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Radiation therapy for orbital lymphoma.
Int J Radiat Oncol Biol Phys. 2005 Nov 01; 63(3):866-71.IJ

Abstract

PURPOSE

To describe radiation techniques and evaluate outcomes for orbital lymphoma.

METHODS AND MATERIALS

Forty-six patients (and 62 eyes) with orbital lymphoma treated with radiotherapy between 1987 and 2003 were included. The majority had mucosa-associated lymphoid tissue (48%) or follicular (30%) lymphoma. Seventeen patients had prior lymphoma at other sites, and 29 had primary orbital lymphoma. Median follow-up was 46 months.

RESULTS

The median dose was 30.6 Gy; one-third received <30 Gy. Electrons were used in 9 eyes with disease confined to the conjunctiva or eyelid, and photons in 53 eyes with involvement of intraorbital tissues to cover entire orbit. Local control rate was 98% for all patients and 100% for those with indolent lymphoma. Three of the 26 patients with localized primary lymphoma failed distantly, resulting in a 5-year freedom-from-distant-relapse rate of 89%. The 5-year disease-specific and overall survival rates were 95% and 88%, respectively. Late toxicity was mainly cataract formation in patients who received radiation without lens block.

CONCLUSIONS

A dose of 30 Gy is sufficient for indolent orbital lymphoma. Distant relapse rate in patients with localized orbital lymphoma was lower than that reported for low-grade lymphoma presenting in other sites. Orbital radiotherapy can be used for salvage of recurrent indolent lymphoma.

Authors+Show Affiliations

Department of Radiation Oncology, Brigham and Women's Hospital and Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA. pzhou@partners.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15925453

Citation

Zhou, Ping, et al. "Radiation Therapy for Orbital Lymphoma." International Journal of Radiation Oncology, Biology, Physics, vol. 63, no. 3, 2005, pp. 866-71.
Zhou P, Ng AK, Silver B, et al. Radiation therapy for orbital lymphoma. Int J Radiat Oncol Biol Phys. 2005;63(3):866-71.
Zhou, P., Ng, A. K., Silver, B., Li, S., Hua, L., & Mauch, P. M. (2005). Radiation therapy for orbital lymphoma. International Journal of Radiation Oncology, Biology, Physics, 63(3), 866-71.
Zhou P, et al. Radiation Therapy for Orbital Lymphoma. Int J Radiat Oncol Biol Phys. 2005 Nov 1;63(3):866-71. PubMed PMID: 15925453.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Radiation therapy for orbital lymphoma. AU - Zhou,Ping, AU - Ng,Andrea K, AU - Silver,Barbara, AU - Li,Sigui, AU - Hua,Ling, AU - Mauch,Peter M, Y1 - 2005/05/31/ PY - 2005/01/28/received PY - 2005/03/08/revised PY - 2005/03/09/accepted PY - 2005/6/1/pubmed PY - 2005/12/13/medline PY - 2005/6/1/entrez SP - 866 EP - 71 JF - International journal of radiation oncology, biology, physics JO - Int. J. Radiat. Oncol. Biol. Phys. VL - 63 IS - 3 N2 - PURPOSE: To describe radiation techniques and evaluate outcomes for orbital lymphoma. METHODS AND MATERIALS: Forty-six patients (and 62 eyes) with orbital lymphoma treated with radiotherapy between 1987 and 2003 were included. The majority had mucosa-associated lymphoid tissue (48%) or follicular (30%) lymphoma. Seventeen patients had prior lymphoma at other sites, and 29 had primary orbital lymphoma. Median follow-up was 46 months. RESULTS: The median dose was 30.6 Gy; one-third received <30 Gy. Electrons were used in 9 eyes with disease confined to the conjunctiva or eyelid, and photons in 53 eyes with involvement of intraorbital tissues to cover entire orbit. Local control rate was 98% for all patients and 100% for those with indolent lymphoma. Three of the 26 patients with localized primary lymphoma failed distantly, resulting in a 5-year freedom-from-distant-relapse rate of 89%. The 5-year disease-specific and overall survival rates were 95% and 88%, respectively. Late toxicity was mainly cataract formation in patients who received radiation without lens block. CONCLUSIONS: A dose of 30 Gy is sufficient for indolent orbital lymphoma. Distant relapse rate in patients with localized orbital lymphoma was lower than that reported for low-grade lymphoma presenting in other sites. Orbital radiotherapy can be used for salvage of recurrent indolent lymphoma. SN - 0360-3016 UR - https://www.unboundmedicine.com/medline/citation/15925453/Radiation_therapy_for_orbital_lymphoma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0360-3016(05)00417-7 DB - PRIME DP - Unbound Medicine ER -