Tags

Type your tag names separated by a space and hit enter

Improving the solubility of ampelopsin by solid dispersions and inclusion complexes.
J Pharm Biomed Anal. 2005 Jul 01; 38(3):457-64.JP

Abstract

The aim of this study was to increase the solubility of ampelopsin (AMP) in water by two systems: solid dispersions with polyethylene glycol 6000 (PEG 6000) or polyvinylpyrrolidone K-30 (PVP K30) and inclusion complexes with beta-cyclodextrin (BCD) and hydroxypropyl-beta-cyclodextrin (HPBCD). The interaction of AMP with the hydrophilic polymers was evaluated by differential scanning calorimetry (DSC), Fourier transformation-infrared spectroscopy (FTIR), scanning electron microscopy (SEM). The results from DSC, FTIR and SEC analyses of solid dispersions and inclusion complexes showed that AMP might exist as an amorphous state or as a solid solution. On the other hand, the SEM images of the physical mixtures revealed that to some extent the drug was present in a crystalline form. The influence of various factors (pH, temperature, type of polymer, ration of the drug to polymer) on the solubility and dissolution rate of the drug were also evaluated. The solubility and dissolution rates of AMP were significantly increased by solid dispersions and cyclodextrin complexes as well as their physical mixtures. The improvement of solubility using polymers was in the following order: HPBCD approximately BCD>PVP K30>PEG 6000.

Authors+Show Affiliations

School of Chinese Pharmacy, China Pharmaceutical University, Nanjing, 210009, PR China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15925247

Citation

Ruan, Li-Ping, et al. "Improving the Solubility of Ampelopsin By Solid Dispersions and Inclusion Complexes." Journal of Pharmaceutical and Biomedical Analysis, vol. 38, no. 3, 2005, pp. 457-64.
Ruan LP, Yu BY, Fu GM, et al. Improving the solubility of ampelopsin by solid dispersions and inclusion complexes. J Pharm Biomed Anal. 2005;38(3):457-64.
Ruan, L. P., Yu, B. Y., Fu, G. M., & Zhu, D. N. (2005). Improving the solubility of ampelopsin by solid dispersions and inclusion complexes. Journal of Pharmaceutical and Biomedical Analysis, 38(3), 457-64.
Ruan LP, et al. Improving the Solubility of Ampelopsin By Solid Dispersions and Inclusion Complexes. J Pharm Biomed Anal. 2005 Jul 1;38(3):457-64. PubMed PMID: 15925247.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Improving the solubility of ampelopsin by solid dispersions and inclusion complexes. AU - Ruan,Li-Ping, AU - Yu,Bo-Yang, AU - Fu,Guang-Miao, AU - Zhu,Dan-Ni, Y1 - 2005/03/02/ PY - 2004/08/21/received PY - 2005/01/31/revised PY - 2005/01/31/accepted PY - 2005/6/1/pubmed PY - 2006/5/23/medline PY - 2005/6/1/entrez SP - 457 EP - 64 JF - Journal of pharmaceutical and biomedical analysis JO - J Pharm Biomed Anal VL - 38 IS - 3 N2 - The aim of this study was to increase the solubility of ampelopsin (AMP) in water by two systems: solid dispersions with polyethylene glycol 6000 (PEG 6000) or polyvinylpyrrolidone K-30 (PVP K30) and inclusion complexes with beta-cyclodextrin (BCD) and hydroxypropyl-beta-cyclodextrin (HPBCD). The interaction of AMP with the hydrophilic polymers was evaluated by differential scanning calorimetry (DSC), Fourier transformation-infrared spectroscopy (FTIR), scanning electron microscopy (SEM). The results from DSC, FTIR and SEC analyses of solid dispersions and inclusion complexes showed that AMP might exist as an amorphous state or as a solid solution. On the other hand, the SEM images of the physical mixtures revealed that to some extent the drug was present in a crystalline form. The influence of various factors (pH, temperature, type of polymer, ration of the drug to polymer) on the solubility and dissolution rate of the drug were also evaluated. The solubility and dissolution rates of AMP were significantly increased by solid dispersions and cyclodextrin complexes as well as their physical mixtures. The improvement of solubility using polymers was in the following order: HPBCD approximately BCD>PVP K30>PEG 6000. SN - 0731-7085 UR - https://www.unboundmedicine.com/medline/citation/15925247/Improving_the_solubility_of_ampelopsin_by_solid_dispersions_and_inclusion_complexes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0731-7085(05)00079-8 DB - PRIME DP - Unbound Medicine ER -