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CC chemokine receptor 4 ligand production by bronchoalveolar lavage fluid cells in cigarette-smoke-associated acute eosinophilic pneumonia.
Clin Immunol. 2005 Jul; 116(1):83-93.CI

Abstract

We examined the production of macrophage-derived chemokine (MDC/CCL22) and thymus- and activation-regulated chemokine (TARC/CCL17) by bronchoalveolar lavage fluid (BALF) cells in cigarette-smoke-associated acute eosinophilic pneumonia (CS-AEP). The CC Chemokine Receptor 4 (CCR4) ligand levels in BALF from patients with CS-AEP were considerably higher than those in healthy volunteers and correlated well with Th2 cytokine levels. Interleukin-4 enhanced CCR4 ligand production. MDC expression was observed in CD68-positive cells from patients with CS-AEP and in healthy control smokers. In contrast, TARC expression in CD68- or CD1a-positive cells was detected only in CS-AEP. An in vivo cigarette smoke challenge test induced increases in CCR4 ligands in the BALF and in the cultured supernatant of BALF adherent cells. These results suggest that alveolar macrophages and dendritic cells contribute to the pathogenesis of CS-AEP by generating CCR4 ligands, probably in response to cigarette smoke.

Authors+Show Affiliations

Division of Pulmonary Disease, Third Department of Internal Medicine, Oita University Faculty of Medicine, 1-1 Idaigaoka, Hasama-machi, Oita 879-5593, Japan. nureki@med.oita-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15925835

Citation

Nureki, Shin-ichi, et al. "CC Chemokine Receptor 4 Ligand Production By Bronchoalveolar Lavage Fluid Cells in Cigarette-smoke-associated Acute Eosinophilic Pneumonia." Clinical Immunology (Orlando, Fla.), vol. 116, no. 1, 2005, pp. 83-93.
Nureki S, Miyazaki E, Ando M, et al. CC chemokine receptor 4 ligand production by bronchoalveolar lavage fluid cells in cigarette-smoke-associated acute eosinophilic pneumonia. Clin Immunol. 2005;116(1):83-93.
Nureki, S., Miyazaki, E., Ando, M., Kumamoto, T., & Tsuda, T. (2005). CC chemokine receptor 4 ligand production by bronchoalveolar lavage fluid cells in cigarette-smoke-associated acute eosinophilic pneumonia. Clinical Immunology (Orlando, Fla.), 116(1), 83-93.
Nureki S, et al. CC Chemokine Receptor 4 Ligand Production By Bronchoalveolar Lavage Fluid Cells in Cigarette-smoke-associated Acute Eosinophilic Pneumonia. Clin Immunol. 2005;116(1):83-93. PubMed PMID: 15925835.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CC chemokine receptor 4 ligand production by bronchoalveolar lavage fluid cells in cigarette-smoke-associated acute eosinophilic pneumonia. AU - Nureki,Shin-ichi, AU - Miyazaki,Eishi, AU - Ando,Masaru, AU - Kumamoto,Toshihide, AU - Tsuda,Tomiyasu, PY - 2004/07/13/received PY - 2005/03/01/revised PY - 2005/03/02/accepted PY - 2005/6/1/pubmed PY - 2005/8/10/medline PY - 2005/6/1/entrez SP - 83 EP - 93 JF - Clinical immunology (Orlando, Fla.) JO - Clin Immunol VL - 116 IS - 1 N2 - We examined the production of macrophage-derived chemokine (MDC/CCL22) and thymus- and activation-regulated chemokine (TARC/CCL17) by bronchoalveolar lavage fluid (BALF) cells in cigarette-smoke-associated acute eosinophilic pneumonia (CS-AEP). The CC Chemokine Receptor 4 (CCR4) ligand levels in BALF from patients with CS-AEP were considerably higher than those in healthy volunteers and correlated well with Th2 cytokine levels. Interleukin-4 enhanced CCR4 ligand production. MDC expression was observed in CD68-positive cells from patients with CS-AEP and in healthy control smokers. In contrast, TARC expression in CD68- or CD1a-positive cells was detected only in CS-AEP. An in vivo cigarette smoke challenge test induced increases in CCR4 ligands in the BALF and in the cultured supernatant of BALF adherent cells. These results suggest that alveolar macrophages and dendritic cells contribute to the pathogenesis of CS-AEP by generating CCR4 ligands, probably in response to cigarette smoke. SN - 1521-6616 UR - https://www.unboundmedicine.com/medline/citation/15925835/CC_chemokine_receptor_4_ligand_production_by_bronchoalveolar_lavage_fluid_cells_in_cigarette_smoke_associated_acute_eosinophilic_pneumonia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1521-6616(05)00068-9 DB - PRIME DP - Unbound Medicine ER -