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Metabolic and vascular abnormalities in subjects at risk for type 2 diabetes: the early start of a dangerous situation.
Arch Med Res. 2005 May-Jun; 36(3):241-9.AM

Abstract

Various groups at risk for type 2 diabetes have been identified, including individuals with family history of type 2 diabetes, obesity, prior gestational diabetes, polycystic ovary syndrome, metabolic syndrome, hypertension, dyslipidemia and particularly those with pre-diabetes (impaired glucose tolerance and/or impaired fasting glucose). To various degrees, all these groups have also been identified with significant vascular abnormalities that range from endothelial dysfunction and low-grade or sub-clinical inflammation to evident atherosclerosis. The mechanisms involved in establishing a link between the risk of type 2 diabetes and vascular dysfunction are multiple and complex. The presence in the circulation of various cytokines, hormones and substrates associated with increased visceral fat and insulin resistance, the frequent appearance of associated cardiovascular risk factors and/or the possibility of some genetically determined intrinsic vascular abnormalities are all explanatory mechanisms that are being evaluated in clinical research. Whereas the possibility of appreciating a significant reduction in cardiovascular outcomes in long-term prospective clinical trials in all these groups at risk for type 2 diabetes is still lacking, understanding these mechanisms and recognizing how various interventions may improve vascular health is a worthwhile area of research that may translate into important clinical strategies to reduce the burden of type 2 diabetes and cardiovascular disease.

Authors+Show Affiliations

Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA. enrique.caballero@joslin.harvard.edu

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15925014

Citation

Caballero, A Enrique. "Metabolic and Vascular Abnormalities in Subjects at Risk for Type 2 Diabetes: the Early Start of a Dangerous Situation." Archives of Medical Research, vol. 36, no. 3, 2005, pp. 241-9.
Caballero AE. Metabolic and vascular abnormalities in subjects at risk for type 2 diabetes: the early start of a dangerous situation. Arch Med Res. 2005;36(3):241-9.
Caballero, A. E. (2005). Metabolic and vascular abnormalities in subjects at risk for type 2 diabetes: the early start of a dangerous situation. Archives of Medical Research, 36(3), 241-9.
Caballero AE. Metabolic and Vascular Abnormalities in Subjects at Risk for Type 2 Diabetes: the Early Start of a Dangerous Situation. Arch Med Res. 2005 May-Jun;36(3):241-9. PubMed PMID: 15925014.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metabolic and vascular abnormalities in subjects at risk for type 2 diabetes: the early start of a dangerous situation. A1 - Caballero,A Enrique, PY - 2004/12/20/received PY - 2004/12/20/accepted PY - 2005/6/1/pubmed PY - 2005/9/17/medline PY - 2005/6/1/entrez SP - 241 EP - 9 JF - Archives of medical research JO - Arch Med Res VL - 36 IS - 3 N2 - Various groups at risk for type 2 diabetes have been identified, including individuals with family history of type 2 diabetes, obesity, prior gestational diabetes, polycystic ovary syndrome, metabolic syndrome, hypertension, dyslipidemia and particularly those with pre-diabetes (impaired glucose tolerance and/or impaired fasting glucose). To various degrees, all these groups have also been identified with significant vascular abnormalities that range from endothelial dysfunction and low-grade or sub-clinical inflammation to evident atherosclerosis. The mechanisms involved in establishing a link between the risk of type 2 diabetes and vascular dysfunction are multiple and complex. The presence in the circulation of various cytokines, hormones and substrates associated with increased visceral fat and insulin resistance, the frequent appearance of associated cardiovascular risk factors and/or the possibility of some genetically determined intrinsic vascular abnormalities are all explanatory mechanisms that are being evaluated in clinical research. Whereas the possibility of appreciating a significant reduction in cardiovascular outcomes in long-term prospective clinical trials in all these groups at risk for type 2 diabetes is still lacking, understanding these mechanisms and recognizing how various interventions may improve vascular health is a worthwhile area of research that may translate into important clinical strategies to reduce the burden of type 2 diabetes and cardiovascular disease. SN - 0188-4409 UR - https://www.unboundmedicine.com/medline/citation/15925014/Metabolic_and_vascular_abnormalities_in_subjects_at_risk_for_type_2_diabetes:_the_early_start_of_a_dangerous_situation_ DB - PRIME DP - Unbound Medicine ER -