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Non-hematopoietic bone marrow stem cells: molecular control of expansion and differentiation.
Exp Cell Res. 2005 Jun 10; 306(2):330-5.EC

Abstract

The first non-hematopoietic mesenchymal stem cells (MSCs) were discovered by Friedenstein in 1976, who described clonal, plastic adherent cells from bone marrow capable of differentiating into osteoblasts, adipocytes, and chondrocytes. More recently, investigators have now demonstrated that multi-potent MSCs can be recovered from a variety of other adult tissues and differentiate into numerous tissue lineages including myoblasts, hepatocytes and possibly even neural tissue. Because MSCs are multipotent and easily expanded in culture, there has been much interest in their clinical potential for tissue repair and gene therapy and as a result, numerous studies have been carried out demonstrating the migration and multi-organ engraftment potential of MSCs in animal models and in human clinical trials. This review describes the recent advances in the understanding of MSC biology.

Authors+Show Affiliations

Center for Gene Therapy, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA. cgregory@tulane.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15925588

Citation

Gregory, Carl A., et al. "Non-hematopoietic Bone Marrow Stem Cells: Molecular Control of Expansion and Differentiation." Experimental Cell Research, vol. 306, no. 2, 2005, pp. 330-5.
Gregory CA, Prockop DJ, Spees JL. Non-hematopoietic bone marrow stem cells: molecular control of expansion and differentiation. Exp Cell Res. 2005;306(2):330-5.
Gregory, C. A., Prockop, D. J., & Spees, J. L. (2005). Non-hematopoietic bone marrow stem cells: molecular control of expansion and differentiation. Experimental Cell Research, 306(2), 330-5.
Gregory CA, Prockop DJ, Spees JL. Non-hematopoietic Bone Marrow Stem Cells: Molecular Control of Expansion and Differentiation. Exp Cell Res. 2005 Jun 10;306(2):330-5. PubMed PMID: 15925588.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Non-hematopoietic bone marrow stem cells: molecular control of expansion and differentiation. AU - Gregory,Carl A, AU - Prockop,Darwin J, AU - Spees,Jeffrey L, Y1 - 2005/04/15/ PY - 2005/03/03/received PY - 2005/03/03/revised PY - 2005/03/14/accepted PY - 2005/6/1/pubmed PY - 2005/7/27/medline PY - 2005/6/1/entrez SP - 330 EP - 5 JF - Experimental cell research JO - Exp. Cell Res. VL - 306 IS - 2 N2 - The first non-hematopoietic mesenchymal stem cells (MSCs) were discovered by Friedenstein in 1976, who described clonal, plastic adherent cells from bone marrow capable of differentiating into osteoblasts, adipocytes, and chondrocytes. More recently, investigators have now demonstrated that multi-potent MSCs can be recovered from a variety of other adult tissues and differentiate into numerous tissue lineages including myoblasts, hepatocytes and possibly even neural tissue. Because MSCs are multipotent and easily expanded in culture, there has been much interest in their clinical potential for tissue repair and gene therapy and as a result, numerous studies have been carried out demonstrating the migration and multi-organ engraftment potential of MSCs in animal models and in human clinical trials. This review describes the recent advances in the understanding of MSC biology. SN - 0014-4827 UR - https://www.unboundmedicine.com/medline/citation/15925588/Non_hematopoietic_bone_marrow_stem_cells:_molecular_control_of_expansion_and_differentiation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-4827(05)00139-4 DB - PRIME DP - Unbound Medicine ER -