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Influence of preoperative administration of omega-3 fatty acid-enriched supplement on inflammatory and immune responses in patients undergoing major surgery for cancer.
Nutrition. 2005 Jun; 21(6):639-49.N

Abstract

OBJECTIVE

Polyunsaturated fatty acid supplementation may produce beneficial effects after surgery. We investigated the influence of preoperative administration of a supplement rich in arginine, omega-3 fatty acids, and RNA, Impact (Japan), on inflammatory and immune responses in patients undergoing major surgery for cancer.

METHODS

Patients in the supplement group (n = 12) received 1 L/d of Impact (Japan) for 5 d before surgery, and those in the control group (n = 14) received an ordinary diet without Impact (Japan) before surgery. Plasma levels of omega-3 and omega-6 fatty acids, thromboxane B(2), prostaglandin E(2), inflammatory markers, nutritional markers, cytokines, and cytokine receptors were obtained 5 d before the operation at the starting point of supplementation in the supplement group. Samples were collected on postoperative days (PODs) 0, 1, 3, and 7.

RESULTS

After taking the supplement, significant increases in omega-3 fatty acids and rapid turnover proteins were found the day after ending supplementation (POD-0), whereas thromboxane B(2) levels and the ratio of omega-6 fatty acids to omega-3 fatty acids were significantly lower than before supplementation (P < 0.001). On POD-0 only, inflammatory markers and cytokine receptors in the supplement group showed low levels in comparison with the control group (P < 0.05). On POD-1 and POD-3, remarkable decreases in polymorphonuclear leukocyte-elastase and interleukin-8 in the supplement group were observed.

CONCLUSION

Our findings suggest that oral administration of a supplement rich in omega-3 fatty acids for 5 d before surgery may improve not only preoperative nutritional status but also preoperative and postoperative inflammatory and immune responses in patients who have cancer.

Authors+Show Affiliations

Department of Clinical Pharmacy and Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, Japan. nakamura@m3.kufm.kagoshima-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

15925286

Citation

Nakamura, Kazuo, et al. "Influence of Preoperative Administration of Omega-3 Fatty Acid-enriched Supplement On Inflammatory and Immune Responses in Patients Undergoing Major Surgery for Cancer." Nutrition (Burbank, Los Angeles County, Calif.), vol. 21, no. 6, 2005, pp. 639-49.
Nakamura K, Kariyazono H, Komokata T, et al. Influence of preoperative administration of omega-3 fatty acid-enriched supplement on inflammatory and immune responses in patients undergoing major surgery for cancer. Nutrition. 2005;21(6):639-49.
Nakamura, K., Kariyazono, H., Komokata, T., Hamada, N., Sakata, R., & Yamada, K. (2005). Influence of preoperative administration of omega-3 fatty acid-enriched supplement on inflammatory and immune responses in patients undergoing major surgery for cancer. Nutrition (Burbank, Los Angeles County, Calif.), 21(6), 639-49.
Nakamura K, et al. Influence of Preoperative Administration of Omega-3 Fatty Acid-enriched Supplement On Inflammatory and Immune Responses in Patients Undergoing Major Surgery for Cancer. Nutrition. 2005;21(6):639-49. PubMed PMID: 15925286.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of preoperative administration of omega-3 fatty acid-enriched supplement on inflammatory and immune responses in patients undergoing major surgery for cancer. AU - Nakamura,Kazuo, AU - Kariyazono,Hiroko, AU - Komokata,Teruo, AU - Hamada,Nobuo, AU - Sakata,Ryuzo, AU - Yamada,Katsushi, PY - 2004/11/27/received PY - 2005/02/15/accepted PY - 2005/6/1/pubmed PY - 2005/10/18/medline PY - 2005/6/1/entrez SP - 639 EP - 49 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 21 IS - 6 N2 - OBJECTIVE: Polyunsaturated fatty acid supplementation may produce beneficial effects after surgery. We investigated the influence of preoperative administration of a supplement rich in arginine, omega-3 fatty acids, and RNA, Impact (Japan), on inflammatory and immune responses in patients undergoing major surgery for cancer. METHODS: Patients in the supplement group (n = 12) received 1 L/d of Impact (Japan) for 5 d before surgery, and those in the control group (n = 14) received an ordinary diet without Impact (Japan) before surgery. Plasma levels of omega-3 and omega-6 fatty acids, thromboxane B(2), prostaglandin E(2), inflammatory markers, nutritional markers, cytokines, and cytokine receptors were obtained 5 d before the operation at the starting point of supplementation in the supplement group. Samples were collected on postoperative days (PODs) 0, 1, 3, and 7. RESULTS: After taking the supplement, significant increases in omega-3 fatty acids and rapid turnover proteins were found the day after ending supplementation (POD-0), whereas thromboxane B(2) levels and the ratio of omega-6 fatty acids to omega-3 fatty acids were significantly lower than before supplementation (P < 0.001). On POD-0 only, inflammatory markers and cytokine receptors in the supplement group showed low levels in comparison with the control group (P < 0.05). On POD-1 and POD-3, remarkable decreases in polymorphonuclear leukocyte-elastase and interleukin-8 in the supplement group were observed. CONCLUSION: Our findings suggest that oral administration of a supplement rich in omega-3 fatty acids for 5 d before surgery may improve not only preoperative nutritional status but also preoperative and postoperative inflammatory and immune responses in patients who have cancer. SN - 0899-9007 UR - https://www.unboundmedicine.com/medline/citation/15925286/Influence_of_preoperative_administration_of_omega_3_fatty_acid_enriched_supplement_on_inflammatory_and_immune_responses_in_patients_undergoing_major_surgery_for_cancer_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(05)00102-4 DB - PRIME DP - Unbound Medicine ER -