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Assay of the anti-psychotic drug haloperidol in bulk form, pharmaceutical formulation and biological fluids using square-wave adsorptive stripping voltammetry at a mercury electrode.
J Pharm Biomed Anal. 2005 Jul 01; 38(3):543-50.JP

Abstract

The cyclic voltammetric behavior of haloperidol at a hanging mercury drop electrode was studied in Britton-Robinson buffer series of pH 2.5-11 containing 40% (v/v) ethanol. A single two-electron irreversible cathodic peak was obtained which attributed to reduction of the CO double bond. In addition, a small enhanced adsorptive pre-wave was observed at less negative potentials over the pH range 3.5-11. Controlled adsorptive accumulation of haloperidol onto the hanging mercury drop electrode provided the basis for its direct trace assay in bulk form, pharmaceutical formulation and human biological fluids using square-wave adsorptive cathodic stripping voltammetry. Following preconcentration of bulk haloperidol onto the HMDE a well-developed square-wave cathodic peak was generated in Britton-Robinson buffer especially at pH values 9-10; its peak current showed a linear dependence on the concentration of haloperidol over the range 1 x 10(-9)M to 1.5 x 10(-6)M depending on the preconcentration duration. The procedural parameters for assay of haloperidol were studied. The achieved limits of detection (LOD) and quantitation (LOQ) were 3.83 x 10(-10)M and 1.28 x 10(-9)M bulk haloperidol, respectively. The procedure was successfully applied to assay haloperidol in tablets (Safinace) and in spiked human serum and urine. LOD of 3.3 x 10(-9)M and 5.46 x 10(-9)M, and LOQ of 1.10 x 10(-8) and 1.82 x 10(-8)M haloperidol were achieved in spiked human serum and urine samples, respectively.

Authors+Show Affiliations

Department of Chemistry, Faculty of Science, Tanta University, 31527 Tanta, Egypt. hseldesoky@hotmail.comNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15925258

Citation

El-Desoky, H S., and M M. Ghoneim. "Assay of the Anti-psychotic Drug Haloperidol in Bulk Form, Pharmaceutical Formulation and Biological Fluids Using Square-wave Adsorptive Stripping Voltammetry at a Mercury Electrode." Journal of Pharmaceutical and Biomedical Analysis, vol. 38, no. 3, 2005, pp. 543-50.
El-Desoky HS, Ghoneim MM. Assay of the anti-psychotic drug haloperidol in bulk form, pharmaceutical formulation and biological fluids using square-wave adsorptive stripping voltammetry at a mercury electrode. J Pharm Biomed Anal. 2005;38(3):543-50.
El-Desoky, H. S., & Ghoneim, M. M. (2005). Assay of the anti-psychotic drug haloperidol in bulk form, pharmaceutical formulation and biological fluids using square-wave adsorptive stripping voltammetry at a mercury electrode. Journal of Pharmaceutical and Biomedical Analysis, 38(3), 543-50.
El-Desoky HS, Ghoneim MM. Assay of the Anti-psychotic Drug Haloperidol in Bulk Form, Pharmaceutical Formulation and Biological Fluids Using Square-wave Adsorptive Stripping Voltammetry at a Mercury Electrode. J Pharm Biomed Anal. 2005 Jul 1;38(3):543-50. PubMed PMID: 15925258.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Assay of the anti-psychotic drug haloperidol in bulk form, pharmaceutical formulation and biological fluids using square-wave adsorptive stripping voltammetry at a mercury electrode. AU - El-Desoky,H S, AU - Ghoneim,M M, Y1 - 2005/02/26/ PY - 2004/04/21/received PY - 2005/01/17/revised PY - 2005/01/20/accepted PY - 2005/6/1/pubmed PY - 2006/5/23/medline PY - 2005/6/1/entrez SP - 543 EP - 50 JF - Journal of pharmaceutical and biomedical analysis JO - J Pharm Biomed Anal VL - 38 IS - 3 N2 - The cyclic voltammetric behavior of haloperidol at a hanging mercury drop electrode was studied in Britton-Robinson buffer series of pH 2.5-11 containing 40% (v/v) ethanol. A single two-electron irreversible cathodic peak was obtained which attributed to reduction of the CO double bond. In addition, a small enhanced adsorptive pre-wave was observed at less negative potentials over the pH range 3.5-11. Controlled adsorptive accumulation of haloperidol onto the hanging mercury drop electrode provided the basis for its direct trace assay in bulk form, pharmaceutical formulation and human biological fluids using square-wave adsorptive cathodic stripping voltammetry. Following preconcentration of bulk haloperidol onto the HMDE a well-developed square-wave cathodic peak was generated in Britton-Robinson buffer especially at pH values 9-10; its peak current showed a linear dependence on the concentration of haloperidol over the range 1 x 10(-9)M to 1.5 x 10(-6)M depending on the preconcentration duration. The procedural parameters for assay of haloperidol were studied. The achieved limits of detection (LOD) and quantitation (LOQ) were 3.83 x 10(-10)M and 1.28 x 10(-9)M bulk haloperidol, respectively. The procedure was successfully applied to assay haloperidol in tablets (Safinace) and in spiked human serum and urine. LOD of 3.3 x 10(-9)M and 5.46 x 10(-9)M, and LOQ of 1.10 x 10(-8) and 1.82 x 10(-8)M haloperidol were achieved in spiked human serum and urine samples, respectively. SN - 0731-7085 UR - https://www.unboundmedicine.com/medline/citation/15925258/Assay_of_the_anti_psychotic_drug_haloperidol_in_bulk_form_pharmaceutical_formulation_and_biological_fluids_using_square_wave_adsorptive_stripping_voltammetry_at_a_mercury_electrode_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0731-7085(05)00046-4 DB - PRIME DP - Unbound Medicine ER -