, in dogs, the effects of obesity and weight loss on plasma total ghrelin and leptin concentrations. Twenty-four Beagle dogs, 12 control lean and 12 obese dogs of both genders and aged between 1 and 9 years, were used for the experiments. Mean body weight was 12.7+/-0.7 kg for the lean group and 21.9+/-0.8 kg for the obese group. The trial was divided into three phases. During phase 1, all 24 Beagle dogs were fed a maintenance diet. During phase 2, the obese dogs were submitted to a weight loss protocol with a high protein-low energy diet. The weight loss protocol ended once dogs reached optimal body weight. During phase 3, the dogs that were submitted to the weight loss protocol were maintained at their optimal body weight for 6 months. Plasma total ghrelin, leptin, insulin and glucose concentrations were measured to evaluate the effects of obesity and weight loss on these parameters in dogs. Body weight, body condition score, thoracic and pelvic perimeters, and ingested food amounts were also recorded during the study. Obese dogs demonstrated a significant decrease in plasma ghrelin and a significant increase in plasma leptin and insulin concentrations when compared with control dogs. During weight loss, significant increases in plasma total ghrelin and glucose and significant decreases in plasma leptin and insulin were observed. The increase in plasma ghrelin concentrations seemed to be transient. Body weight and the morphometric parameters correlated positively with leptin concentrations and negatively with total ghrelin concentrations. These results suggest that ghrelin and leptin could play a role in dogs in the adaptation to a positive or negative energy balance, as observed in humans. SN - 0034-5288 UR - https://www.unboundmedicine.com/medline/citation/15924935/Effects_of_chronic_obesity_and_weight_loss_on_plasma_ghrelin_and_leptin_concentrations_in_dogs_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0034-5288(04)00231-0 DB - PRIME DP - Unbound Medicine ER -